Protein Alignment loco and Syn1

DIOPT Version :9

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Alignment Length: 566
• Identity: 102/566 - (18%)
• Similarity: 158/566 - (27%)
• Gaps: 234/566 - (41%)

  Fly    12 GASGSTAVGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNG-------- 68
            |..|:...|||........|.:.|........|...||.|..:..|.....|.|..|
  Fly    88 GGGGAGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMC 152

  Fly    69 ------------IRTVEVRRGYNGFGFTISG----QQPCRLSCIISSSPAEQA-GLRSGDFLISV 116
                        :|.  ::...||.|.:|.|    :.|..:|.|.....|:|| ||..||.:::|
  Fly   153 DVPDHVANQKRHVRI--IKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTV 215

  Fly   117 NGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHK 181
            ||..:....|:..|:.:..|...:.:::                               :||..
  Fly   216 NGEELRDATHDEAVRALKRSGRVVDLEV-------------------------------KFLRE- 248

  Fly   182 AKLHRLRNSPQKKLNPPEAVEPHKSKSS------------------PDHPTLKPVLEDPPLTANL 228
                               |.|:..|:|                  |..||..|..:..|
  Fly   249 -------------------VTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKTTP----- 289

  Fly   229 SKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIV 293
              .||                          |..:|.|::|.::
  Fly   290 --RAD--------------------------TRYIPLQLTHLAR--------------------- 305

  Fly   294 LMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVT-SAVHNTQIEEEYEPSAGSA 357
                                     .|.::    :.|||.|.|.: ..||:..:.     :|.||
  Fly   306 -------------------------NLKYI----DPENRCFELHSPDGVHSCILR-----AADSA 336

  Fly   358 AAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMY 422
            .|....:..||.           .....|||                |...|.:  :.||:..:.
  Fly   337 EALVWFNALHSA-----------MGTSTQRA----------------LAEANRA--LTNLIGELK 372

  Fly   423 TMRILPPASRSHQADYEAGAGAAAAG----GAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCT 483
            .:..|........:...||.|||:.|    .:|.|.....||..|    ::.:||.
  Fly   373 HIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSPSGRS----SSESSDE--------- 424

  Fly   484 NISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRL 529
              ||:.|.: |:|..........:.|.:..|.:|||.|..:...||
  Fly   425 --SDKWLPI-FVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	22/80 (28%)
		PTB_RGS12	251..391	CDD:269984	21/140 (15%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	22/113 (19%)
		PHsplit_syntrophin	<293..351	CDD:269960	18/123 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900