DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Pdzd7

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001099832.2	Gene:	Pdzd7 / 293996	RGDID:	1309882	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	1211	Identity:	236/1211 - (19%)
Similarity:	395/1211 - (32%)	Gaps:	377/1211 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 RILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEI----STTTSNSDSG-IGFNNDCTN 484
            |:|...||        |..|::..|.|...:||..:|..|.    :.....|.|| :||:  ...
  Rat    49 RLLNGPSR--------GIRASSPMGRVILINSPIEANSDESDIIHAVCVEKSPSGRLGFS--VRG 103

  Fly   485 ISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSS 549
            .|:..|.: |::.....::|..||             :.:.|....|..:.     |.|....|:
  Rat   104 GSEHGLGI-FVSKVEEGSSAERAG-------------LCVGDKITEVNGLS-----LESTTMGSA 149

  Fly   550 LRRPNLLASFNLI--------QSPATNLTSTRSC-DDVLN--LFVDDSPRTLAAVASMDDIS--L 601
            :|   ||.|.:.:        :.|....:..::. .||:|  |.|:....|.:..:|.|.:.  :
  Rat   150 VR---LLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCSSTPSDSSSEDGVRRIV 211

  Fly   602 HSAAPSLD--------EGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSR-----HSL 653
            |....|.|        .|..|.....|.:.....||.|...   |:..||....|.|     ||.
  Rat   212 HLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGI---KVGDQVLAANGVRFDDISHSQ 273

  Fly   654 GFEAI----------------DSVQSSVSGAC-MDQTMDTWASLQNLHKSHKDRTSMSA-SSSSH 700
            ..|.:                .:.:..||..| :|:..:  ..||.|..:.:..:|:|: :||:.
  Rat   274 AVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLDRLSN--GVLQQLSPASESSSSVSSYASSAP 336

  Fly   701 CLLEATNSEPD------LGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTAS 759
            |   ::.|.|.      ||... |.:..|   .||       |:|...:.:..:| .|.|....|
  Rat   337 C---SSGSLPSDRMDVCLGPED-PTSQGP---GWG-------RADTAMQTEPDMG-GSRVETWCS 386

  Fly   760 MNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPK-----VLTTPAPPSAITASVAAEGAAQDHG 819
            :..:   :.::...:.||..||......:|.:.||     .|:.|.||  ||.|       |.|
  Rat   387 VRPT---VILRDTAIRSDGPSSTRHLDSALSESPKTALLLALSRPRPP--ITRS-------QSH- 438

  Fly   820 CPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYF----------------WTACERYRLLES 868
             .:.|....:|. ::.:|.......|::..:..|::|                ||.
  Rat   439 -LTLWEEKKQRK-KEKSGSSGEKGALQRSKTLMNLFFKGGRQGRPAGDGHREAWTL--------- 492

  Fly   869 EADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRF 933
                              :|..|..|..:   |..||.....|            :.||.:::
  Rat   493 ------------------DSRSPTKVRPR---LDLEKAGSVGP------------VQKFVTWR-- 522

  Fly   934 IRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTR 998
            :|.|..:.......::......|.::||.::                 |.:.||..:....|:..
  Rat   523 LRRDRERGRALLSARSGSPSGQGPNVDEQMQ-----------------AWESRRPLIQDLARRLL 570

  Fly   999 SKSRDRTEIMADMQH------------------ALMPAPPVPQNAPLTSASLKLVCGQNSLSDLH 1045
            :..    |::|..:|                  |::..|          |.|.|      |.|:.
  Rat   571 TDD----EVLAVTRHCSRYVHEGGVEDLVRPLLAILDRP----------AKLLL------LRDIR 615

  Fly  1046 S--SRSSLSSFDAGTATGGQGASTESVYSL-CRVILTDGATTIVQTRPGETVGELVERLLEKRNL 1107
            |  :.:.|..||:..    .....|:..:| .|.:   |.:.:..||         :....||:|
  Rat   616 SVVAPTDLGRFDSMV----MPVEMEAFEALKSRAV---GPSALRPTR---------QDTPPKRHL 664

  Fly  1108 VYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPI 1172
            :.|..|  .:|....:.|...|:...|:  :.||....|:.|.       .|.|.   |:.|.|:
  Rat   665 ITPVPD--SRGGFYLLPVNSCSEDEDGE--IRERLGGLKVSLG-------ASAPH---HKGIPPL 715

  Fly  1173 LSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLP 1237
                             ..||:|.                    |.:..|:..||.|..|:.|.|
  Rat   716 -----------------QDVPVDA--------------------FSLRRGACAPPPQPPPVAPRP 743

  Fly  1238 QGHLDELTNKVFNELLA---SKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNI 1299
            ...         |.||.   |:.|...::...|...||...:.:.|.:.|     |.:.|..|
  Rat   744 PRP---------NWLLTEPPSREDTQQNQNQTPGQSCSRSRSHSRSRSGS-----RSRSRSQG-- 792

  Fly  1300 PASKLPKLKKKSTSSSQQSEEAATTQAVA------DPKK--PIIAKLKAGVKLQVTERVAEHQDE 1356
                    :.||....:....|..|.|.:      .|:|  |::.:...|   ||. :|...|:.
  Rat   793 --------RGKSAGCRRSPSPAPITTATSANGRYHRPRKARPLLPRPLDG---QVA-KVGVRQEP 845

  Fly  1357 LLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRKVRASLSPVSKVPATPTEIPQP 1421
            |..|:.:.    .||:.|.....:|.....:|...|..:|....:.:.:.|:.|:     |...|
  Rat   846 LENGIDQT----AEDEAGNATTGELRTVTLSKMKQSLGISISGGIESKVQPMVKI-----EKIFP 901

  Fly  1422 APRLSITRS-QQPVSPMKVDQEPETDLPAATQDQTEFA-------KAPPPLP-----PKPKVLPI 1473
            .....:.|: |.....:.||.|   .|...|..:....       ||..|:.     |.|.:||:
  Rat   902 GGAAFLCRALQAGFELVAVDGE---SLEQVTHQRAVDTIRRAYRNKAREPMELVVRVPGPGLLPL 963

  Fly  1474 KPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKI 1514
            . ||....:..|...:..|....:..:|.....|.|.|.::
  Rat   964 S-SNLRAIKGQGLAADSSSAHGPIEDTPILTQLPPTEARQL 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	18/128 (14%)
		RGS12_RBD	1073..1145	CDD:176412	16/72 (22%)
		RBD	1144..1213	CDD:128731	10/68 (15%)
Pdzd7	NP_001099832.2	PDZ_signaling	84..164	CDD:238492	20/103 (19%)
		PDZ_signaling	209..289	CDD:238492	17/82 (21%)
		HN_PDZD7_like	555..632	CDD:259824	17/100 (17%)
		PDZ_signaling	866..954	CDD:238492	18/95 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900