DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and mpz-4

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_500654.1	Gene:	mpz-4 / 177255	WormBaseID:	WBGene00019165	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	395	Identity:	69/395 - (17%)
Similarity:	122/395 - (30%)	Gaps:	131/395 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 SSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLR 163
            :||.:.| :..||.::.|||..||                     ..|...::..||....|:|:
Worm    88 ASPFKGA-ILPGDIILQVNGTTVS---------------------FDEKQLTEHVDETTGGASLQ 130

  Fly   164 GQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANL 228
            ..:                                        |:....||..|..|.
Worm   131 SNV----------------------------------------KTVKRKPTTTPKTEP------- 148

  Fly   229 SKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTI- 292
                        |||..|...:.:|:||                         |:...|.:..|
Worm   149 ------------VRAPHSLYPDFKVVVG-------------------------KILNSKSETKIT 176

  Fly   293 VLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSA 357
            ||:....:.:|......|:|||..    :.:..:...:.::..|   .::..|::.:...:....
Worm   177 VLVARLKNRMSTSKIPNGILATQD----HTIDLAILYQFKYLQL---GLNVQQVDRKVVVNYTIP 234

  Fly   358 AAAGHISISHSCHVFVIDTKLIEH-AQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSM 421
            .:..|.|::....:..:|.|.|.. |.:.||   ||.....:....|.:|:| |::.:.|:||..
Worm   235 DSVSHCSLNIGEAIIAVDDKPINTLADNRQR---FREGFEANGWIRLLVEYP-NTDPIKNMVRGQ 295

  Fly   422 YTMRILPPASRSH-------QADYEAGAGAAAAGGAVA----AAHSPQPSNHSEISTTTSNSDSG 475
            .. .::..|.|..       :..:..|..|...|.|:|    ....|......:.....:..|..
Worm   296 LA-NVMRTAERPQYLLCGDVRKYFVEGIEALKNGKALAPILKEEEGPGEVGKKKSDAKVTKKDPA 359

  Fly   476 IGFNN 480
            :||||
Worm   360 VGFNN 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	10/45 (22%)
		PTB_RGS12	251..391	CDD:269984	23/141 (16%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
mpz-4	NP_500654.1	PDZ	<81..130	CDD:381812	14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900