DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Grip2

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_612544.2 Gene:Grip2 / 171571 RGDID:621668 Length:1043 Species:Rattus norvegicus


Alignment Length:947 Identity:185/947 - (19%)
Similarity:308/947 - (32%) Gaps:318/947 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 RTVEV---RRGYNGFGFTISG--------QQPCRLSCIISSSPAEQAG-LRSGDFLISVNGL--- 119
            :||:|   :.| |.|||.:.|        .:|..|:.:....||::.| |:.||.|:|::|:   
  Rat   150 KTVDVSLYKEG-NSFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLH 213

  Fly   120 ---------NVSKLPHETVVQL---------IGNSFGSIRMQIAENYYS------DSSDEENAHA 160
                     .:.:..||.:.|:         :.|:.|.:.::||:...|      .:....|..|
  Rat   214 GASHATAIATLQQCSHEALFQVEYDVATPDTVANASGPLVVEIAKTPGSALGISLTTGSHRNKPA 278

  Fly   161 TLRGQLLAASLRHKPRFLH-----------------------------HKAKLHRLRNSPQKK-- 194
            ....::..||:..:...||                             .|.:|..| .:||.:  
  Rat   279 ITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEIL-PAPQSRRP 342

  Fly   195 LNPPEAVEPHKSKS--------------SPDH---PTLKP--------VLEDPPLTANLSKAADV 234
            |.|||||...:|:.              .|.|   ||..|        |...|..:..::.|...
  Rat   343 LKPPEAVRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAPGGQDQSRSVSSTPFSSPTMNPAFPC 407

  Fly   235 ANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQ-EKRQPTIVLMCIT 298
            ||.|.:.|    ..:..|...|.    ...::..|.|.|....|.:....| ...:.|.|::|..
  Rat   408 ANASTLPR----GPMSPRTTAGR----RRQRRKEHRSSLSLASSTVGPGGQIVHTETTEVVLCGD 464

  Fly   299 PDS---LSLQSSSGGVLAT---YSSARLNFVSSSSESE--------NRFFGLVTSAVHNTQIEEE 349
            |.|   |.||   ||:.||   .|...:.|:...|.:|        :|...:...|..:..:||.
  Rat   465 PLSGFGLQLQ---GGIFATETLSSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEA 526

  Fly   350 YEPSAGSA------------AAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQ-------- 394
            .:....:|            .|...|..|.:.||.:...:.:|....:..|...|.:        
  Rat   527 NQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIK 591

  Fly   395 --------CTRDP------ISNLCLEF-PNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGA 444
                    .|.:|      |.|:.|:. |  .||.|.::|....:..|........:|.:..:||
  Rat   592 KGSVAHRTGTLEPGDKLLAIDNIRLDHCP--MEYAVQILRQCEDLVKLKIRKDEDNSDEQESSGA 654

  Fly   445 AA-------AGG--AVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLA-AGA 499
            .:       .||  .:..:.:.:|.:...||..|..   |:.......::.||||.::.:: .|.
  Rat   655 VSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKR---GLAERTGAIHVGDRILAINSVSLKGR 716

  Fly   500 GAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQS 564
            ..:.|.|              ::.:....:|::             ....|.||       |:..
  Rat   717 PLSEAIH--------------LLQVAGETVTLK-------------IKKQLDRP-------LLPR 747

  Fly   565 PATNLTSTRSCDDVLNLFVDDSPRTL----------AAVASMDDISLHSAAPSLDEGHTFAHPAC 619
            .:.:|:.....|       :|.|..|          .||.|:|. ::.|...|..||......:.
  Rat   748 QSGSLSEASDVD-------EDPPEALKGGLLTTHFSPAVPSVDS-AVESWGSSATEGGFGGSGSY 804

  Fly   620 VPRKMRRSLALE-----------TPTTPHKLS------AQVFGQ-------------PGSRHSLG 654
            .|:...||:..:           .|..|.:.|      .:.|.:             ||.....|
  Rat   805 TPQVAVRSVTPQEWRSSRLKSSPPPLEPRRTSYTPGPTDESFPEEEEGDWEPPMSPAPGPAREEG 869

  Fly   655 F-----EAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGN 714
            |     ||::.::|     |....:     |:.|..|....|..|.         |.:..|  |:
  Rat   870 FWRVLGEALEDLES-----CGQSEL-----LRELEASIMTGTVQSV---------AVDGRP--GS 913

  Fly   715 RALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQ---------------SSPVRRTASMNASD 764
            |       |:|           ||.:|....:.|.:               ..|||.....:.||
  Rat   914 R-------PWR-----------RSREVGTSPEDLQELLLPTPLEMHRVTLHKDPVRNDFGFSVSD 960

  Fly   765 ----NDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLT 797
                ..:|:.|:.:|...:....|....||||..|.|
  Rat   961 GLLEKGVYVHTVRIDGPAQHGGLQPFDRLLQVNHVRT 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 25/107 (23%)
PTB_RGS12 251..391 CDD:269984 35/166 (21%)
RGS_R12-like 828..941 CDD:188661
RGS12_RBD 1073..1145 CDD:176412
RBD 1144..1213 CDD:128731
Grip2NP_612544.2 PDZ_signaling 51..133 CDD:238492
PDZ_signaling 153..236 CDD:238492 21/83 (25%)
PDZ_signaling 251..334 CDD:238492 11/82 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 371..450 18/86 (21%)
PDZ_signaling 456..544 CDD:238492 21/90 (23%)
PDZ_signaling 557..640 CDD:238492 16/84 (19%)
PDZ_signaling 657..737 CDD:238492 15/109 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 745..769 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 786..863 11/76 (14%)
PDZ_signaling 941..1020 CDD:238492 15/57 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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