DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and baz

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster

Alignment Length:	1566	Identity:	293/1566 - (18%)
Similarity:	476/1566 - (30%)	Gaps:	545/1566 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HHPPLPITGASGSTAVGTGAAA--AEDASPAANSGPAPISTSTTPSGSNSQQH------------ 54
            :|.|...:|......:|.|...  .|.|....|..||   ..|...||:...|
  Fly   249 NHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPA---QQTYQQGSHHAGHGQNGAYSSKSLP 310

  Fly    55 -QRRRKKRANYNYNGIRTVE-----VRRGY-------------NGFGFTISGQQPCRLSCIISSS 100
             :.:||:.....|..||..:     :...|             :|.|..:...:|        .|
  Fly   311 RESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEP--------GS 367

  Fly   101 PAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIA-------ENYYSDS------ 152
            .||:..||..|.::.:||:.:..|....|.:.:..:..|..:::.       .....||
  Fly   368 RAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMV 432

  Fly   153 -----SDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQ-------KKLNP-------- 197
                 |.....||...|..|..:   ..|.|..|.:: .|:..|.       .:.||
  Fly   433 EVATVSPTRKPHAAPVGTSLQVA---NTRKLGRKIEI-MLKKGPNGLGFSVTTRDNPAGGHCPIY 493

  Fly   198 -----PEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGY 257
                 |........:..|....|:  ::..|:|....     .:|.|::|.:.:.| ..|::|.
  Fly   494 IKNILPRGAAIEDGRLKPGDRLLE--VDGTPMTGKTQ-----TDVVAILRGMPAGA-TVRIVVS- 549

  Fly   258 LGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSL-----------QSSSGGV 311
             ...|:.:|....:              ||.....|...:.|.::..           :|||...
  Fly   550 -RQQELAEQADQPA--------------EKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARS 599

  Fly   312 LATY-SSARLN----FVSSSSESENRFFGLVTSA--------------VHNTQIE---------- 347
            |.|: ..::||    |:.:.|||......|..|:              ||:|:..
  Fly   600 LFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKT 664

  Fly   348 -EEYEPSAGSAAAAGHISISH--SCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPN 409
             .....|..||::..:..:.|  ...:||   |.:.|.....|....|:......::.:.|...|
  Fly   665 CSNLNASGSSASSGSNGLMKHDGDLGIFV---KNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQN 726

  Fly   410 NSEYVVNLVRSMYT--------------MRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPS 460
            |:|.:..|.|:|..              .:||..||.|...|:             :.:||...|
  Fly   727 NAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDH-------------SNSHSHSHS 778

  Fly   461 NHSEISTTTSNSDSGIGFNNDCTNISDRI-LVVDFLA----------AGAGAAAAAHAGPPTYPA 514
            |    |:..|||:.....||..:|.||.. ..|.:|:          .|.|.:|.......:.|.
  Fly   779 N----SSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPV 839

  Fly   515 PARPLGIVGI-------PDNRLTVRAMPDHS----ALLRSPPA----SSSLRRPNLLASFNLIQS 564
            ..|..|  ||       |.::.:.:..|..|    ...|.|.|    |::||..:...:.|...|
  Fly   840 LDRLTG--GICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWS 902

  Fly   565 PATNLTSTRSCDDVLNLFVDD----SPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMR 625
            ||.....|...:..| |..||    ||...|........:..||.||
  Fly   903 PAQMHLMTAHGNTAL-LIEDDAEPMSPTLPARPHDGQHCNTSSANPS------------------ 948

  Fly   626 RSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDR 690
            ::||:.....|..   .|.|.|.:  |..|:|..|.|.|         ::|.:.:::..:....|
  Fly   949 QNLAVGNQGPPIN---TVPGTPST--SSNFDATYSSQLS---------LETNSGVEHFSRDALGR 999

  Fly   691 TSMSASSSSHCLLEAT------------------------------NSEPDLGNRALPANA--SP 723
            .|:  |...|..|:|.                              .|...|..|...|||  |.
  Fly  1000 RSI--SEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSG 1062

  Fly   724 FRRAWGQSSFRTPRSDK-----VAKEQQQLGQSSP---VRRTASMNASDNDMYIKTLMLDSDLKS 780
            ::.|...||.....:.:     .|:.:.|||...|   :::::|:.:      ::|::.:..:..
  Fly  1063 YKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLES------LQTMVQELQMSD 1121

  Fly   781 SRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQ-----------DH--GCPSSWAGSFERML 832
            ....||  .|:.|:   ......::.|:|.:|..|.           ||  |..|...|.|:..|
  Fly  1122 EPRGHQ--ALRAPR---GRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEGGFASQRNGPFQSSL 1181

  Fly   833 QDAA-GMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDS 896
            .|.. |.:  |...||......|     ...:|..::..|.|     :...:.|.|.|.|.:|.|
  Fly  1182 NDGKHGCK--SSRAKKPSILRGI-----GHMFRFGKNRKDGV-----VPVDNYAVNISPPTSVVS 1234

  Fly   897 QARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDE 961
            .|.|          |.:....|:|:                      :..|:.|.:|.:.|
  Fly  1235 TATS----------PQLQQQQQQQL----------------------QQHQQQQQIPTAAL---- 1263

  Fly   962 LLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAP 1026
                               .|.:|..|                       ..|..|.||:|....
  Fly  1264 -------------------AALERNGK-----------------------PPAYQPPPPLPAPNG 1286

  Fly  1027 LTSASLKLVCGQNSL-----------SDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTD 1080
            :.|..:.    ||.:           .|||.....      ...:||                 |
  Fly  1287 VGSNGIH----QNDIFNHRYQHYANYEDLHQQHQQ------HQISGG-----------------D 1324

  Fly  1081 GATTIVQTRPGETVGELVERLLEKRNLV------YPYYDIVFQGSTKSIDV--------QQPSQI 1131
            ..|:|.:|....|:..:.::::.:|..|      :.:|.  .|.|.:|.||        .||..:
  Fly  1325 STTSISETLSESTLECMRQQVIRQRIKVEAESRRHQHYH--SQRSARSQDVSMHSTSSGSQPGSL 1387

  Fly  1132 LAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDL 1196
                                       ::|:.|.:.| ||:.|.|.|:..|.|
  Fly  1388 ---------------------------AQPQAQSNGV-RPMSSYYEYETVQQQ------------ 1412

  Fly  1197 NQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAA 1261
                                 :||.              :...|....|:...:.:......|||
  Fly  1413 ---------------------RVGS--------------IKHSHSSSATSSSSSPINVPHWKAAA 1442

  Fly  1262 SEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQA 1326
            .....|..|.|...:..|..|....    |:|..|| |||..|.:.:::..  .||.....|.|.
  Fly  1443 MNGYSPASLNSSARSRGPFVTQVTI----REQSSGG-IPAHLLQQHQQQQL--QQQQPTYQTVQK 1500

  Fly  1327 VADPKK 1332
            ::.|.:
  Fly  1501 MSGPSQ 1506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	17/93 (18%)
		PTB_RGS12	251..391	CDD:269984	33/182 (18%)
		RGS_R12-like	828..941	CDD:188661	22/113 (19%)
		RGS12_RBD	1073..1145	CDD:176412	15/85 (18%)
		RBD	1144..1213	CDD:128731	10/68 (15%)
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	14/78 (18%)
		CRS1_YhbY	<390..>436	CDD:294440	5/45 (11%)
		PDZ_signaling	462..548	CDD:238492	15/94 (16%)
		PDZ_signaling	<686..753	CDD:238492	13/69 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900