DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Pard3b

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001178737.1	Gene:	Pard3b / 301455	RGDID:	1584992	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	185/989 - (18%)
Similarity:	296/989 - (29%)	Gaps:	388/989 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PLPITGASGSTAVGTGAA----AAEDASPAANSGP-------APISTSTTP-SGSNSQQHQRRRK 59
            |.|..|.:|..||....|    ..|..||..:..|       .|.|.|.:| .|..|:::.::.|
  Rat   319 PPPTRGKAGLKAVNPTRANSPEGEESPSPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIK 383

  Fly    60 KRANYNYNGIRTVEVRRGYNGFGFT-------ISGQQPCRLSCIISSSPAEQAG-LRSGDFLISV 116
                        :::::|..|.|||       |.|..|..:..|:....|.:.| |:|||.::.|
  Rat   384 ------------IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEV 436

  Fly   117 NGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASL-RHKPRFLHH 180
            ||.:|:....|.:|.::                         .:|.:|:.::..: |.:..||
  Rat   437 NGRDVTGRTQEELVAML-------------------------RSTKQGETVSLVIARQEGSFL-- 474

  Fly   181 KAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVG 245
                                  |.:.|..||...|           :|..:..:
  Rat   475 ----------------------PRELKGEPDCYAL-----------SLESSEQL----------- 495

  Fly   246 SAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGG 310
                          |:|:|...|.|:.|..      .|:..|.:.|...:.|...|:    ..||
  Rat   496 --------------TLEIPLNDSGSAGLGV------SLKGNKSRETGTDLGIFIKSI----IHGG 536

  Fly   311 VLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVID 375
              |.:...||..                    |.|:          .|..|...:..|.|
  Rat   537 --AAFKDGRLRM--------------------NDQL----------IAVNGETLLGKSNH----- 564

  Fly   376 TKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEA 440
                |..:.|:|:                :....|       :|.|..:.||....|..:...|.
  Rat   565 ----EAMETLRRS----------------MSMEGN-------IRGMIQLVILRRLERPLEEISEC 602

  Fly   441 GAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAG-AAAA 504
            |           |...|...|..|..:.:..:||.:.:  .|...|.:....|.|....| |...
  Rat   603 G-----------ALSRPCFENCQEALSASRRNDSSLLY--PCGTYSPQDKRKDLLLPSDGWAENE 654

  Fly   505 AHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLI----QSP 565
            ....||  |.|:...|             :.|.|   .|....|:...|:...:|.::    |..
  Rat   655 VPPSPP--PHPSLEWG-------------LEDFS---HSSRVDSTGYFPDQHVNFRIVTPVGQPE 701

  Fly   566 ATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLAL 630
            :.||.:::|.|    |..|:|     .|.|:.|  ..|.:|..|.|.|..        :::|.:|
  Rat   702 SINLKASKSMD----LVPDES-----KVQSLAD--RRSDSPGKDFGPTLG--------LKKSSSL 747

  Fly   631 ETPTTPHKLSAQV------FGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKD 689
            |:..|   ..|:|      |.:|......|....:|.:     |.:|::.|      ...::..|
  Rat   748 ESLQT---AVAEVRKNDLPFHRPRPHMVRGRGCNESFR-----AAIDKSYD------GPEEAEAD 798

  Fly   690 RTSMSASSSSHCLL---EATNSEP---DLGNRALPANASP------------------------- 723
            ..|..:|.|.|..|   .|....|   |:.|:|.....:.
  Rat   799 GLSDKSSHSGHTALNCESAPQGNPELDDVENKAKNVKKTKEKEKKKGKGKMKVKEKKQKEEHEDT 863

  Fly   724 ----FRRAWG-QSSFRTPRSDKVAKEQQQLGQSS-----------------------PVRR---- 756
                .|:.:| ...|...:.|||.|.:|:..|.|                       .:|.
  Rat   864 ERKMKRKGFGAMLRFGKKKDDKVGKTEQKGTQKSGHPGEEELERMKEERERIGAKHQELREKQAR 928

  Fly   757 ---------TASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAE 812
                     |..::..|:|        :.|...:|..|.........|..:|:||.|.|.....:
  Rat   929 GLVDYATVATGPVHDIDDD--------EMDPNYARVNHFREPCTSANVFRSPSPPRAGTLGYPRD 985

  Fly   813 G----------------------AAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIY 855
            |                      |..|.|.|  .||:.:|:           :.|:||      |
  Rat   986 GRPLSPDHLEGLYAKVNKPYHPPALADSGRP--MAGTTDRI-----------QKLRKE------Y 1031

  Fly   856 FWTACERYRLLESE 869
            :....|.:.|.|.|
  Rat  1032 YQARREGFLLYEDE 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	21/83 (25%)
		PTB_RGS12	251..391	CDD:269984	25/139 (18%)
		RGS_R12-like	828..941	CDD:188661	9/42 (21%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873
		PDZ_signaling	201..288	CDD:238492
		PDZ	380..469	CDD:214570	24/125 (19%)
		PDZ_signaling	501..589	CDD:238492	25/161 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900