DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Patj

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	1681	Identity:	322/1681 - (19%)
Similarity:	520/1681 - (30%)	Gaps:	630/1681 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VEVRRGYNGFGFTISGQQPCR--LSCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPHETVVQLI 133
            ||:....:|.||.|.|.:...  :..|:....|::.| |::||.::.:...||..:..|.|.|::
  Rat   249 VELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGMTSEQVAQVL 313

  Fly   134 GNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPP 198
            .|...|:||.:|.:...:.:                                         :.||
  Rat   314 RNCGNSVRMLVARDPVGEIA-----------------------------------------VTPP 337

  Fly   199 EAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEM 263
                     :....|...||:....|.:: |...:..||. :|:..|. :|..| ||||:||..
  Rat   338 ---------TPASLPVALPVVATRTLGSD-SSPFETYNVE-LVKKDGQ-SLGIR-IVGYVGTAH- 388

  Fly   264 PKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSE 328
            |.:.|                      .|.:..|.|.|
  Rat   389 PGEAS----------------------GIYVKSIIPGS--------------------------- 404

  Fly   329 SENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRL 393
                      :|.||.||:..     ....|...::|....:..|:
  Rat   405 ----------AAYHNGQIQVN-----DKIVAVDGVNIQGFANQDVV------------------- 435

  Fly   394 QCTRDPISNLCLEFPNNSEYVVN--LVRSMYTMRILP---PASRSHQADYEAGAGAAAAGGAVAA 453
                        |...|:..||:  |||...::...|   |:||.                  |.
  Rat   436 ------------EVLRNAGQVVHLTLVRRKTSLSASPFEQPSSRE------------------AV 470

  Fly   454 AHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARP 518
            |..|      |:...|.:.........:...|.:|:   |.|...   ...|...|..||.
  Rat   471 AEPP------EVPELTGSLKPETNSRMEAEEIGERL---DNLRKD---TVQALEKPDVYPE---- 519

  Fly   519 LGIVGIPDNRLTVR----AMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVL 579
             .|.|.|:|.|..|    ..||:..::.:                          ..|:..|
  Rat   520 -DIPGCPENELKSRWENLLGPDYEVMVAT--------------------------LDTQIAD--- 554

  Fly   580 NLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHKL----- 639
                |:..:..:.:..:..:.|.....|.| ||.:.          .|:|...|.....|
  Rat   555 ----DEELQKYSKLLPIHTLRLGMEVDSFD-GHHYI----------SSIAPGGPVDTLNLLQPED 604

  Fly   640 ------SAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSS 698
                  ..|::|: ..|.::.|  :..|....:..|..:..|..||:.      :.||...:
  Rat   605 ELLEVNGVQLYGK-SRREAVSF--LKEVPPPFTLVCCRRLFDDEASVD------EPRTVEPS--- 657

  Fly   699 SHCLLEA-------TNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRR 756
               ||||       .::|.|.|..||          |                       ||
  Rat   658 ---LLEAEVDRSVDVSTEDDDGELAL----------W-----------------------SP--- 683

  Fly   757 TASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHG-- 819
                       .:||:.|..|.|..    ..|:|.....| .|.....:..|:.|:|.|:..|
  Rat   684 -----------EVKTVELVKDCKGL----GFSILDYQDPL-DPMRSVIVIRSLVADGVAERSGEL 732

  Fly   820 CPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHL 884
            .|.....|......|.|.:....|.||.  ....:.....|:  .|:|.|.:   :..|.|..|
  Rat   733 LPGDRLVSVNEFSLDNATLAEAVEVLKA--VPPGVVHLGICK--PLVEEEKE---EKEEHFIFH- 789

  Fly   885 ANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKN 949
            :||:.|    :|::.....|                             |.|.|   .:||.|..
  Rat   790 SNNNGD----NSESPETVHE-----------------------------IHSSL---ILEAPQGF 818

  Fly   950 QPLPYSGLDLDELLKTNF-HLGAFSKL--KKSASNAEDRRRKSLLPWHRKTRSKSR-----DRTE 1006
            :..||    |:||:...| .||...:.  |...|::|.......|....:.|.:.|     :..|
  Rat   819 RDEPY----LEELVDEPFLDLGKSLQFQQKDMDSSSEAWEMHEFLSPRLERRGEEREMLVDEEYE 879

  Fly  1007 IMADMQHALMPAPPVPQNAPLTSAS--LKLVCGQNSL-SDL--------HSSRSSLSSF-----D 1055
            |..|....:...||.|.....||||  |.|..|...| :||        |.:.|.::::     |
  Rat   880 IYQDRLRDMEAHPPPPHIREPTSASPRLDLQAGPQWLHADLSGGEILECHDTESMMTAYPQEMQD 944

  Fly  1056 AGTATGGQGASTESVYSLCRVILTD--GATTIVQTRP----GETVGE--LVERLLEKRNLVYPYY 1112
            ...:|                  ||  ..|..:.:||    .|..|:  ..:.|....:||....
  Rat   945 YSFST------------------TDMMKETFGLDSRPPMPSSEGNGQHGRFDDLEHLHSLVSHGL 991

  Fly  1113 DIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLD---LPDPKVISVKSKPKKQLHEVIRPILS 1174
            |:   |.....|:|.|. :|.....|.:||...:|.   ||..:|:   :||...    :..:.|
  Rat   992 DL---GMMTPSDLQGPG-VLVDLPAVTQRREQEELPLYRLPSARVV---TKPSSH----VGMVSS 1045

  Fly  1175 KY----------------------NYKMEQVQVIMRDTQVPIDLN----QPV--TMADGQRLRIV 1211
            ::                      ::...::..|.|:..|.:.::    |.|  .:.:|:.|:.:
  Rat  1046 RHANAACELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGI 1110

  Fly  1212 MVNSDFQVGGGSSMPPKQSKPMKP----LPQGHLDELTNKVFNELLASKADAAASEKS--RPV-- 1268
            .:....:     ..|..::|.:|.    |....:| |.|       ||.|:|..:.||  .||
  Rat  1111 FIKQVLE-----DSPAGKTKALKTGDKILEVSGVD-LQN-------ASHAEAVEAIKSAGNPVVF 1162

  Fly  1269 ---DLCSM--------KSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEE-A 1321
               .|.|.        ...:.|.:......:.::.:|.|...|..|||...:..::.:::||| :
  Rat  1163 VVQSLSSTPRVIPSVNNKGKTPPQNQDQNTQEKKAKRHGTAPPPMKLPPPYRAPSADTEESEEDS 1227

  Fly  1322 ATT-----QAVAD-PKKPIIAKLK----------AGVK-----------------------LQVT 1347
            |.|     |..|| |.:..|.:|:          ||.|                       ::|.
  Rat  1228 ALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPDGPAAADGRMRVG 1292

  Fly  1348 ERVAEHQDELLEG---------LKRA----------------QLA------------RLEDQRGT 1375
            :.:.|..:::|.|         :|.|                |:|            .:||..||
  Rat  1293 DELLEINNQILYGRSHQNASAIIKTAPTRVKLVFIRNEDAVNQMAVAPFPVPSHSPSPVEDLGGT 1357

  Fly  1376 E-------INFD---LPDFLKNK-ENLSAAVSK---LRKVRASLSPVSKVPATPTEIPQPAPRLS 1426
            |       .:.|   ||:...:| |:|:.||..   ..:.:||.||.|    ...::.||.....
  Rat  1358 EPVSSEEDSSVDAKPLPERESSKPEDLTQAVDDSMVAEQEKASESPDS----AARQMKQPGYSAQ 1418

  Fly  1427 ITRSQQ--PVSPMKVDQEPETDLPAATQDQTEFAKAPPPLPPKPKVLPIKP------------SN 1477
            ::.|.|  |.:|..:.|....|:..:...|...:..|.||...|...||.|            |.
  Rat  1419 VSSSSQEIPSAPAPLCQSTHADVTGSGNFQAPLSVDPAPLSVDPATCPIVPGQEMIIEISKGRSG 1483

  Fly  1478 WGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKIPLDLG--RKSLEEAGSRCA 1531
            .|::...|                |:...||   ..:|..:|  .|.|:|..|:.|
  Rat  1484 LGLSIVGG----------------KDTPLPG---GSLPTKVGVWEKKLQEMMSQDA 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	22/75 (29%)
		PTB_RGS12	251..391	CDD:269984	21/139 (15%)
		RGS_R12-like	828..941	CDD:188661	20/112 (18%)
		RGS12_RBD	1073..1145	CDD:176412	19/79 (24%)
		RBD	1144..1213	CDD:128731	14/99 (14%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492	22/75 (29%)
		PDZ_signaling	366..450	CDD:238492	29/182 (16%)
		CtpA	<391..>511	CDD:223864	33/244 (14%)
		PDZ_signaling	572..636	CDD:238492	14/77 (18%)
		PDZ	684..773	CDD:214570	22/97 (23%)
		PDZ_signaling	1074..1165	CDD:238492	22/103 (21%)
		PDZ	1244..1329	CDD:214570	11/84 (13%)
		PDZ	1471..1578	CDD:214570	13/69 (19%)
		PDZ_signaling	1590..1670	CDD:238492
		PDZ_signaling	1731..1816	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810