DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and LNX2

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_699202.1	Gene:	LNX2 / 222484	HGNCID:	20421	Length:	690	Species:	Homo sapiens

Alignment Length:	171	Identity:	41/171 - (23%)
Similarity:	67/171 - (39%)	Gaps:	47/171 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPITGASGSTAVGTGAAAA---------------EDASPAANSGPAPIS-----TSTTPS----- 47
            :.:|..|.|.||....|:|               |:|:..|...|:..|     .|.:||
Human   525 IDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWL 589

  Fly    48 GSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNG-FGFTISG-------QQPCRLSCIISSSPAEQ 104
            |..|..|             ....:.:||.|.| :||:|.|       .||..:..|:..:||..
Human   590 GLPSTLH-------------SCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641

  Fly   105 AG-LRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQI 144
            .| |:.||.:::||||:...:.|..:|.::......:.:.:
Human   642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	23/85 (27%)
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
LNX2	NP_699202.1	mRING-HC-C3HC3D_LNX2	45..89	CDD:319694
		modified RING-HC finger (C3HC3D-type)	50..87	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..224
		NPXY motif	208..211
		PDZ	230..316	CDD:214570
		PDZ	336..422	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..455
		PDZ_signaling	466..542	CDD:238492	5/16 (31%)
		PDZ_signaling	599..683	CDD:238492	23/84 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900