DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and CG5921

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster

Alignment Length:	1000	Identity:	181/1000 - (18%)
Similarity:	303/1000 - (30%)	Gaps:	389/1000 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ITGASGSTAVGTGAAAAEDAS---------PAANSGPAPISTSTTPSGSN--------------- 50
            :|..:.|.::.|.|:....||         ...:|..:.:.|.||.:.|:
  Fly     2 MTMTAASASISTSASLTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRL 66

  Fly    51 SQQHQRR-----RKKRANYNYNGIRTVEVRRG-YNGFGFTISGQQPCRLSCIISSSPAEQAGLRS 109
            .:.||||     .::.:.|.:.      ||.| .:|.||.:|.        :.....|...|||.
  Fly    67 VRPHQRRLLVGGPERGSTYGFT------VRGGREHGTGFFVSH--------VEHGGEAHLKGLRI 117

  Fly   110 GDFLISVNGLNVSKLPHETVVQLIGN------------------------SFGSIRMQIAENYYS 150
            ||.::.:||..:....|:..:||:..                        |:..:::.......|
  Fly   118 GDQILRINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPS 182

  Fly   151 DSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKL----------NPPEAVEPHK 205
            :||        .:|:...|| |.....||         .:|:.||          .|...|:..|
  Fly   183 ESS--------FKGERRGAS-RDISVVLH---------VAPRTKLGLGICKGPEWKPGIFVQFTK 229

  Fly   206 SKSSPDHPTLKPVLEDPPLTAN--------LSKAADVANVSAMVRAVGSAALECRVIVGYLGTIE 262
            .:|......|:|  .|..|:.|        .|:|..|...|:.:..|...|..|.:..|
  Fly   230 DRSVAREAGLRP--GDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPG------ 286

  Fly   263 MPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYS-------SARL 320
                                                 :|....||:..|....|       |.||
  Fly   287 -------------------------------------ESSGYNSSASSVTGDQSPCWADAKSKRL 314

  Fly   321 NFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHL 385
            ..|...|.:.....||.::            |.|||...:..:.:....:..:|  ||.|:...:
  Fly   315 TAVREESGAGGGGCGLSSA------------PGAGSPNWSQGVEVHKQMNKTII--KLTENGTSI 365

  Fly   386 QRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGA 450
                                    |:.|:.:...|..                 :|:|:..:|.:
  Fly   366 ------------------------NNTYIASTGGSSV-----------------SGSGSTGSGTS 389

  Fly   451 VAAAHS-PQPSNHSEISTT--------TSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAH 506
            ..:..| ..|||.|..|||        .:::.||||.::..             |..||:|.::.
  Fly   390 GRSQQSQSNPSNPSRNSTTMKRSHLRPVNSAGSGIGLSSGS-------------AGSAGSAGSSG 441

  Fly   507 AGPPT----YPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPAT 567
            :|..:    .||||.|                         |||.:.        ..|...|..:
  Fly   442 SGSRSGGVIAPAPAPP-------------------------PPAMNE--------GANASGSVGS 473

  Fly   568 NLTS----------------------TRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDE 610
            :|:|                      .|..|...|..||   |.|..         |:.    :.
  Fly   474 SLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVD---RQLTG---------HNG----NG 522

  Fly   611 GHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSV-----------QSS 664
            ||            |.|:.    ...|:..|.|.|...:..  |.|.|.::           .:.
  Fly   523 GH------------RSSVG----QVSHRQRANVAGVAATLQ--GSERISNLTGGGGAGGAGGSNG 569

  Fly   665 VSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRR--- 726
            .:||..||..   |.:....::|:.........|.|.|  ::..:..|.:|:|........|
  Fly   570 AAGAGGDQHT---ALMDEFKRAHQRMFRNGFHESEHKL--SSLGKSSLADRSLYGREMSLLRVKN 629

  Fly   727 ---AWGQSSFRTPRSDKVA--------KEQQQLGQSSPVRRTA----------SMNASDNDMYIK 770
               ..|:.|...|....|:        ...|:.|::  ::||:          |:|:::|:.:.:
  Fly   630 GGSGGGEGSGVMPTMRPVSMGRPLVTMSTYQERGET--LKRTSIMPDESCYRNSINSNNNNGFSR 692

  Fly   771 TLMLDSDLKSSRSQHQ-----------LSLLQVPKVLTTP----APPSAI---TASVAAEGAAQD 817
            .....:...::|.|.|           ..|...|.....|    .||..|   |.:.||.|:...
  Fly   693 NRSNSNTNNNNRLQSQNGVNPANGNGSPELPPPPPQFANPQPKQMPPQHIKPMTGNAAANGSGSA 757

  Fly   818 HGCPSSWAGSFERMLQDAAGMQTFS 842
            :|..:   ||..::.|..:.|::.|
  Fly   758 NGLGN---GSLAKVRQPMSPMRSAS 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	19/100 (19%)
		PTB_RGS12	251..391	CDD:269984	22/146 (15%)
		RGS_R12-like	828..941	CDD:188661	2/14 (14%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	19/83 (23%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	19/89 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900