DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and rgs-10

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_510482.1	Gene:	rgs-10 / 185764	WormBaseID:	WBGene00004353	Length:	270	Species:	Caenorhabditis elegans

Alignment Length:	377	Identity:	70/377 - (18%)
Similarity:	123/377 - (32%)	Gaps:	117/377 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   627 SLALETP-TTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDR 690
            |||:.:| ....||.::|.|:...:    .:..||:...|:..|:.|     .|.::.|..
Worm     2 SLAVFSPCDVASKLLSEVVGEKYPK----VDDDDSIVEPVTSLCLPQ-----LSYEDFHHF---- 53

  Fly   691 TSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVR 755
                             |...|.|:..|...:   ..|...:    :.|...|::..|.....|.
Worm    54 -----------------SVIPLWNKTFPCRLA---TEWNPKN----KKDAPPKKKNALVILERVA 94

  Fly   756 RTASMNASDNDMYIKT----LMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQ 816
            ..::.||....:.|..    ||..|..:...|:......:.|:.|                 ||.
Worm    95 SRSNQNAVSRVINILRSKVHLMFSSSNELPSSEDVERWKKSPETL-----------------AAS 142

  Fly   817 DHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFA 881
            ::||                  ..|.:|||::.|...:.||..|:::| ....:.|..:||.||.
Worm   143 EYGC------------------NLFIQFLKEQTSENEVDFWLDCQKFR-SSKMSSRQNEARRIFD 188

  Fly   882 KHLANNSSDPVNVDSQARSLTEEKLAD--AAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVE 944
            ::.|..|...:.::.....:.:..|.:  .....|..||..:...:...|:::|:...||
Worm   189 EYFAMGSPKKIYIERYLWCVVQAYLVNDPGWRHTFDVAQAYVGLKLAKKSHKKFLEDPLY----- 248

  Fly   945 AEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRK 996
                        |||.||:.:..:...|                    ||.|
Worm   249 ------------LDLVELVTSGVNYNKF--------------------WHDK 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	24/114 (21%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
rgs-10	NP_510482.1	RGS	135..251	CDD:279009	31/168 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810