Protein Alignment loco and rgs-7

DIOPT Version :10

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_001360776.1
• Gene: rgs-7 / 180645
• WormBaseID: WBGene00004350
• Length: 824
• Species: Caenorhabditis elegans
• Alignment Length: 1000
• Identity: 200/1000 - (20%)
• Similarity: 333/1000 - (33%)
• Gaps: 367/1000 - (36%)

  Fly    44 TTPSGSNSQQH-----QRRRKKRANYNYNGIRTVEVRRGYNGFG------FTISGQQPCRLSCII 97
            :||..:| ::|     |.||...:::.... |.|..||...|:|      ..:....|.|.|...
 Worm    93 STPQLAN-ERHKEMYSQIRRGDDSSFRSRD-RFVPPRRPRMGYGSSDLSAIELQEMSPIRSSTYS 155

  Fly    98 SSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEEN----- 157
            |||.|.:              |:..:...|...||...: .|.:.....|::    |:||
 Worm   156 SSSEAHR--------------LSSLRAQTEWKPQLTSTT-TSFQPLSPMNHH----DKENGPFKA 201

  Fly   158 -----AHATLRGQLLAASLRHKPRFLHH--------KAKLHRLRNSPQKKLNPPEAVEPHKSKSS 209
                 ..:|.|.|.:   .|..|::...        :::|....:...::...||:...|.:::
 Worm   202 PMSPVCSSTPRSQRM---YRKNPKYRRQFGSSLQLSESRLEESTSQESERAVTPESWMEHNNEN- 262

  Fly   210 PDHPT----LKPVLEDPP------LTANLSKAADVANV---------SAMVRAVGSAALECRV-- 253
             :||.    .||.....|      |....:|..|:..:         ..:...|.:||..|..
 Worm   263 -EHPDQMMFAKPKQGSFPRPEAFGLDNAYAKHKDIRGIIFLSMSLCGRRLTLNVQNAAYFCSAAR 326

  Fly   254 ---IVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATY 315
               :..|:..:...:..|.||      |..|:.||.            ||.            .|
 Worm   327 PTSVCSYVSAVLCHRPSSQSS------SSSRQYRQR------------PDE------------CY 361

  Fly   316 SSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIE 380
            .:..:...:|.|..|:.:|....:.|.:..|...||..:.:|.....:    .|..|.:...|.:
 Worm   362 RTRLVTNCNSPSFDESFYFTFSENCVRDLLIVTVYEMDSNNAEKKRIL----GCMTFPVSRILKK 422

  Fly   381 HAQ-------HLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNL---------VRSMYTMRILPP 429
            .:|       |.:|         :||:.:  :|..|...:::|.         .|.|..:|
 Worm   423 ASQVVGDPFPHYRR---------QDPMED--VEINNEGFFLLNKDQGRKQNFPQRKMLQVR---- 472

  Fly   430 ASRSHQADYE--AGAGAAAAGGAVAAAH--------SPQPSNHSEIS-----TTTSNSD-SGIGF 478
                .|..||  |..|.::||.:|.:.:        ||:.|..:|::     .:|.:|| .|...
 Worm   473 ----RQTFYEDPAFTGVSSAGSSVISNNTGGQMTMASPRLSVPNELTMGDYYRSTGSSDMRGRST 533

  Fly   479 NNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRS 543
            ||          ::|:.:|.:....:| .||                 .:|.:     |.|.|.|
 Worm   534 NN----------LLDYTSASSSTNGSA-GGP-----------------EKLKL-----HRATLPS 565

  Fly   544 PPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSL 608
                                  .|..||..:.||..:|..:.||.....:...|:..::.|.|
 Worm   566 ----------------------ITTTTSENNSDDAKSLSPEQSPTDHHFLCPDDNGGVYGAGP-- 606

  Fly   609 DEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQT 673
                  ||.|.....:||:.:. |.:..|
 Worm   607 ------AHSAIKKSSVRRAASF-TFSPKH------------------------------------ 628

  Fly   674 MDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRS 738
                                  |||...|.:....|.|
 Worm   629 ----------------------SSSKTNLRQLNGREED--------------------------- 644

  Fly   739 DKVAKEQQQ-LGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPP 802
                ||::: ||   |:.||.|...|..|:.:.|    |.|..||...:
 Worm   645 ----KEKKRFLG---PISRTLSYLRSKMDLALST----SSLYPSRDDVR---------------- 682

  Fly   803 SAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERY-RLL 866
                                .|..|||.:|.:..|...|.:|||||||.||:.||..||.: ::.
 Worm   683 --------------------QWEISFESLLNNKFGCALFRQFLKKEFSDENMDFWLECEEFKKMK 727

  Fly   867 ESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKL-ADAAPDIFAPAQKQIFSLMKFDSY 930
            :.:.....:|.||:::.:|.:|...||:||..|:.|:..: |...||.||.||.::..||..|||
 Worm   728 DGKKSTTQKAIEIYSEFVAEHSPKEVNLDSDTRAATKAAVEAGCKPDTFALAQSRVEQLMSKDSY 792

  Fly   931 QRFIRSDLYKSCVEA----EQKNQP 951
            :||:|..|:...:|:    :::::|
 Worm   793 RRFLRDRLFLDLLESYEITDKEDKP 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_RGS12-like	70..145	CDD:467194	18/80 (23%)
		PTB_RGS12	251..391	CDD:269984	27/151 (18%)
		RGS_R12-like	828..941	CDD:188661	45/114 (39%)
		RBD1_RGS12_like	1072..1141	CDD:340515
		RBD2_RGS12_like	1142..1212	CDD:340587
		GoLoco	1354..1375	CDD:214645
rgs-7	NP_001360776.1	C2	310..427	CDD:214577	28/150 (19%)
		RGS	687..792	CDD:459870	40/104 (38%)