DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and PDZD11

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_016885057.1	Gene:	PDZD11 / 51248	HGNCID:	28034	Length:	172	Species:	Homo sapiens

Alignment Length:	142	Identity:	36/142 - (25%)
Similarity:	62/142 - (43%)	Gaps:	30/142 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGI-----RTVEVRRGYNG-FGFTISGQQ 89
            ||..:.||.|           ..|:  |....:|| |.:     ||:.:::.... .||.|.|.:
Human    48 PAYENPPAWI-----------PPHE--RVHHPDYN-NELTQFLPRTITLKKPPGAQLGFNIRGGK 98

  Fly    90 PCRL----SCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQI---AEN 147
            ..:|    |.:|..|.|.:|||:.||.:::||.::...:.|...|::: .:...|.|::   ..|
Human    99 ASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEIL-KTAREISMRVRFFPYN 162

  Fly   148 YYSDSSDEENAH 159
            |:...  |...|
Human   163 YHRQK--ERTVH 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	22/88 (25%)
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
PDZD11	XP_016885057.1	PDZ_signaling	77..157	CDD:238492	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900