DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Mpdz

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_006238402.1 Gene:Mpdz / 29365 RGDID:3105 Length:2068 Species:Rattus norvegicus


Alignment Length:1946 Identity:349/1946 - (17%)
Similarity:599/1946 - (30%) Gaps:719/1946 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 ASPAANSGPAPISTSTTPSGSNSQQHQR----RRKKRANYNYNGIRTVEVRRGYNGFGFTISGQ- 88
            |..|....|||.|...|.|.|.|....|    .:|...:..::    ||:.:...|.|.||:|. 
  Rat   335 ARGAVEETPAPSSLGITLSSSTSTSEMRVDASTQKNEESETFD----VELTKNVQGLGITIAGYI 395

  Fly    89 -----QPCRL--SCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIA 145
                 :|..:  ..|..||..|..| ::.||.:::|:|.|:....::..|:::.::..::|:.:.
  Rat   396 GDKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLM 460

  Fly   146 ENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSP 210
            ....|..::..:...|.:...|.|....|..                      |::...:|.|  
  Rat   461 RKGASQEAEITSREDTAKDVDLPAENYEKDE----------------------ESLSLKRSTS-- 501

  Fly   211 DHPTLKPVLED--PPLTANLSKAADVANVSAMV----RAVG-------------------SAALE 250
                :.|:.|:  |.|:..|.:..||...:|::    |.:|                   ..:||
  Rat   502 ----ILPIEEEGYPLLSTELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLE 562

  Fly   251 CRVIVGYLGTIEMPKQISHSSKL-------------------QTVRSCIRKLRQEKRQPTIVLMC 296
            ..|...::.::.....:.||.||                   |.|.:.:::|..:     :.::|
  Rat   563 ATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPID-----VTMVC 622

  Fly   297 ----ITP------DSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYE 351
                :.|      |||.:....   |.......|.....|||:|:..  |..|.| :...||...
  Rat   623 CRRTVPPTALSEVDSLDIHDLE---LTEKPHIDLGEFIGSSETEDPM--LAMSDV-DQNAEEIQT 681

  Fly   352 PSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVN 416
            |.|...|....|.:...                 .|...|.:...:|||.      |.|:   |.
  Rat   682 PLAMWEAGIQAIELEKG-----------------SRGLGFSILDYQDPID------PANT---VI 720

  Fly   417 LVRSMYTMRILPPASRSHQAD------------------YEAGAGAAAAGGAVAAAHSPQPSNHS 463
            ::||:....|.....|....|                  .||..||.:....:..| .|.|.:..
  Rat   721 VIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVA-KPLPLSPE 784

  Fly   464 EISTTTSNSDSGIGFNNDC--TNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPD 526
            | ...::..|:.:...:.|  ..:||:.|   |.|                     .|.::..||
  Rat   785 E-GYVSAKEDTFLCSPHTCKEMGLSDKAL---FRA---------------------DLALIDTPD 824

  Fly   527 ------NRLTVRAMPDHSALLRSPPASSSLRRPNLLASFN----LIQSPATNLTSTRSCDDVLNL 581
                  :|...:..||:.::..:..:..||.........|    |..||..::|:  |.|.||.|
  Rat   825 AESVAESRFESQFSPDNDSVYSTQASVLSLHDGACSDGMNYGPSLPSSPPKDVTN--SSDLVLGL 887

  Fly   582 FVD---------------DSPRT--LAAVASMDDISLHSAAPSLDEGHTFAH-----PACVPRKM 624
            .:.               .||.|  ..|..|...:|.::.|.::::.:..|:     |:.:|..:
  Rat   888 HLSLEELYTQNLLQRQHAGSPPTDMSPAATSGFTVSDYTPANAVEQKYECANTVAWTPSQLPSGL 952

  Fly   625 RRS-LALETP-TTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDT---WASLQNLH 684
            ..: ||...| ..|..|:.|        .||..:|......|:|....::|:..   .:||....
  Rat   953 STTELAPALPAVAPKYLTEQ--------SSLVSDAESVTLQSMSQEAFERTVTIAKGSSSLGMTV 1009

  Fly   685 KSHKDRTSMSASSSSH--------------CLL--------EATNSE------------PDLGNR 715
            .::||...:...|..|              |:|        ..||::            ||:...
  Rat  1010 SANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKFS 1074

  Fly   716 ALPA---------------NASPFRRAWGQ----------------------------------- 730
            |.||               :...||.::||                                   
  Rat  1075 AAPADDRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESEL 1139

  Fly   731 -----SSFRTPRSDKVAKE-QQQLGQSSPVRRTASMNASDND----MYIKTLMLDS--------- 776
                 ||:..||..::.:| .:.||.|....|......|:.:    ::||.::.||         
  Rat  1140 QNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1204

  Fly   777 -----------DLKSSRSQHQL---------------SLLQVPKVLTTPAPPSA----------- 804
                       ||:.:..:..:               |::..|:....|:.|.:           
  Rat  1205 PGDRIVEVDGMDLRDASHEQAVEAIRKAGSPVVFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTN 1269

  Fly   805 -------ITASVAAEGAAQDH------GCPSSWAGSFERMLQDAA--GMQTFSEFLKKE----FS 850
                   :|:..|...:..:.      ..|||....|..|..|.|  ...|.:|...||    :|
  Rat  1270 PFAESLQLTSDKAPSQSESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVAEDEDKEDEFGYS 1334

  Fly   851 AENIYFWTACERYRLLESEADRVAQAREIFAKH------LANNSS-----------DPVNVDSQA 898
            .:||.     |||..|..:...:    |:...|      ||.|..           ||.....:.
  Rat  1335 WKNIQ-----ERYGTLTGQLHMI----ELEKGHSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRD 1390

  Fly   899 RSLTEEKLADAAPDI------------------FAPAQKQIFSLMKFDSYQRFI-----RSDLYK 940
            ..|   ::||...:|                  .||::.:|..:...|:..:..     .:|...
  Rat  1391 GRL---QIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGSAADPLP 1452

  Fly   941 SCVEAEQKNQPLP-----YSGLDLDELLKTN-FHLG---------------------AFSKLKKS 978
            |..|:.|..:..|     .|.:||..|  || :||.                     ....|.:.
  Rat  1453 STSESPQNKEVEPSITTSASAVDLSSL--TNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTER 1515

  Fly   979 ASNAEDRRRK----------------------SLLPWHRKTRSKSRDRTEIMAD----------- 1010
            ...|:|.|.|                      |||    || :|:..:..:.|:           
  Rat  1516 GGAAKDGRLKPGDRILAVDDELVAGCPIEKFISLL----KT-AKTTVKLTVGAENPGCQAVPSAA 1575

  Fly  1011 -------MQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTE 1068
                   ...:..||.|.|...|:.|.|             .||..::.:.|..|          
  Rat  1576 VTASGERKDSSQTPAVPAPDLEPIPSTS-------------RSSTPAIFASDPAT---------- 1617

  Fly  1069 SVYSLCRVILTDGATTIVQTRPGET-------------VGELV-------------------ERL 1101
                 |.:|  .|..|.::...|:|             :|.::                   :::
  Rat  1618 -----CPII--PGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQI 1675

  Fly  1102 LEKRNLVYPYYDIVFQGSTKSIDV--QQPSQILAGKEVVIERRVAFK-LDLPDPKVISVKSKPKK 1163
            ||...:     |:......::|:|  |.|.::   :..:......:| .|:.|...:.::.:|.|
  Rat  1676 LEVNGI-----DLRKATHDEAINVLRQTPQRV---RLTLYRDEAPYKEEDVCDTFTVELQKRPGK 1732

  Fly  1164 QLHEVIRPILSKYNYKMEQVQVIMRDTQVPID--LNQPVTMADGQRL---RIVMVNSDFQVGGGS 1223
            .|.   ..|:.|.|           ||.|.:.  :...:..|||:.:   :|:|||.:       
  Rat  1733 GLG---LSIVGKRN-----------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGE------- 1776

  Fly  1224 SMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFER 1288
                            .:...|.:....||.........|..| :......|...||::|.:.| 
  Rat  1777 ----------------DVRNATQEAVAALLKCSLGTVTLEVGR-IKAAPFHSERRPSQSSQVSE- 1823

  Fly  1289 MRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEH 1353
                    .::.:..||   :....:|:.||.:|...|:|..                       
  Rat  1824 --------SSLSSFSLP---RSGIHTSESSESSAKKNALASE----------------------- 1854

  Fly  1354 QDELLEGLKRAQLAR-LEDQRGTEIN-------FDLPDF--LKNKENLSAAVSKLRKVRASLSPV 1408
                ::||:..::.: ..|..|..|.       .|:|.|  :.:...::|...|||..    ..:
  Rat  1855 ----IQGLRTVEIKKGPADALGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVG----DRI 1911

  Fly  1409 SKVPATPTEIPQPAPRLSITRSQQPVSPMK-------VDQEPETDLPAATQDQTEFAKA------ 1460
            ..:..|.|:        .:|.: |.|:.||       |......|:...|..|.|.|..      
  Rat  1912 VTICGTSTD--------GMTHT-QAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTG 1967

  Fly  1461 -------PPPL-PPKPKVLPIK--PSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFA 1511
                   |..| ||:.|.:.:.  |...|.: ..|.|   .||...:|...|.....|..|
  Rat  1968 LTSSTIFPDDLGPPQSKTITLDRGPDGLGFS-IVGGY---GSPHGDLPIYVKTVFAKGAAA 2024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 20/84 (24%)
PTB_RGS12 251..391 CDD:269984 29/168 (17%)
RGS_R12-like 828..941 CDD:188661 31/158 (20%)
RGS12_RBD 1073..1145 CDD:176412 14/105 (13%)
RBD 1144..1213 CDD:128731 16/74 (22%)
MpdzXP_006238402.1 L27_2 6..63 CDD:117611
PDZ_signaling 140..222 CDD:238492
PDZ_signaling 256..335 CDD:238492 349/1946 (18%)
PDZ 374..463 CDD:214570 20/92 (22%)
PDZ_signaling 552..621 CDD:238492 10/73 (14%)
PDZ_signaling 693..776 CDD:238492 18/108 (17%)
PDZ_signaling 993..1063 CDD:238492 11/69 (16%)
PDZ_signaling 1150..1241 CDD:238492 14/90 (16%)
PDZ 1348..1433 CDD:214570 14/91 (15%)
PDZ_signaling 1482..1561 CDD:238492 13/83 (16%)
MPDZ_u10 1563..1624 CDD:293272 14/90 (16%)
PDZ 1625..1709 CDD:214570 11/91 (12%)
PDZ_signaling 1721..1801 CDD:238492 19/116 (16%)
PDZ_signaling 1858..1943 CDD:238492 19/97 (20%)
PDZ_signaling 1984..2067 CDD:238492 11/45 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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