DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Grid2ip

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006248928.1	Gene:	Grid2ip / 288484	RGDID:	1310492	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	1573	Identity:	275/1573 - (17%)
Similarity:	431/1573 - (27%)	Gaps:	695/1573 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNGFGF 83
            |.|.|:||    |.....|.|...::...|.......|             |||.|.:|...|||
  Rat   233 VSTRASAA----PRRPDEPPPRKAASLLGGRTGPGGPR-------------RTVRVYKGNKSFGF 280

  Fly    84 TISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENY 148
            |:.|..|..:..::..||||.|.|:|||.::.:|||::....|:.||.::..|.....:.:.|..
  Rat   281 TLRGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGP 345

  Fly   149 YSDSSDEENAHATLR----------GQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPE---- 199
            ...:||.::..:..|          ..:|.:|:|.:.|..  ..:|..|       |.|||
  Rat   346 VPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTF--SQQLDHL-------LTPPERYGV 401

  Fly   200 --AVEPHKSKSSPDHPTL----KPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYL 258
              |:|......|.|  ||    .|||:.|
  Rat   402 CRALESFFQHRSID--TLIVDVYPVLDTP------------------------------------ 428

  Fly   259 GTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFV 323
                 .||:......|.:....::|.|||      :.|..          |....|...:.|:..
  Rat   429 -----AKQVLWQFLYQLLTYEEQELCQEK------IACFL----------GYTAITEPESSLDLE 472

  Fly   324 SSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRA 388
            ..|:.                  |...||...|:..|     |..|...:       .:|.|
  Rat   473 PESTP------------------EPTPEPQPRSSLRA-----SSMCRRSL-------RSQGL--- 504

  Fly   389 HEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAA 453
             |..|.|....    |.|.|               :.::|              |...||...:.
  Rat   505 -EASLSCGPGD----CSEMP---------------LPLIP--------------GERQAGDGTSL 535

  Fly   454 AHSPQPSNHSEI-STTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPAR 517
            ..:|.|...|.: :...|..:||                   .....|..:.:.|.||.
  Rat   536 PETPNPKMMSAVYAELESRLNSG-------------------FKGKIGTVSKSRASPPV------ 575

  Fly   518 PLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLF 582
                                               |:|:.:
  Rat   576 -----------------------------------PSLVGT------------------------ 581

  Fly   583 VDDSPRTLAAVASMDDISLHS-----------AAPSLDEGHTFAHPACVPRKMRRSLALETPTTP 636
              ..||||:.|:...|..|.|           |:||..|.|.:|             :|::...|
  Rat   582 --SGPRTLSGVSWPGDRLLPSPCYDPLCSGGLASPSSSESHPYA-------------SLDSSRAP 631

  Fly   637 HKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHC 701
            ..       |||                               |.::|
  Rat   632 SP-------QPG-------------------------------LGSIH----------------- 641

  Fly   702 LLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDND 766
                    ||     .|.:..|.|          |.|     .::....|.|||      :.|.|
  Rat   642 --------PD-----SPPSPDPIR----------PPS-----RRKLFAFSRPVR------SRDTD 672

  Fly   767 MYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERM 831
            .::..|           ..||.    |:|...
  Rat   673 RFLDVL-----------SEQLG----PRVTIV--------------------------------- 689

  Fly   832 LQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDS 896
                      .:||..|...|.:.|.         :.:...|...|        :::|:.|:...
  Rat   690 ----------DDFLTPENDYEEMSFH---------DDQGSFVTNER--------SSASECVSSSE 727

  Fly   897 QARSLTEEKLAD--AAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDL 959
            :..|||...::|  ..|.:..|..                               .|||:..
  Rat   728 EGSSLTYSSISDHIPPPPLSPPPP-------------------------------PPLPFHD--- 758

  Fly   960 DELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQN 1024
                            .|.:|...|           ..|...:..|:.:..:.|.:.|.||.|..
  Rat   759 ----------------PKPSSRTSD-----------GPRGPPQSLTKPLTQISHPVPPPPPPPLP 796

  Fly  1025 APLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTR 1089
            .|:..|...:..|.                       |...|..|..|:.|:....     |:..
  Rat   797 PPVPCAPPMISRGV-----------------------GHRRSETSHMSVKRLRWEQ-----VENS 833

  Fly  1090 PGETVGELVERL-LEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDP- 1152
            .|...|:|.|.. .:|.:.:..|.|:.....|     |:|.:.:.|               |:|
  Rat   834 EGTIWGQLGEDSDYDKLSDMVKYLDLELHFGT-----QKPPKPVPG---------------PEPF 878

  Fly  1153 ---KVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVN 1214
               :|:.:.|..|            .||..:               |...:.:..|:..:::|
  Rat   879 RKKEVVEILSHKK------------AYNTSI---------------LLAHLKLTPGELRQVLM-- 914

  Fly  1215 SDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAP 1279
                     ||.|::.:|      .||.:|.      |.|..||    |:.|     .....|||
  Rat   915 ---------SMEPRRLEP------AHLAQLL------LFAPDAD----EEQR-----YQAFREAP 949

  Fly  1280 SETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLK-AGVK 1343
            .         |..:.|...:....:|:.|.:..|...|    ||.|...:..:..:..|: |.::
  Rat   950 G---------RLSEPDQFVLQMLSVPEYKTRLRSLHFQ----ATLQEKTEEIRGSLECLRQASLE 1001

  Fly  1344 LQVTERVAEHQDELL---EGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRKVRASL 1405
            |:.:.::|:..:.:|   ..|...| .:.....|.:||| |.: |.:.:.:....:.|..:..||
  Rat  1002 LKNSRKLAKILEFVLAMGNYLNDGQ-PKTNKTTGFKINF-LTE-LNSTKTVDGKSTFLHILAKSL 1063

  Fly  1406 SPVSKVPATPTEIPQPAPRLSITRSQQPVSPM--KVDQEPET-DLPAATQDQTEFAKAPPPLPPK 1467
            |             |..|.|.......|..|:  ||:|...| ||.......:|...|
  Rat  1064 S-------------QHFPELLGFAQDLPTVPLAAKVNQRALTVDLADLHDTVSEIQVA------- 1108

  Fly  1468 PKVLPIKPSNWGVAQPTGNYCNKYSPSKQ-----VPTSPKEASKPGTFASKIPLD-LGRKSLEEA 1526
                                |....||.:     |.||..|.::|...|    || |.|:::||.
  Rat  1109 --------------------CQSMVPSSEDRFAVVMTSFLETAQPALRA----LDGLQREAMEEL 1149

  Fly  1527 GSRCAYLDEPSSS 1539
            |...|:..|.|.:
  Rat  1150 GKALAFFGEDSKA 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	27/75 (36%)
		PTB_RGS12	251..391	CDD:269984	21/139 (15%)
		RGS_R12-like	828..941	CDD:188661	15/114 (13%)
		RGS12_RBD	1073..1145	CDD:176412	13/72 (18%)
		RBD	1144..1213	CDD:128731	9/72 (13%)
Grid2ip	XP_006248928.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		PDZ_signaling	269..342	CDD:238492	25/72 (35%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	26/136 (19%)
		FH2	812..1180	CDD:280362	100/495 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900