DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Patj

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	1030	Identity:	189/1030 - (18%)
Similarity:	331/1030 - (32%)	Gaps:	303/1030 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 PATNLTSTRSCDDVLNLFVDDSPRTLAAVA-SMDDISLHSAAPSLDEGHTFAHPACVPR----KM 624
            |...:.:..|...:|.:..|...||:..|. |:.:::...|          .||:.:|.    .:
  Fly    27 PKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLA----------QHPSMLPNDFDIDV 81

  Fly   625 RRSLAL------------ETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTW 677
            ..:|.|            |..::.|..||.  |.|.....:|.|.....|:|......|.....:
  Fly    82 AGNLVLSLNGGEVMYDFDEQRSSSHSHSAP--GSPDKSGGVGEEPRPQSQNSKGAGVADLYATDY 144

  Fly   678 ASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVA 742
            |.:|                    .:|..|....||...:.|..|..       ..:|.....||
  Fly   145 AQIQ--------------------AIELVNDGTGLGFGIIGARNSGV-------IVKTILPGGVA 182

  Fly   743 KEQQQLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQ---HQLSLLQVPKVLTTPAPPSA 804
            .:..:|.....:.:...:|..:        |:...:.:...|   |...::..|...:.|.|..|
  Fly   183 DKDGRLRSGDHILQIGDVNLHE--------MVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYA 239

  Fly   805 ITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQT------FSEFLKKEFSAENIYFWTACER- 862
            :....|.        .|:       |:|.|.|.::.      :.|...:..:|......|..:|
  Fly   240 LEPGTAV--------VPT-------RVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRF 289

  Fly   863 -YR------------------LLESE-----------------ADRVAQARE---IFAKHLANNS 888
             ||                  |.|:|                 |..|.:..|   ||.|.::..|
  Fly   290 VYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKEELSGIFVKSVSPGS 354

  Fly   889 SDPVNVDSQARSLTEEKLADA-APDIFAPAQKQIFSLMKFDS------YQRFIRSDLYKSCVEAE 946
            :    .|...|....:::.:. ...:...:..|...|:|...      .:|::|...::...:|.
  Fly   355 A----ADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAI 415

  Fly   947 QKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSK--SRDRTEIMA 1009
            ..|..||                          |:|.....::.:|....|.|.  :.....|..
  Fly   416 AANDKLP--------------------------SSAPGTPSRAPMPTPVATTSSATTTPSRSITR 454

  Fly  1010 DMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLC 1074
            :::...:|||......|.:..::              :.::||||.||...   .|..:|:
  Fly   455 ELEEEALPAPEAFMTTPPSVTTM--------------TTTTLSSFGAGKQL---VAVRDSL---- 498

  Fly  1075 RVILTDGATTIVQTRPGETVGELVERLLEKRNLV---YPYYDIVFQGSTKSIDVQQPSQILAGK- 1135
                 ||:|.|:.|.    |..|.::...|.:.|   :.||...........::.:..|.:.|.
  Fly   499 -----DGSTKIIPTE----VVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSD 554

  Fly  1136 -EVVIERRVAFK---LDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDL 1196
             ||::.:...|.   |.:.....:.|:...:.:.|..||.||                ...|:.:
  Fly   555 VEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSIL----------------PDGPVGV 603

  Fly  1197 NQPVTMAD------GQR------LRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVF 1249
            |..:...|      |:|      |.:|.:..:..:.........::..:.|.....|.:|:|. |
  Fly   604 NGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNN-F 667

  Fly  1250 NELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNI--PASKLPKLKKKST 1312
            ..||      .|:::     |...||:.:.:...|:        .||.::  .|:...|||.:|.
  Fly   668 ENLL------PATDR-----LVKAKSDGSLATAGSV--------ADGDSVAAAAASFSKLKSRSL 713

  Fly  1313 SSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDEL--------LEGLKRAQLARL 1369
                   |..|..|:...:..||..:|....|..:  :.::||.|        :..|....:|:|
  Fly   714 -------EPLTGLAMWSSQPQIIELVKGDRGLGFS--ILDYQDPLDPNDTLIVIRSLVPGGVAQL 769

  Fly  1370 EDQRGTEINFDLPDFLK--NKEN--LSAAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRS 1430
            :   |..|..|...|:.  |.||  |..||..|:  .||...|....|.|  :|.....|....:
  Fly   770 D---GRLIPGDRLLFVNSINLENASLDQAVQALK--GASKGVVRIGVAKP--LPMTDNSLKACSN 827

  Fly  1431 QQPVSPMKVDQEPETD-LPAATQDQTEFAKAPPPLPP------KPKVLPIKPSNW 1478
            ....|...:|.:|... ||..         |||.:||      :|.::|    :|
  Fly   828 ASTTSEETLDAQPSPPALPTV---------APPAMPPSASMGAEPDLIP----DW 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	27/165 (16%)
		RGS12_RBD	1073..1145	CDD:176412	15/76 (20%)
		RBD	1144..1213	CDD:128731	15/83 (18%)
Patj	NP_477342.1	L27	12..70	CDD:295425	9/52 (17%)
		PDZ_signaling	154..226	CDD:238492	13/86 (15%)
		PDZ_signaling	318..400	CDD:238492	12/85 (14%)
		PDZ_signaling	557..643	CDD:238492	16/101 (16%)
		PDZ_signaling	726..807	CDD:238492	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810