Protein Alignment loco and Rgs3

DIOPT Version :9

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_006538120.1
• Gene: Rgs3 / 50780
• MGIID: 1354734
• Length: 1143
• Species: Mus musculus
• Alignment Length: 1095
• Identity: 233/1095 - (21%)
• Similarity: 359/1095 - (32%)
• Gaps: 361/1095 - (32%)

  Fly    72 VEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVS-----KLPHE---- 127
            :.:|||.:||||||....|.|:..:.|..|||:|||:..|.::.:|...|.     :|.||
Mouse   196 ITIRRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSC 260

  Fly   128 --TVVQLI---------GNSFGSIRMQIAENYYS------------------------------D 151
              .::.|:         |...|.:|....::.:.                              |
Mouse   261 PSEIILLVWRVVPQIKPGPDGGVLRRASCKSTHDLLSPPNKREKNCTHGAPVRPEQRHSCHLVCD 325

  Fly   152 SSDEENAHATLRGQLLAASLRH----KPRFLHHKAKLHRLRNSPQKK------LNP--------- 197
            |||         |.||....|:    |....|....|.|........      |||
Mouse   326 SSD---------GLLLGGWERYTEVGKRSGQHTLPALSRTTTPTDPNYIILAPLNPGSQLLRPVY 381

  Fly   198 -----PE-------------------------------------AVEPHKSKSS-PDHPTLKPV- 218
                 ||                                     |:.||...|| ..:.||.|.
Mouse   382 QEDTIPEEPGTTTKGKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKV 446

  Fly   219 -----------LEDPPLTANLSKAA---DVANVSAMVRAVGSAAL----------ECRVIVG--Y 257
                       |.:|..|..||:..   :..|.::.|.....:.|          .|.|:..  |
Mouse   447 LVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLY 511

  Fly   258 LGTIEMPKQISHSSK-----LQTVRSCIRKL-----RQEKRQPTIVLMCITPDSLSLQSSSGGVL 312
            |.::::.:..|...|     |.....|:..|     .|:||    |..|::.:....|.     |
Mouse   512 LQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKR----VCWCLSENIAKQQQ-----L 567

  Fly   313 ATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTK 377
            |...:.|..|.:.:.|.|             ..:.|...|.|...|.:.:.|
Mouse   568 AAPPTERKMFETEADEKE-------------MPLVEGKGPGAEEPAPSKNPS------------- 606

  Fly   378 LIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGA 442
               ..|.|....:  |..::||..:  .|.|...:              ||| |:......|
Mouse   607 ---PGQELPPGQD--LPPSKDPSPS--QELPAGQD--------------LPP-SKDPSPSQE--- 646

  Fly   443 GAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHA 507
              ..||..:..:..|.||....:...........|                 ..|..|..:.:..
Mouse   647 --LPAGQDLPPSKDPSPSQELPVGQDLPPRKDSSG-----------------QEAAPGPESPSSE 692

  Fly   508 GPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTS- 571
            ...|.|.|.:                .|:.|....|||...|              ||.|.|.|
Mouse   693 DIATCPKPPQ----------------SPETSTSKDSPPGQGS--------------SPTTELPSC 727

  Fly   572 --------TRSCDDVLN----------------LFVDDSPRTLAAVASMD--DISLHSAAPSLDE 610
                    :.|.|.:|:                |...:||.:|.::...|  :.::.|..|.:..
Mouse   728 QGLPAGQESTSQDPLLSQEPPVIPESSASVQKRLPSQESPSSLGSLPEKDLAEQTISSGEPPVAT 792

  Fly   611 GHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMD 675
            |...  ||..|..:...:.|:      ...:|:.|..|.  |.| |..|:.:....|...:...|
Mouse   793 GAVL--PASRPNFVIPEVRLD------NAYSQLDGAHGG--SSG-EDEDAEEGEEGGEGEEDEED 846

  Fly   676 TWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSF----RTP 736
            ..:.     .::.||:....||    |:|......  |..:|....|..||...:.|.    |.|
Mouse   847 DTSD-----DNYGDRSEAKRSS----LIETGQGAE--GGFSLRVQNSLRRRTHSEGSLLQESRGP 900

  Fly   737 --RSDKVAKEQQQLGQSS----PVRRTASMNASDN--DMYIKTL-------MLDSDL----KSSR 782
              .||.........|.:|    |..||.......|  .|:..:|       |..:||    ::||
Mouse   901 CFASDTTLHCSDGEGATSTWAIPSPRTLKKELGRNGGSMHHLSLFFTGHRKMSGTDLTECDEASR 965

  Fly   783 SQHQLSLLQVPKVL---------TTPAPPSAITASV------AAEGAAQDHGCPSSWAGSFERML 832
            .:...::.:..|..         :..|.|::.|...      .:|.|.:       |:.|.|::|
Mouse   966 KRKSKNIAKDMKNKLAIFRRRNESPGAQPASKTDKTTKSFKPTSEEALK-------WSESLEKLL 1023

  Fly   833 QDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQ 897
            ....|::.|..||:.|||.||:.||.|||.::.::|::...|:|::|||:.:|..:...||:||.
Mouse  1024 LHKYGLEVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSY 1088

  Fly   898 ARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPL 952
            .|..|:|.|.......|..|||:||.||:.|||.||:|||||...:..::.:.||
Mouse  1089 TREHTKENLQSITRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	28/92 (30%)
		PTB_RGS12	251..391	CDD:269984	28/151 (19%)
		RGS_R12-like	828..941	CDD:188661	49/112 (44%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Rgs3	XP_006538120.1	C2_RGS-like	35..154	CDD:176067
		PDZ_signaling	195..268	CDD:238492	24/71 (34%)
		PHA03307	578..>801	CDD:223039	54/324 (17%)
		RGS_RGS3	1019..1132	CDD:188668	49/112 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810