DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and F28E10.4

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_500590.2	Gene:	F28E10.4 / 185067	WormBaseID:	WBGene00017902	Length:	324	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	74/411 - (18%)
Similarity:	137/411 - (33%)	Gaps:	129/411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 VAQAREIFAKHLANN---SSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFI 934
            |.|.|.:|:..|:|:   .:|.|.::.                               |....:|
Worm    16 VGQVRVVFSFKLSNHDIGKTDAVKIED-------------------------------DMTVSYI 49

  Fly   935 RSDLYKSCVEAEQKNQPLPYSGLDL-DELLKTNFHLGAFSK-----LKKSASNAEDRRRKSLLPW 993
            .|:.:              ::||.: |::::.|...|:.|:     |:.:|.|.|..|||.:.|.
Worm    50 CSNSF--------------FNGLIMGDKIIRVNNVSGSASRCQSELLRGTACNVEVSRRKGVTPV 100

  Fly   994 HRKTRSKS-----RDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSSLSS 1053
            ..:..:||     :.....:.|::.        |.:...||..|||        .:...|:.::.
Worm   101 TCERLAKSGCNLRKGHACFVLDVER--------PPHMTTTSVGLKL--------GIIKRRAFVTK 149

  Fly  1054 FDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQG 1118
            .|..|.........:|:..:      .||...:...|...:.|.:.||              ..|
Worm   150 VDPNTIASSFFGCGDSIMDM------SGAPIPMTDNPDNFIREHLSRL--------------STG 194

  Fly  1119 STKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQV 1183
            :..|..|::|..:...|:.   ::....:...|.:|            |:.:.::..........
Worm   195 AKVSFLVERPISVAMAKQY---QKFIESITYDDSEV------------EMAQDVIEIGREASNMH 244

  Fly  1184 QVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKV 1248
            .:|::....|..|:..|      |.|....|...:...||......|..||         :|:.|
Worm   245 FMILKKLVTPSILSSDV------RRRKKSNNKTSESTEGSITISSASTEMK---------ITSDV 294

  Fly  1249 --FNEL--LASKADAAASEKS 1265
              |::|  :.||:.||.|..|
Worm   295 TDFDDLKPVESKSHAAGSSSS 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	11/70 (16%)
		RGS12_RBD	1073..1145	CDD:176412	11/71 (15%)
		RBD	1144..1213	CDD:128731	9/68 (13%)
F28E10.4	NP_500590.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900