DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and smz-2

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_491965.1	Gene:	smz-2 / 172415	WormBaseID:	WBGene00020661	Length:	274	Species:	Caenorhabditis elegans

Alignment Length:	306	Identity:	63/306 - (20%)
Similarity:	104/306 - (33%)	Gaps:	85/306 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRM-----QIAENYYSDSSDEE 156
            |.:....:..||.||.:..|||.|...         ..:.|.::|.     :|..|.....::|.
Worm    32 IQAGTISEGKLRIGDQVKKVNGQNCKD---------CNDFFRALRFAAPCAKITVNRDEKKAEEL 87

  Fly   157 NAHATL---RGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPV 218
            .|...:   |.::    ::.:..:::..|.|..::|.|:..|.         .|...:...:..|
Worm    88 EARVHIPEDRAKI----IQRREGYVYELATLVWVQNGPKLGLG---------IKHFQNRVLVSRV 139

  Fly   219 LEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKL 283
              ||                      ||.|.:|.|:..:|..::   .|..|.| ...|..:.|.
Worm   140 --DP----------------------GSLAEKCLVLGDHLCDVD---GIPVSDK-DVARDLLVKN 176

  Fly   284 RQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEE 348
            .|||.:.|.|:.  .|||:..:..:...|||      |.:...|...|.....:.|...  |...
Worm   177 IQEKGKVTFVVE--RPDSIDAKQWAKQALAT------NLMQPPSVQMNEDVKGIASQYR--QALP 231

  Fly   349 EYEPSAGSAAAAG----HISISHSCHVFVIDTKLIEHAQHLQRAHE 390
            ..:|.|.||.:.|    .:||             ||..|..:..|:
Worm   232 GLKPPAKSAMSTGPNARRVSI-------------IEQTQTHEIGHD 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	11/52 (21%)
		PTB_RGS12	251..391	CDD:269984	35/144 (24%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
smz-2	NP_491965.1	PDZ_signaling	7..77	CDD:238492	12/53 (23%)
smz-2	NP_491965.1	PDZ_signaling	114..188	CDD:238492	24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900