DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and Cytip

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_631939.1	Gene:	Cytip / 227929	MGIID:	2183535	Length:	359	Species:	Mus musculus

Alignment Length:	366	Identity:	77/366 - (21%)
Similarity:	139/366 - (37%)	Gaps:	83/366 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ASGSTAVGTGAAAAED---ASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIRTVEV 74
            |.||.:|.||....||   ....|:      :.:|.|.| ..|....|.....:::::..:.|.|
Mouse    23 AYGSYSVLTGQLTMEDNRRIQVLAD------TVATLPRG-RKQLALARSSSLGDFSWSQRKVVTV 80

  Fly    75 RRGYNG-FGF----------TISGQQPCRLSC-IISSSPAEQAGLRSGDFLISVNGLNVSKLPHE 127
            .:..|| |||          .|...:.|.:.| :...|||..|||:.||...:|||::.....|:
Mouse    81 EKQDNGTFGFEIQTYRLQNQNICSSEVCTMICKVQEDSPAHCAGLQVGDIFANVNGVSTEGFTHK 145

  Fly   128 TVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQ 192
            .||.||.:|...:.::                 ||.|.::     |:...|  :|||..|:.:.:
Mouse   146 QVVDLIRSSGNLLTIE-----------------TLNGTMI-----HRRAEL--EAKLQTLKQTLK 186

  Fly   193 KKLNPPEAVEPHKSK----SSPDHPTLKPV-LEDPPLTANLSKAADVANVSAMVRAVGSAALECR 252
            ||.....::...:.:    .:.:.|.|:.: |::..|..||...:.    :.:.|...|:...|:
Mouse   187 KKWVELRSLHLQEQRLLHGDTANSPNLENMDLDESSLFGNLLGPSP----ALLDRHRLSSESSCK 247

  Fly   253 VIVGYLGTIEMPKQISHSSKL--QTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATY 315
               .:|.::.:..:..:.|.:  .::|...      .||       .:.|.....|..|..:...
Mouse   248 ---SWLSSLTVDSEDGYRSSMSEDSIRGAF------SRQ-------TSTDDECFHSKDGDEILRN 296

  Fly   316 SSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGS 356
            :|:|          .||...:.:|...:...|..|....|:
Mouse   297 ASSR----------RNRSISVTSSGSFSPLWESNYSSVFGT 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	27/87 (31%)
		PTB_RGS12	251..391	CDD:269984	17/108 (16%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Cytip	NP_631939.1	PDZ_signaling	76..161	CDD:238492	27/84 (32%)
Cytip	NP_631939.1	Interaction with CYTH1. /evidence=ECO:0000250	166..188		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810