DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Patj

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_766284.2 Gene:Patj / 12695 MGIID:1277960 Length:1834 Species:Mus musculus


Alignment Length:1595 Identity:278/1595 - (17%)
Similarity:511/1595 - (32%) Gaps:522/1595 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 VEVRRGYNGFGFTISGQQPCR--LSCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPHETVVQLI 133
            ||:....:|.||.|.|.:...  :..|:....|::.| |::||.::.:.|.||..:..|.|.|::
Mouse   249 VELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVL 313

  Fly   134 GNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPP 198
            .|...|:||.:|.:...:.:                                         :.||
Mouse   314 RNCGNSVRMLVARDPVGEIA-----------------------------------------VTPP 337

  Fly   199 EAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEM 263
            ..|         ..|...|.:....|.::.| ..:..:|. :|:..|. :|..| ||||:||.. 
Mouse   338 TPV---------SLPVALPAVATRTLDSDRS-PFETYSVE-LVKKDGQ-SLGIR-IVGYVGTAH- 388

  Fly   264 PKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSE 328
            |.:.|                      .|.:..|.|.|                           
Mouse   389 PGEAS----------------------GIYVKSIIPGS--------------------------- 404

  Fly   329 SENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRL 393
                      :|.||.||:..     ....|...::|....:..|:                   
Mouse   405 ----------AAYHNGQIQVN-----DKIVAVDGVNIQGFANQDVV------------------- 435

  Fly   394 QCTRDPISNLCLEFPNNSEYVVN--LVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHS 456
                        |...|:..||:  |||...::...|   ..|.:..|.   .|........|.|
Mouse   436 ------------EVLRNAGQVVHLTLVRRKTSLSASP---FEHSSSRET---VAEPPKVPERAGS 482

  Fly   457 PQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGI 521
            |:|    |.:.:....:.|...:|...|                 ...|...|..||..     :
Mouse   483 PKP----EANLSVEAEEIGERLDNLKNN-----------------TVQALEKPDVYPEK-----V 521

  Fly   522 VGIPDNRLTVR----AMPDHSALLRSPPA----SSSLRRPNLLASFNLIQSPATNLTSTRSCDDV 578
            .|.|:|.|..|    ..||:..::.:..|    ...|::.:.|...:.::               
Mouse   522 PGSPENELKSRWENLLGPDYEVMVATLDAQIADDEELQKYSKLLPIHTLR--------------- 571

  Fly   579 LNLFVD--DSPRTLAAVA---SMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHK 638
            |.:.||  |....:::||   .:|.::|......|.|.:                          
Mouse   572 LGMEVDSFDGHHYISSVAPGGPVDTLNLLQPEDELLEVN-------------------------- 610

  Fly   639 LSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLL 703
             ..|::|: ..|.::.|  :..|....:..|..:..|..||:.      :.||...|      ||
Mouse   611 -GMQLYGK-SRREAVSF--LKEVPPPFTLVCCRRLFDDEASVD------EPRTMEPA------LL 659

  Fly   704 EA-------TNSE-PDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQS-----SPVR 755
            ||       .|.| .|.|..||          |...    .::.::.|:.:.||.|     .|:.
Mouse   660 EAEVDHSVDVNIEDDDDGELAL----------WSPE----VKTVELVKDCKGLGFSILDYQDPLD 710

  Fly   756 RTASMNASDNDMYIKTLMLDSDLKSSR--------------SQHQLSLLQVPKVLTTPAPPSAIT 806
            .|.|:      :.|::|:.|...:.|.              |....:|.:..:||.. .||..:.
Mouse   711 PTRSV------IVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEVLKA-VPPGVVH 768

  Fly   807 ASV----------------------AAEGAAQDHGCPSSWAGSFERMLQDAAGMQTF-------- 841
            ..:                      ::|.|...|...||......:..:|...::..        
Mouse   769 LGICKPLVEDEKEERFSLHSNNNGDSSEPADAVHEIHSSLILEAPQGFRDEPYLEELVDEPFLDL 833

  Fly   842 ---SEFLKKEFSAENIYFWTACERYRLLESEADRVAQAR--------EIFAKHLANNSSDPVNVD 895
               .:|.:|:..:.:    .|.|.:..|....|...:.|        |::..||....|:|    
Mouse   834 GKSLQFQQKDVDSSS----EAWEMHEFLSPPLDGRGEEREMLVDEEYELYQDHLRAMESNP---- 890

  Fly   896 SQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDL----YKSCVEAE-------QKN 949
                  ....:.:|||  .:|       :::..:..:::.::|    ...|.:||       |:.
Mouse   891 ------PPPHIREAAP--ASP-------VLELQAGTQWLHANLSGGERLECHDAESMMSAYPQEM 940

  Fly   950 QPLPYSGLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQ-- 1012
            |...||..|   :::..|.|.:.:.:..|..|.:..|...:...|..|.|.......|.:|:|  
Mouse   941 QQYSYSTAD---MMEETFGLDSRAPIPSSEGNGQHGRFDDMGHLHSLTSSSLDLGMMIPSDLQGP 1002

  Fly  1013 HALMPAPPVPQ-----NAPL-TSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTES-- 1069
            ..|:..|.|.|     :.|| ...|.::|...:|...|.|||.:.::.:......|:|..|.:  
Mouse  1003 GVLVDLPAVAQRREQEDLPLYRLPSARVVTKPSSHMGLVSSRHANAACELPEREEGEGEETPNFS 1067

  Fly  1070 ------VYSLCR-------VILTDGATTIVQTRPGETV-GELVERLLE-----KRNLVYPYYDIV 1115
                  :..:.|       :.:..|.|.|.:.:.||.: |..::::||     |.|.:.....|:
Mouse  1068 HWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL 1132

  Fly  1116 FQGSTKSIDVQQPSQI-------LAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPIL 1173
               ....:|:|..|..       .||..||.             .|.|:.|.|:         ::
Mouse  1133 ---EVSGVDLQNASHAEAVEAIKSAGNPVVF-------------VVQSLSSTPR---------VI 1172

  Fly  1174 SKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQ 1238
            ...|.|.:        |..|   ||.....:.:..|           .|::.||.:..|....|.
Mouse  1173 PTVNNKGK--------TPAP---NQDQNTQERKAKR-----------HGTAPPPMKLPPPYRAPS 1215

  Fly  1239 GHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRD-GGNIPAS 1302
            ..::           .|:.|.|.::|                       ::|::..| .|.:...
Mouse  1216 ADME-----------GSEEDCALTDK-----------------------KIRQRYADLPGELHII 1246

  Fly  1303 KLPKLKK---KSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRA 1364
            :|.|.|.   .|.:.::.....:......:|:.|    ..|..::::.:.:.|..:::|.|....
Mouse  1247 ELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGP----AAADGRMRIGDELLEINNQILYGRSHQ 1307

  Fly  1365 QLARLEDQRGTEINFDLPDFLKNKENLS-AAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSIT 1428
            ..:.:.....|.:..   .|::|::.:| .||:...::..|.|||..:..|.....:....:...
Mouse  1308 NASAIIKTAPTRVKL---VFIRNEDAVSQMAVAPFPELSHSPSPVEDLGGTELVSSEEESSVDAK 1369

  Fly  1429 RSQQPVS--PMKVDQEPETDLPAATQDQTEFAKAPPPLPPKPKVLPIKPSNWGVAQPTGNYCNKY 1491
            ...:|.|  |..:.|..:.::.|..|.::|        .|......||...:.....:.:..:..
Mouse  1370 HLPEPESSKPEDLSQVVDDNMVAEQQKESE--------SPDSAACQIKQQTYSTQVSSSSQDSPS 1426

  Fly  1492 SPSKQVPTSPKEASKPGTFASKIPLDLGRKSLEEA 1526
            ||:....::..:.:..|.|.:.:|:|....|::.|
Mouse  1427 SPAPLCQSAHADVTGSGNFQAPLPVDPAPLSVDPA 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 23/75 (31%)
PTB_RGS12 251..391 CDD:269984 21/139 (15%)
RGS_R12-like 828..941 CDD:188661 18/135 (13%)
RGS12_RBD 1073..1145 CDD:176412 19/91 (21%)
RBD 1144..1213 CDD:128731 11/68 (16%)
PatjNP_766284.2 L27_2 8..65 CDD:312549
PDZ_signaling 135..218 CDD:238492
PDZ_signaling 248..325 CDD:238492 23/75 (31%)
PDZ_signaling 363..450 CDD:238492 29/185 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..488 9/41 (22%)
PDZ_signaling 572..636 CDD:238492 15/93 (16%)
PDZ 685..774 CDD:214570 17/99 (17%)
PDZ_signaling 1072..1163 CDD:238492 19/106 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1171..1219 12/69 (17%)
PDZ 1242..1327 CDD:214570 12/91 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1340..1453 20/120 (17%)
MPDZ_u10 <1453..1468 CDD:374710 2/9 (22%)
PDZ 1469..1554 CDD:214570
PDZ_signaling 1566..1646 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1657..1676
PDZ_signaling 1707..1792 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1811..1834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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