DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and FRMPD2

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_001018081.4 Gene:FRMPD2 / 143162 HGNCID:28572 Length:1309 Species:Homo sapiens


Alignment Length:837 Identity:153/837 - (18%)
Similarity:244/837 - (29%) Gaps:337/837 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ITGASG---STAV------GTGAAAAE--DASPAAN-------------------SGPAPISTST 44
            :.||:|   ||::      |:..|.||  ..||...                   ||| |:.:..
Human   691 LQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTWDSLSGP-PVQSMH 754

  Fly    45 TPSGSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNGFGFTI-----SGQQP--CRLSCIISSSPA 102
            ..|.:|     ||:...|......:|....|..:.||||.|     |||..  ..:|.||...||
Human   755 AGSKNN-----RRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPA 814

  Fly   103 EQA-GLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAEN--YYSDSSDEENAHATLRG 164
            |:| .::.|..::::|.:::........|::|.||..:|.:.|:::  ...::.|||        
Human   815 EKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEE-------- 871

  Fly   165 QLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLS 229
                                   :||                                  |||..
Human   872 -----------------------KNS----------------------------------TANSG 879

  Fly   230 -KAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSS---------KLQTVRSCIRKLR 284
             .:.|:.:                  .||.|::     :||:.         .:..|:|.:.:||
Human   880 VSSTDILS------------------FGYQGSL-----LSHTQDQDRNTEELDMAGVQSLVPRLR 921

  Fly   285 QEKRQPTIVLMCITPDSLSLQSSSGGVLA------TYSSARLNFVSSSSESENRFF----GLVTS 339
            .:               ||.....|...:      ..|:..:.||....|.....|    |:.||
Human   922 HQ---------------LSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTS 971

  Fly   340 AVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDP--ISN 402
            ..:.....:...| .|.||..|  .|.....:..:|..::....|.|     .:||...|  ::.
Human   972 VPYGGIYVKSIVP-GGPAAKEG--QILQGDRLLQVDGVILCGLTHKQ-----AVQCLTGPGQVAR 1028

  Fly   403 LCLE--FPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAA-----GGAVAAAHSPQPS 460
            |.||  .|.:::..              |::.....|.........|     ...|:....|   
Human  1029 LVLERRVPRSTQQC--------------PSANDSMGDERTAVSLVTALPGRPSSCVSVTDGP--- 1076

  Fly   461 NHSEISTTTSNSDSGIGFN------NDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPL 519
               :.......:.:|:||:      ..|:::...::.:..|..|               .||...
Human  1077 ---KFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG---------------QPAEEN 1123

  Fly   520 GIVGIPDNRLTV-----------------RAMPDHSALL--RSPPAS-----SSLRRPNLLASFN 560
            |.:...|..|.|                 |..|....||  |.||.:     ...:.|.|.|   
Human  1124 GAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSA--- 1185

  Fly   561 LIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMR 625
              ....|..|.|.||         .||     :...:|....||:|...||              
Human  1186 --DKEFTRATCTDSC---------TSP-----ILDQEDSWRDSASPDAGEG-------------- 1220

  Fly   626 RSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDR 690
              |.|...::...:....:||...|                         .|||           
Human  1221 --LGLRPESSQKAIREAQWGQNRER-------------------------PWAS----------- 1247

  Fly   691 TSMSASSSSH---CLLE--------ATNSEPDLGNRALPANASPFRRAWGQSSFRTP 736
             |::.|..||   |.|.        ||:.|.|:.....  :.....|. |:.||.:|
Human  1248 -SLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCY--SVCDIMRL-GRYSFSSP 1300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 24/83 (29%)
PTB_RGS12 251..391 CDD:269984 29/158 (18%)
RGS_R12-like 828..941 CDD:188661
RGS12_RBD 1073..1145 CDD:176412
RBD 1144..1213 CDD:128731
FRMPD2NP_001018081.4 KIND 15..197 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..249
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..302
B41 346..550 CDD:214604
FERM_C_PTPH13 546..647 CDD:270008
PDZ_signaling 773..857 CDD:238492 24/83 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..880 8/85 (9%)
PDZ 947..1034 CDD:214570 22/94 (23%)
PDZ 1078..1167 CDD:214570 17/103 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1204..1228 8/39 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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