DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and rgs-6

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001294820.1	Gene:	rgs-6 / 180840	WormBaseID:	WBGene00004349	Length:	734	Species:	Caenorhabditis elegans

Alignment Length:	790	Identity:	165/790 - (20%)
Similarity:	298/790 - (37%)	Gaps:	218/790 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 PKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGS------FERMLQDAAGMQTFSEFLKKEFSA 851
            |...|..:|.:..:.|..:.|.    |..|:...|      |:::::|......|.|||:::|.|
Worm    10 PATPTNTSPNNETSNSCLSMGV----GVASNETNSSRELKIFKKVIRDPVLRAPFQEFLEQQFCA 70

  Fly   852 ENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVD-SQARSLTEEKLADAAP-DIF 914
            ||:.|:.|.|:::.::...:|.:..|.||.::.|.||::|||:| |.::.:.|...:...| |.:
Worm    71 ENLNFYLAVEQFKEIQDFQERSSFGRRIFDRYFAMNSTEPVNIDNSTSKRIRETVESGGFPLDTY 135

  Fly   915 APAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSA 979
            ..||.||..|:|:|.:.||:||                            ||....:|:. ::.|
Worm   136 DVAQYQILHLLKYDCWPRFLRS----------------------------TNNSQPSFTD-EELA 171

  Fly   980 SNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTS-----------ASLK 1033
            ::.||:...|     :.|...:.:..|..|...   .|||    |||..:           |.:.
Worm   172 ADDEDKNGHS-----QPTSLNNTNEFEAAAQQS---QPAP----NAPAATKEKPSKQYSMPAEMT 224

  Fly  1034 LVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTD--GATTIVQTRPGETVGE 1096
            ....:||||..|..|.               ...|..:  |::::.|  ...|:..:.|..:|..
Worm   225 SPVKKNSLSPTHLRRC---------------RPVEPKH--CQLMIGDQFNTETVTLSDPTMSVRR 272

  Fly  1097 LVERLLEKRNLVYPYYDIV--FQGST-----KSIDVQQPSQILAGKEVV------IERRVAFKLD 1148
            ..:.:.:.:.:...:.::|  ..|||     ::||..| |:.|....||      :....:||..
Worm   273 WTQEMADAQGMDRMHVEVVDAETGSTIDPARQAIDALQ-SRALRLVPVVSFIIEFLPANFSFKNP 336

  Fly  1149 LPDP-KVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVM 1212
            ...| |::.::::.......|:||:|.||....:..::::..:...:..:..|... .|:...||
Worm   337 ASTPTKLVCIRARHSLSTGAVLRPLLHKYTLDPQVTRIVLNGSLEQVKRSCAVGQV-SQKCLTVM 400

  Fly  1213 VNSDF--QVGGGS-SMPPKQSKP-MKPLP------------------------------QGHLD- 1242
            ..:.:  :|..|. |:||:.  | :..||                              ..||.
Worm   401 SEAQYSDRVNAGKVSLPPRD--PILSQLPSTIYEQNNFPFHQNGDISYCEIPNESERNKHAHLQH 463

  Fly  1243 ----------ELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGG 1297
                      |.|..:||:.: .||..|.|           ||:..||..:|. :||    ..|.
Worm   464 DGPNAAHQQKEYTLSIFNKFV-RKASHAVS-----------KSDPNPSAGTSQ-DRM----ASGV 511

  Fly  1298 NIPASKLPKLKKKST-------SSSQQSEEAATTQA--VADPKKPIIAKLKAGVKLQVT------ 1347
            ..||:..|....::.       |::|.:..:|:|.:  |::|.|..::..|:..:.:|.
Worm   512 YSPATGGPSFASRAAAGTNFGGSANQVNAGSASTSSNNVSEPSKNRLSIFKSKTEKKVVKPESEK 576

  Fly  1348 ERVAEHQDEL---------------------LEGLKRAQLARLEDQRGTEINFDLPDFLKNKENL 1391
            |::....|::                     .|.|||  :.:..|....|     |..:::....
Worm   577 EKLKPRSDDIPTTSTSTPMAVETKPNGSRTTEEPLKR--MGKSGDDGSQE-----PQGIRHPAIF 634

  Fly  1392 SAAV-SKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQT 1455
            |..: .:.....|..||.:..|:|.|.:          :::...||.|............|...|
Worm   635 STKIGDEAAAAAAGASPSTSAPSTSTSV----------QTKTTTSPTKSPTSTTITTSGTTTSAT 689

  Fly  1456 -EFAKAPPPL 1464
             ..|.||||:
Worm   690 SSVATAPPPV 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	39/114 (34%)
		RGS12_RBD	1073..1145	CDD:176412	16/86 (19%)
		RBD	1144..1213	CDD:128731	13/69 (19%)
rgs-6	NP_001294820.1	RGS	47..157	CDD:214613	37/109 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810