Protein Alignment loco and Axin2

DIOPT Version :10

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_056547.3
• Gene: Axin2 / 12006
• MGIID: 1270862
• Length: 840
• Species: Mus musculus
• Alignment Length: 874
• Identity: 168/874 - (19%)
• Similarity: 299/874 - (34%)
• Gaps: 229/874 - (26%)

  Fly   792 VPKVLTTPAPPSAITASVAAEGAAQDHG--CPSS----WAGSFERMLQDAAGMQTFSEFLKKEFS 850
            |.||.:|...|.:..|....:|..:..|  .|.|    |..|...:|.|..|...|..||::|..
Mouse    40 VGKVQSTKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKC 104

  Fly   851 AENIYFWTACERYR---LLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPD 912
            .:.:.||.||..:|   |.:::..|||:|  |:.:::.|||.    |..|.:..|:..:.|....
Mouse   105 VDTLDFWFACNGFRQMNLKDTKTLRVAKA--IYKRYIENNSV----VSKQLKPATKTYIRDGIKK 163

  Fly   913 ------IFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGA 971
                  :|..||.:|.::|:.::||.|:.||:|...|.:..:|.....:| .|..|.....:|..
Mouse   164 QQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNG-GLGSLKVLCGYLPT 227

  Fly   972 FSKLKK-SASNAEDRRRKSLLPWHRKT-RSKSRDR-TEIMADMQHALMPAPPV-PQN-------A 1025
            .::.:: :.::.:.:...:::....|| |:.:..| ||...:...:...:.|| |.:       |
Mouse   228 LNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSDPVNPYHVGSGYVFA 292

  Fly  1026 PLTSASLKLVCGQNSLSDLHSSRSSLSSFDA---GTATGGQGASTESVYSLCRVILTDGATTI-- 1085
            |.|||:      .:.||....:..|:|..|:   |......|:..:....:.|.:..:|..::
Mouse   293 PATSAN------DSELSSDALTDDSMSMTDSSVDGVPPYRMGSKKQLQREMHRSVKANGQVSLPH 351

  Fly  1086 -----------VQTRPGETVGELVERL------LEKRN-----LVYPYYDIVFQGSTKSID---- 1124
                       ....|.....||:.||      ||.|:     |.....|...:||.:::.
Mouse   352 FPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEGSEQALSSRDG 416

  Fly  1125 --VQQPSQILAG------KEVVIERRVAFKLDLP---DPKV--ISVKSKPKKQLHEVIRPILSKY 1176
              ||.|..:|..      .:.:::..::..|..|   .|.|  .|.:|:.....|:
Mouse   417 APVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHQ--------- 472

  Fly  1177 NYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHL 1241
            ::..:|...::           |.                     |..:||..:.|:........
Mouse   473 HHHHQQCHTLL-----------PT---------------------GGKLPPVAACPLLGGKSFLT 505

  Fly  1242 DELTNKVFNELLASKA--------DAAASE------------------KSRP--------VDLCS 1272
            .:.|..|.:..:...|        :|.|::                  ||.|        ...|.
Mouse   506 KQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHPKAPEPLPGEQFCG 570

  Fly  1273 MKSNEAPSETSSLFE-RMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIA 1336
            .:....|...:...| .:....||||...|:..|:|..:....||...:...........||..|
Mouse   571 SRGGTLPKRNAKGTEPGLALSARDGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQSKSKPHSA 635

  Fly  1337 K-LKAGVKLQVT-----ERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAV 1395
            : ::....|:..     |||:.|                                    :|..|.
Mouse   636 QSIRKSYPLESACAAPGERVSRH------------------------------------HLLGAS 664

  Fly  1396 SKLRKVRASLSPVSKVPATP--------TEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQ 1452
            ...|.| |...|.::.||.|        .::.:...||:.....|........|:.:.:..||.|
Mouse   665 GHSRSV-ARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHSAAGQ 728

  Fly  1453 -DQTEFAKAPPPLPPKPKVLPIKPSNWGVAQP-----TGNYCNKYSPSKQVPTSPKEASKPGTFA 1511
             ..:.||.  |.|.|:....|.|.::....|.     |..:|.:..|.:::           ..|
Mouse   729 AGASPFAN--PSLAPEDHKEPKKLASVHALQASELVVTYFFCGEEIPYRRM-----------LKA 780

  Fly  1512 SKIPLDLGRKSLEEAGSRCAYLDEPSSSF 1540
            ..:.|...::.|.:.|:...|..:.|..|
Mouse   781 QSLTLGHFKEQLSKKGNYRYYFKKASDEF 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_RGS12-like	70..145	CDD:467194
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	36/121 (30%)
		RBD1_RGS12_like	1072..1141	CDD:340515	18/104 (17%)
		RBD2_RGS12_like	1142..1212	CDD:340587	9/74 (12%)
		GoLoco	1354..1375	CDD:214645	0/20 (0%)
Axin2	NP_056547.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		10/34 (29%)
		AXIN1_TNKS_BD	10..75	CDD:465215	10/34 (29%)
		Tankyrase-binding motif	21..30
		RGS_Axin	82..198	CDD:188662	36/121 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..363		9/62 (15%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		15/85 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..435		7/36 (19%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..478		11/73 (15%)
		Axin_b-cat_bind	433..468	CDD:462616	6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..485		8/57 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..614		9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..745		9/31 (29%)
		DAX	758..840	CDD:197474	10/63 (16%)