DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and X11L

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	1137	Identity:	204/1137 - (17%)
Similarity:	377/1137 - (33%)	Gaps:	318/1137 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 SNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQAD--------YEAGAGAAAAGGAVAAAHSP 457
            ||.|.:..|.|......::..:..:.....|..||..        :|....:.....|....:||
  Fly     3 SNSCSDSSNESMVNPPHIQMNFGQQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNSP 67

  Fly   458 QPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAP-ARPLGI 521
            ..:...........|.||.|...               :...|:.|...:|...|..| ...:.:
  Fly    68 DLNGELSYVPLQGLSPSGGGVQG---------------SGSYGSNAGRDSGSYYYQRPQLHQIRL 117

  Fly   522 VGIPDNRLTVR-AMPDHSALLRSP----PASSSLRRPNLLASFNLIQSPATNLTST----RSCDD 577
            ...|.::...| .:|...|...||    .|.....|...:..|:.|.:...|..|:    .|.:|
  Fly   118 GRSPGSQFETRDVLPQGLASPGSPTDVGKADGQCLRDGEIVVFDDIDTNWMNKASSGQRPGSNED 182

  Fly   578 VLNLF----------VDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALET 632
            ||.:.          .:.|||...:..:.:.|::         |.....|...|:::       :
  Fly   183 VLKVTKMIGQLPIAEYEGSPRRFGSQPNTNTITM---------GGPRKRPPGFPQRV-------S 231

  Fly   633 PTTPHKLSAQVFGQPGSRHSLGFEAIDSV--QSSVSGACMDQT---------MDTWASLQNLHKS 686
            |||....:|..    .::.|:| ..||.|  :...||...::|         .:|...|:...|:
  Fly   232 PTTSVANNATA----AAKASVG-NLIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKA 291

  Fly   687 H----KDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAW-GQSSFRTPRSDKVAKEQQ 746
            :    |..|..:..|..    :..:|:|    :..|  |:|..:|: ||...|.|      |::.
  Fly   292 NPEDEKRYTDYTTESGD----DVASSQP----QEYP--ATPMEQAYIGQRLARIP------KDEL 340

  Fly   747 QLGQSSPVRR--------TASMNASDNDMYIKTL------MLDSDLKSSRSQHQLSLLQVPKVLT 797
            .:...||.::        ||....:|.::||.:.      :.|::|:::..:|..:....|:...
  Fly   341 YMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTD 405

  Fly   798 TPAPPSAITASVAAEGAAQDHGCPSSWAGSFERM--LQDAAGMQTFSEFLKKEFSAENIYFWTAC 860
            ..:....:      :..:.|..||:.:...:..|  |:|.......|:      :..|:.  ..|
  Fly   406 YDSNCGDL------DSLSNDINCPTDFGKLYTSMPVLEDGLSSGHASD------TENNVS--VVC 456

  Fly   861 ERYRLLESE--------ADRVAQAREIFAKHLANNSSD-------------PVNVDSQARSLTEE 904
            ::.:..:|:        .:|:.....:.:..||..::|             |:.......|..:.
  Fly   457 DKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSPPQI 521

  Fly   905 KLADAA------PDIFAP----------------------------------------AQKQIFS 923
            ::|||:      ||...|                                        |..:|..
  Fly   522 EIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQE 586

  Fly   924 LMKFDSYQRFIRSDLYKSCVEAEQKNQP--LPYSGLDLDELLKTNFHLGAF-----SKLKKSASN 981
            .||      .|||.|.::      |.||  |.:    .||:|.|:.....:     :.:..:...
  Fly   587 AMK------EIRSALQRA------KTQPEKLKF----CDEVLPTDPDSPVWVPRKGTTISTAQGA 635

  Fly   982 AEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHA---LMPAPPVPQNAPLTSASLKLVCGQNSLSD 1043
            |.|....:.|...|....:..|..:..||...|   ......:..|..|...|     ..|:.:.
  Fly   636 AADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTS-----DNNNPNP 695

  Fly  1044 LHSSRSSLSSFDAGTATGGQGAS-TESVYSLCRVILTDGATTIVQTRPGE------TVGEL---- 1097
            :::|:.  .::...|...|.|.| |.:...:|:::   |.|.|..:.|.:      ..|.:
  Fly   696 MNNSKP--QTYSTATIRQGIGTSLTPNSPDICQIV---GTTDISISSPEKLQFTKSPTGSIKSLK 755

  Fly  1098 -------------VERLLEKRNLVYPYYDIVFQ----GSTKSIDVQQP---SQILAGKEVVIERR 1142
                         .|.|||.:.|:   ..::|:    |||:.:...||   ::::..:|.|..
  Fly   756 DSANSDKKAKSRNKEGLLEPKVLI---EGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSR-- 815

  Fly  1143 VAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRD-TQVPID--LNQPVTMAD 1204
              .|...|:.     :|:|..::...|         ..|::.|:..| .::.:|  |.....:||
  Fly   816 --IKALAPEG-----ESQPSTEVDLFI---------STEKIMVLNTDLKEIMMDHALRTISYIAD 864

  Fly  1205 GQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVD 1269
            ...|.::|....|.  ..|.:.|..:.|:..:|...:.|                   |:|.|.:
  Fly   865 IGDLVVLMARRRFV--PNSVVDPSITSPLGDVPTPGIGE-------------------EESPPKE 908

  Fly  1270 LCSMKSNEAPSETSSLFERMRRQ---QRDGGNIPASKLPKLK-----KKSTSSSQQSEEAATTQA 1326
            ..| |.|..|.....:||....|   |..|.....:.:..||     .:|.:.....:|...:|.
  Fly   909 PLS-KHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQE 972

  Fly  1327 VADPKKPIIAKLKAGVKLQVTERVAEHQDELL 1358
            :...:..|.||    .:||....|.:.:.|:|
  Fly   973 IFGDELEIFAK----KELQKEVVVPKAKGEIL 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	27/181 (15%)
		RGS12_RBD	1073..1145	CDD:176412	19/101 (19%)
		RBD	1144..1213	CDD:128731	13/71 (18%)
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	43/221 (19%)
		PDZ_signaling	988..1065	CDD:238492	3/13 (23%)
		PDZ_signaling	1092..1151	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900