DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and WHRN

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_011516787.1 Gene:WHRN / 25861 HGNCID:16361 Length:918 Species:Homo sapiens


Alignment Length:846 Identity:169/846 - (19%)
Similarity:284/846 - (33%) Gaps:237/846 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 IRTVEVRR--GYNGFGFTISGQQPCRLSCIIS----SSPAEQAGLRSGDFLISVNGLNVSKLPHE 127
            :|.|.:||  .:.|.||:|.|.....:...:|    .|.||:.|||.||.::.||..:::::.|.
Human   138 VRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHA 202

  Fly   128 TVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQ 192
            ..|:.:..|     .::..:.||            .|::....:.:         .::...:...
Human   203 EAVKALKGS-----KKLVLSVYS------------AGRIPGGYVTN---------HIYTWVDPQG 241

  Fly   193 KKLNPPEAV-EPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVG 256
            :.::||..: :||..       .|:....|...|.:|.:..|...|:.::....|..|..|....
Human   242 RSISPPSGLPQPHGG-------ALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAE 299

  Fly   257 Y-LG---TIEMPKQISHSSKLQ--------TVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSG 309
            | ||   |...|...:..|.|:        ..||.:..|..|..:             .|:||..
Human   300 YGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVR-------------LLKSSRH 351

  Fly   310 GVLATYSSARL----------NFVSSSSESENR-----FFG-LVTSAVHNTQIEEEYEPSAGSAA 358
            .:|......||          .:::||...|..     |.| |.|..::....   |:..|||..
Human   352 LILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGF---YKGPAGSQV 413

  Fly   359 AAGHISISHSCHVFVIDTKLIEHAQHLQRAHE-------------------------FRLQCTRD 398
            ...  |:.:...|.     |.|.|:||....|                         |:|..|..
Human   414 TLS--SLGNQTRVL-----LEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHA 471

  Fly   399 PISNLCLEF-----PNNSEYVVNLV--RSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHS 456
            ..| |..|.     |.:.|...:||  |.:.:|:...|          .|.||.           
Human   472 KFS-LLSEVRGTISPQDLERFDHLVLRREIESMKARQP----------PGPGAG----------- 514

  Fly   457 PQPSNHSEISTTTSNSDSGI-GFNNDCTNISDRIL--------VVDFLAAGAGAAAAAHAGPPTY 512
               ..:|.:|.:.:.|.:|. |.:...::..:|:|        .:|....|.......:|.|.  
Human   515 ---DTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEETGEAVQGNINALPD-- 574

  Fly   513 PAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSS----LRRPNLLASFNLIQSPATNLTSTR 573
                     |.:.|.|.|.:.:.....|.|.||.:..    |.:|..|...:| |.|    :|..
Human   575 ---------VSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGREDL-QPP----SSMP 625

  Fly   574 SCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHK 638
            ||...    |..:|:..:..|........|:|..|.....:|           |::...|::...
Human   626 SCSGT----VFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYA-----------SVSPANPSSKRP 675

  Fly   639 LSAQVFGQPGSRHSLG-FEAID--------SVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMS 694
            |.|.:  ...::|.:| |..:.        |.:::|:|.|:         |......|.|:|   
Human   676 LDAHL--ALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCL---------LPPSPSGHPDQT--- 726

  Fly   695 ASSSSHCLL---EATNSEPDLGN-RALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVR 755
             .::.|.::   ...:||||:.. ||||...:....:....|.:|...|. ..:..:...|:|.|
Human   727 -GTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDS-GVDAGEAEASAPGR 789

  Fly   756 RTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTP------APPSAITASVAAEGA 814
            ...|::....          |..:..|::........|..|..|      ...||.|..:|.||.
Human   790 GRQSVSTKSR----------SSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGG 844

  Fly   815 A 815
            |
Human   845 A 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 23/81 (28%)
PTB_RGS12 251..391 CDD:269984 37/192 (19%)
RGS_R12-like 828..941 CDD:188661
RGS12_RBD 1073..1145 CDD:176412
RBD 1144..1213 CDD:128731
WHRNXP_011516787.1 HN_L-whirlin_R1_like 37..112 CDD:259822
PDZ_signaling 138..215 CDD:238492 23/81 (28%)
PDZ_signaling 277..357 CDD:238492 19/92 (21%)
HN_L-whirlin_R2_like 419..499 CDD:259823 17/85 (20%)
PDZ_signaling 827..898 CDD:238492 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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