DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and a

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster

Alignment Length:	1526	Identity:	294/1526 - (19%)
Similarity:	488/1526 - (31%)	Gaps:	474/1526 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LLAASLRHKPRFLHHKAK---LHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLK---PVLEDPPL 224
            |.|...:.:.:...|:|:   :....||...|.:.|.......:||.....::.   |.|.|...
  Fly    16 LAAQQQQQQQQQQQHQAEGSNISHSSNSSSNKSHTPATCSNRLNKSIVSSTSISSSLPDLHDKSP 80

  Fly   225 TANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQ--ISHSSKLQTVR----SCIRKL 283
            ...||.....:|.:....||.:.|.......|  |:::..:|  :.|..:.|.:|    :|:...
  Fly    81 VMILSCTTLASNGATATAAVTATATGTAATSG--GSLQQQQQQHLQHQQQQQPLRTATPTCLLSG 143

  Fly   284 RQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEE 348
            ||            ||.::|                   |.|..|:         :::|..| ::
  Fly   144 RQ------------TPSAIS-------------------VMSLQEA---------TSLHRQQ-QQ 167

  Fly   349 EYEP---------------SAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRD 398
            .::|               :.|:::|.  :.:|:.      .|..|.:.|..|:.|..:.|
  Fly   168 PHQPPTIYVPVPTKLGNNVNTGNSSAT--LLLSYG------STSSIANLQQQQQQHAAQYQ---- 220

  Fly   399 PISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQAD----YEAGAGAAAAGGAVAAAHSPQP 459
                         :||               |.|.|.|.    ||.|:.  |:|||        .
  Fly   221 -------------QYV---------------AQRLHAASSSCLYEKGSN--ASGGA--------S 247

  Fly   460 SNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGI 524
            ||.|.:|.|.:..                                                   :
  Fly   248 SNKSSLSLTPNGH---------------------------------------------------L 261

  Fly   525 PDNRLTVRAMP------DHSALLRSPPASSSLRRPNLLASFN---------LIQSPATNLTSTRS 574
            ||.:| |.|||      :|.:  .|.||:.:.|..|..::.|         :..|.:.:.:||..
  Fly   262 PDYKL-VTAMPVVVLDDEHKS--NSLPATEASRNSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSL 323

  Fly   575 CDDVLNLFV--------------DDSPRTLAAVASMDDI-SL------HSAAPSLDEGHTFAHPA 618
            .....|:|.              .|||  .||..|..|: ||      |.:......|.:.|..:
  Fly   324 ASTTRNVFTWGKRMSRKLDLLKRSDSP--AAAHKSHSDLRSLFHSPTHHKSGSGGSSGPSSAKAS 386

  Fly   619 CVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNL 683
            ..|....::.:..|.:|..|..:........||....:...|||...:|
  Fly   387 ASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQDVGTG---------------- 435

  Fly   684 HKSHKDRTSMSASSS-SHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQ 747
                   .|.||.|: :|....|...:..|.|         |....|.:.....||..:.|..:.
  Fly   436 -------QSQSAQSTPTHQFQAAARPQKALKN---------FFHRIGSTGMLNHRSHNLLKASEA 484

  Fly   748 LGQSSP----VRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAP-----PS 803
            ..|::|    :.|::|.:...:..|:|.......|...|.|.:..|.::..:.::...     .|
  Fly   485 AQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKVSS 549

  Fly   804 AITASVAAEGAAQDHGCPSSWA-----GSFERMLQDAAGMQTFS-EFLKKEFSAENIYFWTACER 862
            .:|||.::..||...|.|.|.|     |:......|.:....|. .||:...|
  Fly   550 CLTASTSSGSAAGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLS------------ 602

  Fly   863 YRLLESE---------ADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQ 918
              :|..|         ..::.:.||...:|             |...|.:|:.:...|...:|.|
  Fly   603 --VLPEENHGNVPGHLKQQIQRQREQHQQH-------------QRDLLQQEQTSSPLPQRRSPEQ 652

  Fly   919 KQIFSLMKFDS---------YQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSK 974
            ..:.::.:.||         |||.      .||:.:.:       ||.|.|. ..|...||  :.
  Fly   653 AMLNNVSRNDSITSKDWEPLYQRL------SSCLSSNE-------SGYDSDG-GATGARLG--NN 701

  Fly   975 LKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQN 1039
            |..|..:.|.                                          :.|.:||    :|
  Fly   702 LSISGGDTES------------------------------------------IASGTLK----RN 720

  Fly  1040 SLSDLHSSRSSLSSFDAGTATG---GQGASTESVYSLCRV-ILTDGATTIVQTRPGETVGELVER 1100
            ||..|.||..      .|...|   |.||.:....|:|.. :...|.....:|   ||:.....:
  Fly   721 SLISLSSSEG------VGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYET---ETIRRRFRQ 776

  Fly  1101 LLEKRNLVYPYYDIVFQGST--KSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKK 1163
            :..:|.....|..||....|  .:.:.||...::...|.....:...:|.|.| ::::|..|..:
  Fly   777 VKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGD-EIVNVNGKHLR 840

  Fly  1164 --QLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADG---QRLRIVMVNSDFQVGGGS 1223
              |....::.:||.:......:.:...:.....|....:.: ||   ||.|:..|.........|
  Fly   841 GIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRI-DGMSTQRHRLSYVQRTQSTDSLS 904

  Fly  1224 SMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADA--AASEKSRPVDLCSMKSNEAPSETSSL- 1285
            ||...|.:..:  .|||..|...:...|   .:.||  .||..:.|..:..|:...:.:...||
  Fly   905 SMQSLQLQQER--IQGHNTEQEQEAQGE---DQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLD 964

  Fly  1286 -----FERMRRQQRDGG---NIPASKLPKLKKKSTSSS---------QQSEEAATTQAVADPKKP 1333
                 .|.:||:.|...   ::..:..|.....|:|.|         .:::.|..|    |...|
  Fly   965 VGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLDNENDPANDT----DSYTP 1025

  Fly  1334 IIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPD---------FLKNKE 1389
            :.|...|.|  .|...:|:  ||     |...|||.....|:.:: ..|:         :.:|..
  Fly  1026 VYANRAASV--CVASSLAD--DE-----KWQLLARKRCSEGSALS-ATPNPQQFGQRTHYARNSI 1080

  Fly  1390 NLSAAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQ 1454
            ||  |.|..|.:|.:.|.:|   ::...:...||..|:|..:...:.........|||....|.|
  Fly  1081 NL--ANSHYRSLRFAHSRLS---SSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQ 1140

  Fly  1455 TEFAKAPPPLPPK--PKVLPIKPSNWGVAQPTGNYCNKYSPSKQVPTS--------PKEAS---- 1505
            ....:....|..|  ||.:.:...|        .|.|..|......||        |..|:
  Fly  1141 QNQQQTHQSLYIKHSPKSVSLFSPN--------PYVNASSSPASASTSAGAGSSLAPPAAALMHH 1197

  Fly  1506 KPGTFASKIPL------DLGRKSLEEAGSRC 1530
            :|....:|:.:      ::.|.|:.|...||
  Fly  1198 RPSLPVAKLTIRDEEMAEVIRASMSEGSGRC 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984	26/160 (16%)
		RGS_R12-like	828..941	CDD:188661	21/131 (16%)
		RGS12_RBD	1073..1145	CDD:176412	13/74 (18%)
		RBD	1144..1213	CDD:128731	14/73 (19%)
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	16/90 (18%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900