DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and rgs1

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_593029.1	Gene:	rgs1 / 2541764	PomBaseID:	SPAC22F3.12c	Length:	481	Species:	Schizosaccharomyces pombe

Alignment Length:	333	Identity:	69/333 - (20%)
Similarity:	118/333 - (35%)	Gaps:	100/333 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 SSSHCLLEATNSEPDLGNRALPAN-----ASPFRRAWGQSS------FRTPRSDKVAKEQ----- 745
            |:..|||:.|.....:.:..|..|     |..:...|..|:      .|...:|::.|:.
pombe   146 SNEKCLLQLTRKGYSVVSEFLQHNGHNSQAELYASKWNHSAPVIVSISRFSSTDQILKDSSFCEM 210

  Fly   746 ---------QQLGQSS-----PVRRTASMNASDN-------DMY---------IKTLMLD-SDLK 779
                     .::|:|.     ||...:|.:..|:       .|:         ..|::|| |:::
pombe   211 LLVRMLGSVHEIGKSKNPLLVPVYSVSSPSPKDSLSKVTKYQMFGIDIAEWLMCNTMLLDWSEME 275

  Fly   780 SSRSQHQL-SLLQVPKVLTTPAPPS---AITASVAAEGAAQDHGCPSSWA--------------- 825
            :..|...: |.:.......||...|   .::..:..:|.|     ...|.
pombe   276 TVASDLLIHSYIAYENNSETPLKFSYAKGVSYFLTGKGIA-----TLGWTKNVSNNKLINKINEV 335

  Fly   826 --GSFERMLQDA----AGMQT-FSEFLKKEFSAENIYFWT-ACE--RYRLLESEADRVAQAREIF 880
              ||..:.:.:.    ..:|| |.|||||.|..||..|:: .||  .|....:|.:.....||.|
pombe   336 EKGSTNKEILETILRKPNLQTYFFEFLKKNFCDENQRFYSEVCEFNDYFSHANETNDHEAIRESF 400

  Fly   881 AK-------HLANNSSDPVNVDS---------QARSLTEEKLAD---AAPDIFAPAQKQIFSLMK 926
            |.       .|::|:.:.||:.|         .|.::..|.|.:   ....:...||..:..||.
pombe   401 AHACGIYNCFLSSNAPNAVNLPSDLYEKITNHMALAMEVEPLNEWLQLIHILLLEAQTAVLDLMA 465

  Fly   927 FDSYQRFI 934
            .||..:|:
pombe   466 GDSLLKFL 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	35/134 (26%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
rgs1	NP_593029.1	DEP	59..156	CDD:214489	4/9 (44%)
		DEP_RGS7-like	224..309	CDD:239897	15/84 (18%)
		RGS_FLBA	344..480	CDD:188663	35/130 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006108
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16841
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930