DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and PDZD2

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_005248326.1 Gene:PDZD2 / 23037 HGNCID:18486 Length:2873 Species:Homo sapiens


Alignment Length:2064 Identity:401/2064 - (19%)
Similarity:639/2064 - (30%) Gaps:739/2064 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 TAVGTGAAAAEDASPAAN-SGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNG 80
            |...|....:..|||..| ||.|  |...:..||:|...::....:...........|.|.|. |
Human   679 TPCSTPTHMSRSASPNFNTSGGA--SAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGL-G 740

  Fly    81 FGFTISGQQPCRLSC--------IISSSPAEQAGLRS----GDFLISVNGLNV------------ 121
            .|       .|.|:.        |.|.:|...|.:.|    ||.::.||.:||            
Human   741 IG-------ACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798

  Fly   122 SKLPHETVVQLIGN------SFGSIRMQIAENYYSDSSD-------------------------- 154
            ||.|...|..:||.      |...:...||.:.|.:|.:                          
Human   799 SKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISES 863

  Fly   155 ----------------------EENAH------ATLRGQLLAASLRH----KPRF---------- 177
                                  |:..|      .:..|.|..::..|    |||.          
Human   864 ELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHR 928

  Fly   178 ---LHHK----AKLHRLRNSPQKKLNP---PEAVEPHKSKSSPDHP-----------------TL 215
               |.||    |:...|..|||...||   ...|..:.:..:.|..                 .:
Human   929 ASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCISLPGALPGPI 993

  Fly   216 KPVLEDPP--LTANLSKAADVAN---------VSAMVRA--VGSAA-LECRVIVGYL-------- 258
            :|:.||.|  ::.:.||..||.|         ||..:.|  :||:. ||..:..|.:        
Human   994 RPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAAN 1058

  Fly   259 --GTIEMP---------KQISHSS---KLQ-TVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSS 308
              .:.|.|         |::|.||   ||: |||:       :.:.||     .|....|.|..|
Human  1059 LTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRT-------DTQSPT-----NTGSPSSPQQKS 1111

  Fly   309 GGVLATYSS-ARLNFVSSSSESENRFFGLVT--------------SAVHNTQIE---EEYEPSAG 355
            .|:.:.:.. ||::.....||:|.:..|..|              |.|..|.::   ..::|  |
Human  1112 EGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQP--G 1174

  Fly   356 SAA--------AAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSE 412
            .|.        ..|...:|.||       :|.....||..:|                       
Human  1175 GAVEKESLGKLTTGDACVSTSC-------ELASALSHLDASH----------------------- 1209

  Fly   413 YVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIG 477
            ...||.::...:...|      ..:.::.:...::.|...||| |.||..|..:...|..:    
Human  1210 LTENLPKAASELGQQP------MTELDSSSDLISSPGKKGAAH-PDPSKTSVDTGQVSRPE---- 1263

  Fly   478 FNNDCTNISDRIL------VVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRA--- 533
              |.....|.|:.      .|.....|:.:.....|.||.| :..|.......|.|...|.|   
Human  1264 --NPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDY-SKTRSASETSTPHNTRRVAALRG 1325

  Fly   534 -------MPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLT---STRSCDDVLNLFVDDSPR 588
                   |....|:|...|.:|..:|.....:    .|.|..:|   :..|..:...|...||..
Human  1326 AGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGN----HSKALEMTGIHAPESSQEPSLLEGADSVS 1386

  Fly   589 TLAAVASMDDISLHSAAPSLDE-----GHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPG 648
            :.|..||:      |..||.|.     ||...|  |.|...|.|...:..:...:|.|.....|.
Human  1387 SRAPQASL------SMLPSTDNTKEACGHVSGH--CCPGGSRESPVTDIDSFIKELDASAARSPS 1443

  Fly   649 SR----------------------HSLGFEAIDSVQSS------VSGACMDQTMDTWAS------ 679
            |:                      .|...|.:...|:|      .:||   .....|||      
Human  1444 SQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGA---PAYPQWASQPSVLD 1505

  Fly   680 ------------------LQNLHKSHKDRTSMS--------ASSSSHCLLEATNSEPDLGNRALP 718
                              .:|....|:|.||:|        :.||.:...|.::|:|:....|..
Human  1506 SINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPR 1570

  Fly   719 ANASPFRRAWG--QSSFRTPRSDKVAKEQQQL--------------------------------- 748
            |:|   |..|.  :|.....:.|....|::|:                                 
Human  1571 ASA---RDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLS 1632

  Fly   749 --------GQSSPVRRTASMNAS-----DNDMYIKTLMLDS-------DLKSSRSQHQLSLLQVP 793
                    ..:||..:.|.:..|     |:......|.:.|       |:.:|:: |:.|..:..
Human  1633 LKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQN-HRPSCAEET 1696

  Fly   794 KVLTTPAPPSAITASVAAEGAAQDHGCP------------------SSWAGSFERMLQDAAGMQT 840
            ..:|:.:  ||:..|..::.|...|..|                  ......:|..:..||.:.:
Human  1697 TEVTSAS--SAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSS 1759

  Fly   841 FSEFLKK--EFSAENIYFWTACERYRLLESEADRVAQAREIFA------KHLANNSSDPVNVDSQ 897
            ||..:.|  |...||::...:.:...||:.  .::...|.|.|      ||         |..:.
Human  1760 FSVDVPKNGESVLENLHISESQDLDDLLQK--PKMIARRPIMAWFKEINKH---------NQGTH 1813

  Fly   898 ARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYS------- 955
            .||.||::      ....||:..       ||..:.:.|        :::|...:|:|       
Human  1814 LRSKTEKE------QPLMPARSP-------DSKIQMVSS--------SQKKGVTVPHSPPQPKTN 1857

  Fly   956 --GLDLD-----ELLKTNFHLGAFS-KLKK-------------SASNA-----EDRRRKSLLP-W 993
              ..||.     |:|.||....... |||:             .|:||     .|.|:..:.| .
Human  1858 LENKDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQT 1922

  Fly   994 HRKTRSKS--------------RDRTEIMADMQHALMPAPPVPQNAPL------TS--------A 1030
            ..||.||:              |:.|......|..|...||:..:.||      ||        .
Human  1923 SHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLT 1987

  Fly  1031 SLKLVCGQNSLSDLHSSRSSLSSFDAG-------------------------TATGGQGAST--- 1067
            |.|.|..|...|..|  .:.||..|.|                         .|....|.|.   
Human  1988 SPKPVPEQGMWSRFH--MAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGN 2050

  Fly  1068 -ESVYSLCRVILTDGATTIVQTRP-GETVGELV--ERLLEKRNLVYPYYDIVFQGSTKSIDVQQP 1128
             :|...|...:..|.|    |.|| ||..|.::  :| ||:.|.: ...:|..:..::::...:|
Human  2051 RQSEPRLASHVAADTA----QPRPTGEKGGNIMASDR-LERTNQL-KIVEISAEAVSETVCGNKP 2109

  Fly  1129 SQ-------ILAG-----KEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKME 1181
            ::       :..|     .|:.:.|:||          .|..|.|..         |..:..:.|
Human  2110 AESDRRGGCLAQGNCQEKSEIRLYRQVA----------ESSTSHPSS---------LPSHASQAE 2155

  Fly  1182 QVQVIMRDTQVPIDLNQPVTMA----DGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLD 1242
            |            ::::..:||    ....|:..:..:::..|..|.|...:..|...:|.|...
Human  2156 Q------------EMSRSFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSG 2208

  Fly  1243 ELTNKVFNELLASKADAAASEKSR--------PVDLCSMKSNEAPSETSSLFERMRRQQRDGG-- 1297
            | .:..|....|::..:..::.|.        |..|...:.::.| .|||:....:..:  ||  
Human  2209 E-DHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLGRSRDSQVP-VTSSVVPEAKASR--GGLP 2269

  Fly  1298 -------------------NIPASK--------------LPKLK-------------KKSTSSSQ 1316
                               |:||:.              ..|:|             .:|||...
Human  2270 SLANGQGIYSVKPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFS 2334

  Fly  1317 QSEEAATTQAVADPKKPIIAKLKAGVKLQVTER--------------VAEHQDELLEGLKRAQLA 1367
            ..:...:.:.:|:..:| :||..|...|.|:.:              ...|..:....|.|..|:
Human  2335 VKQRIKSFENLANADRP-VAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLS 2398

  Fly  1368 RLEDQRGTEINFDLPDFLKNKENLSAAVSKLR-----------KVRASLSPVSKVPATPTEIPQP 1421
            ...:.: :|....||...|:...::..:|:..           :::.||.|:. :|.....:..|
Human  2399 SCSENQ-SEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLG-IPTPTMTLASP 2461

  Fly  1422 APR--LSITRSQ-QPVSPMKVDQ-----EPETDL---------PAATQDQTEFAKAP--PPLPPK 1467
            ..|  .|:..:| .|||..|:.:     .|:.|.         |:|...:||....|  .|.||.
Human  2462 VKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPA 2526

  Fly  1468 PKV-LPIKPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKIP 1515
            ..| .|.|..|  .|.|.|:     .|......:|..||..|..|..:|
Human  2527 GGVSCPEKGGN--RACPGGS-----GPKTSAAETPSSASDTGEAAQDLP 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 25/105 (24%)
PTB_RGS12 251..391 CDD:269984 40/188 (21%)
RGS_R12-like 828..941 CDD:188661 26/120 (22%)
RGS12_RBD 1073..1145 CDD:176412 19/86 (22%)
RBD 1144..1213 CDD:128731 10/72 (14%)
PDZD2XP_005248326.1 PDZ_signaling 335..416 CDD:238492
PDZ_signaling 589..670 CDD:238492
PDZ_signaling 726..810 CDD:238492 22/91 (24%)
PDZ_signaling 2623..2694 CDD:238492
PDZ 2785..2867 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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