DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and PDZK1

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_024303384.1	Gene:	PDZK1 / 5174	HGNCID:	8821	Length:	539	Species:	Homo sapiens

Alignment Length:	306	Identity:	76/306 - (24%)
Similarity:	131/306 - (42%)	Gaps:	75/306 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 RTVEVRRGYNGFGFTI---SGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQ 131
            |.||:::|.||:||.:   |.|:...:..|.|.||||:|||::.|.:::|||.:|..|.|::||:
Human   262 RIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVE 326

  Fly   132 LIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLN 196
            :|........:.:.:      .:.:|.:          .|.|...||:::::  .|.|...|:..
Human   327 MIRKGGDQTSLLVVD------KETDNMY----------RLAHFSPFLYYQSQ--ELPNGSVKEAP 373

  Fly   197 PP-----EAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAAD--VANVSAMVRAVGS-------- 246
            .|     |...|..:....||   ||.|      ..|:|..:  ..:::|:....||
Human   374 APTPTSLEVSSPPDTTEEVDH---KPKL------CRLAKGENGYGFHLNAIRGLPGSFIKEVQKG 429

  Fly   247 -----AALECR---VIVGYLGTIEMP-----KQISHSSKLQTVRSCIRKLR---QEKRQPTIVLM 295
                 |.||..   :.|..:..::.|     .:|..|.|..|:..|.:|..   |.|:.|.:..:
Human   430 GPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSL 494

  Fly   296 C----ITPDS---LSLQSSSGGVLA---TYSSARLNFVSSSSESEN 331
            .    ..|||   :.::|:....:|   .:|:|.    .|||.||:
Human   495 ADPLDTPPDSKEGIVVESNHDSHMAKERAHSTAS----HSSSNSED 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	29/77 (38%)
		PTB_RGS12	251..391	CDD:269984	23/102 (23%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
PDZK1	XP_024303384.1	PDZ_signaling	27..107	CDD:238492
		PDZ	152..232	CDD:214570
		PDZ_signaling	261..340	CDD:238492	29/77 (38%)
		PDZ	395..475	CDD:214570	17/85 (20%)
		F1-ATPase_gamma	<457..>501	CDD:320933	9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900