DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and CG34375

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001163693.1	Gene:	CG34375 / 42715	FlyBaseID:	FBgn0085404	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	97/521 - (18%)
Similarity:	169/521 - (32%)	Gaps:	175/521 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYY 149
            :||.|        :.|.||:.|:|.||.|:.:||.:|           :|.....:..::.:::.
  Fly    30 VSGVQ--------AKSSAERGGVRLGDTLLELNGADV-----------LGLKISELANRLQDHWQ 75

  Fly   150 S----------------DSSDE--ENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLN 196
            |                |.:::  |.:||...| :...||:.....|.|.::|          |.
  Fly    76 SGAEVVTLMMWRQQANIDPNEDPAEASHAVQHG-INQQSLQKFATCLQHISQL----------LE 129

  Fly   197 PPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALE---CRVIVGYL 258
            .|..:|..|                ||       .....|...:.....|.:::   |||.:|..
  Fly   130 CPVCLEVIK----------------PP-------GWQCCNGHVLCNNCRSRSVKCPVCRVPLGPR 171

  Fly   259 G----------------------TIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDS 301
            |                      |.::.....| .||.:|..|..:..   .||.:.|
  Fly   172 GRCLLSDKLFTLLAESFPCDGGKTNKVAASQGH-GKLSSVNKCTNEYH---NQPKMAL------- 225

  Fly   302 LSLQSSSG-------------GVLATYSSARLNFVSSSSESENRFFGLVTSAV--HNTQIEEEYE 351
              .::|||             .||...|...:...|...:.:.:   .|..||  ..|.|:.:::
  Fly   226 --AKTSSGKSKCGKQISRQLETVLVDQSPREIRRKSQQGQEQEQ---AVQEAVLPRCTLIKVQHQ 285

  Fly   352 PSAGSAAAAGHIS-ISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVV 415
                 .||..|.| ..|:..:.....||.:.:..:....:..|:|  |.::.:     ||...|.
  Fly   286 -----EAAVEHFSEEGHNNMLVKPKLKLSKKSWRITGPDQDGLRC--DEVATI-----NNGVQVQ 338

  Fly   416 NLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNN 480
            ...:.....::....|.|.:::|:   ......|...::||.|               .|....|
  Fly   339 EQQQQQERQQLGHEKSASSESEYQ---NYHCPTGKSCSSHSYQ---------------LGQPVAN 385

  Fly   481 DCTNISDRILVVDFLAAGAGAAAAAHAGPPT------YPAPARPLG---------IVGIPDNRLT 530
            ..:.::.:.|.|...:.||..:|.:|...|.      .|..|..:|         :.|  |:||.
  Fly   386 KLSTVAMQALAVVENSGGASLSAGSHKQAPAAGVNQELPLEAGSIGRREWQLLRHLSG--DHRLA 448

  Fly   531 V 531
            |
  Fly   449 V 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	15/59 (25%)
		PTB_RGS12	251..391	CDD:269984	33/177 (19%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
CG34375	NP_001163693.1	PDZ	13..86	CDD:238080	16/74 (22%)
CG34375	NP_001163693.1	RING	129..168	CDD:238093	10/61 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900