DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and dysc

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	195/1002 - (19%)
Similarity:	292/1002 - (29%)	Gaps:	368/1002 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPITGASGSTAVGTGA-----AAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYN 67
            |.:.||:.|::|.|.:     ....|........||....|||......::.:|.|.. .|.:..
  Fly   229 LRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSV-PNIHEL 292

  Fly    68 GIRTVEVRRGY---NGFGFTISGQQPCRLSCIIS----SSPAEQAGLRSGDFLISVNGLNVSKLP 125
            ..|||.:.|..   :|||..:.|.:...|...||    :|.||:||||.||.::.|||...:.:.
  Fly   293 TTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSIN 357

  Fly   126 HETV----VQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHR 186
            ||..    ||::.:|     .||:              .|:|.          |..|:..|.||
  Fly   358 HEEALKRCVQILKSS-----RQIS--------------MTVRA----------PPTLNSTAPLH- 392

  Fly   187 LRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALEC 251
                   ...||.....:.|.:.|.||            .|.:.||      |...|...|.|..
  Fly   393 -------GFGPPSRDPMYASMAPPLHP------------QNQAAAA------AAAAAASGAGLPF 432

  Fly   252 RVIVGYLGTIEMPKQ--ISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITP-DSLSLQSSSG---- 309
            |....::.....|..  :.:..:....|..||:          |.:.|.| .||.|....|
  Fly   433 RQTCSWMDRHGRPASPPMEYGGRRSERRDRIRR----------VELLIEPGQSLGLMIRGGVEYG 487

  Fly   310 -GVLAT----------------------YSSARLNFVSSSSESENRFFGLVTSAVHN-------- 343
             |:..|                      ...:.|:.....:..:.::...::..:.:
  Fly   488 LGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSC 552

  Fly   344 TQIEEE----YEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEF-----------RL 393
            |.||.|    |.|:...|...|.|:           |.:.|.|:.|...|.|           ..
  Fly   553 TSIEMEPWDAYSPTGTRARRKGQIA-----------TMVEEKARSLLPRHHFASLSYYIAEYSAK 606

  Fly   394 QCTRDPISNLCLE------------------FPNN----SEYVVNLVRSMYT------------- 423
            ..|.|....:.||                  ||.:    .|.|....|..|:
  Fly   607 AMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARD 671

  Fly   424 -------MRILPPASRSHQADYEAGAGAAAAG----GAVAAAHSP----------QPSNHSEIST 467
                   :.|:....||..:|  :|.|.....    .|:...|.|          ||::|.:..:
  Fly   672 LPVTADDLEIIAATGRSPSSD--SGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGS 734

  Fly   468 TTSNSD------------------------SGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAG 508
            ..|:|.                        .|||.|                 .|:|    .|..
  Fly   735 NQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGN-----------------VGSG----RHHH 778

  Fly   509 PPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRS--------PPASSSLRRPNLLASFNLIQSP 565
            .|..|:   .|......||:.......:|.....|        |.|...| ...|..||::.:..
  Fly   779 HPLGPS---QLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAEQEL-ATKLSRSFDMKEEG 839

  Fly   566 ATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAH-PACVPRKMRRSLA 629
            .|.|                ..:.:....||..:|......|..| .|..| |..|| ..|.:|.
  Fly   840 GTLL----------------GDKGVRRHQSMQRLSAEQNGGSTTE-QTHEHNPNVVP-DHRGNLH 886

  Fly   630 LETPTTPHKLSAQVFGQPGSRHSL-----------GFEA----IDSVQSSVSGACMDQTMDTWAS 679
            :....|...|...:.|...::|.|           .|||    :..:...|.|          ..
  Fly   887 ITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDG----------TK 941

  Fly   680 LQNLHKSHKDRTSMSA--------SSSSHCLLEA--TNSEPD---------LGNRALPANASPFR 725
            ::.||  |::...:.|        :..:..::||  :|.||.          ...|||| :.|..
  Fly   942 VEGLH--HQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEAXHLLALPA-SDPLE 1003

  Fly   726 R-------AWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNA---------SDNDMYIKTLML 774
            |       .||.....||:.           ..:|:..|.:.|.         :.|..|..:..|
  Fly  1004 RQKLEFLYEWGIDLTETPKP-----------MPTPIPLTKAKNPPPLPHELHNNINSQYGSSAAL 1057

  Fly   775 DSDLKSSRSQHQLSLLQVPKVLTTPAP 801
                    |.||      |...|.|.|
  Fly  1058 --------SNHQ------PHQHTHPHP 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	29/86 (34%)
		PTB_RGS12	251..391	CDD:269984	29/181 (16%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	31/104 (30%)
		PDZ_signaling	466..543	CDD:238492	10/76 (13%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	16/90 (18%)
		PDZ_signaling	886..971	CDD:238492	14/96 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900