DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Ush1c

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	114/665 - (17%)
Similarity:	217/665 - (32%)	Gaps:	212/665 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   988 KSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLT-SASLKLVCG---QNSLSDLHSSR 1048
            |..:.:.:.|..:||...|:..|..|        |:...|: ...|:..||   .:.:....:..
  Rat    69 KHQVEYDQLTPRRSRKLKEVRLDRLH--------PEGLGLSVRGGLEFGCGLFISHLIKGGQADS 125

  Fly  1049 SSLSSFDAGTATGGQGAST---ESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYP 1110
            ..|...|......|...|:   |.|.:|.|.    ..|..::.|   .:|.:..:...:..|.:.
  Rat   126 VGLQVGDEIVRINGYSISSCTHEEVINLIRT----KKTVSIKVR---HIGLIPVKSSPEEPLKWQ 183

  Fly  1111 YYD--IVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKL-------------DLPDPKVISVKSK 1160
            |.|  :...|..:. .:..|     |.....|::|...|             .:..|.:.....|
  Rat   184 YVDQFVSESGGVRG-GLSSP-----GNRTTKEKKVFISLVGSRGLGCSISSGPIQKPGIFVSNVK 242

  Fly  1161 PKK-----------QLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDL----NQPVTMADGQRLRI 1210
            |..           |:.||.....:..::| |.|.|:.....:.|.:    .:.:.|.|.:||
  Rat   243 PGSLSAEVGLETGDQIVEVNGIDFTNLDHK-EAVNVLKSSRSLTISIVAGAGRELFMTDRERL-- 304

  Fly  1211 VMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNEL----------LASKADAAASEKS 1265
                        ......:.:..:.|.|..|...:||:..|.          :|.|| |..:|:.
  Rat   305 ------------EEARQHELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKA-AEENERY 356

  Fly  1266 RPVDLCSMKSNEAPSETSSLFERMRRQQRDGGN----------------IPA------------- 1301
            |       |..|..||....|:  ::.:.|.|:                :|.
  Rat   357 R-------KEMEQISEEEEKFK--KQWEEDWGSKEQLILPKTITAEVHPVPLRKPKSFGWFYRYD 412

  Fly  1302 SKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQL 1366
            .|.|.::||:....:...:  :.|.:...||          :|:..:::.:.::|:||..|:.::
  Rat   413 GKFPTIRKKAKEKKKAKYD--SLQDLRKNKK----------ELEFEQKLYKEKEEMLEKEKQLKI 465

  Fly  1367 ARLEDQRGTEINFDLPDFLKNK-----------ENLSAAVSKLRKVRA-------SLSPVSK--- 1410
            .||..:.......||.:..|.:           :.:|:|.:::.::..       |:||:..
  Rat   466 NRLAQEVSETEREDLEESEKTQYWVERLCQTRLQQISSAENEITEMTTGPPPPPPSVSPLVPPLR 530

  Fly  1411 -----------------------VPATPTEIP-QPAPRLSITRSQQPVSPMKVDQEPETD-LPAA 1450
                                   .|.||:.:| .|.|..|...|:.|..|:.    |.:| :.::
  Rat   531 RFAGGIHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPSKVPAPPVL----PSSDHMSSS 591

  Fly  1451 TQDQTEFAKAPPPLPPKPKV-----LPIKP-----------------------SNWGVAQPTGNY 1487
            :....:....|.|:||.|.:     .|.:|                       ::|.....:|..
  Rat   592 SSPWVQHTPPPIPIPPPPSIPTQDLTPTRPLPSALEEVLGNHPFRTGDPGHPATDWEANTHSGKP 656

  Fly  1488 CNKYSPSKQVPTSPK 1502
            .:..:|.:..|.:||
  Rat   657 TSSPTPERSFPPAPK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412	13/73 (18%)
		RBD	1144..1213	CDD:128731	16/96 (17%)
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819	2/10 (20%)
		PDZ_signaling	85..165	CDD:238492	17/91 (19%)
		PDZ_signaling	209..289	CDD:238492	14/80 (18%)
		Cgr1	<316..>358	CDD:281823	12/49 (24%)
		PDZ_signaling	751..838	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900