DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and Axin1

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001381310.1	Gene:	Axin1 / 12005	MGIID:	1096327	Length:	863	Species:	Mus musculus

Alignment Length:	858	Identity:	171/858 - (19%)
Similarity:	260/858 - (30%)	Gaps:	341/858 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   776 SDLKSSRS-----QHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDA 835
            :.:||..|     :..|.|...|:...:|.||..                  .||.|...:|.|.
Mouse    50 TSIKSETSTATPRRSDLDLGYEPEGSASPTPPYL------------------RWAESLHSLLDDQ 96

  Fly   836 AGMQTFSEFLKKEFSAENIYFWTACERYRLLE----SEADRVAQAREIFAKHLANNSSDPVNVDS 896
            .|:..|..|||:|..|:.:.||.||..:|.||    :|..|:..||.|:.|::.:::.   .|..
Mouse    97 DGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNG---IVSR 158

  Fly   897 QARSLTEEKLADAA------PDIFAPAQKQIFSLMKFDSYQRFIRSDLY-----------KSC-- 942
            |.:..|:..:.|..      |.:|..||.:|.|.|:.::|..|::||:|           |.|
Mouse   159 QTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSD 223

  Fly   943 -----------------------------VEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKS 978
                                         .:.:....|||.|.|....||:|     |..:...|
Mouse   224 QSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLET-----AAPRAPSS 283

  Fly   979 ASNAEDRR------RKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCG 1037
            ....|.|.      |:.:.|::              .:..:||         ||.|||:
Mouse   284 RRYNEGRELRYGSWREPVNPYY--------------VNSGYAL---------APATSAN------ 319

  Fly  1038 QNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLL 1102
                   .|.:.|||| ||.|.:                 |||.:...:
Mouse   320 -------DSEQQSLSS-DADTLS-----------------LTDSSVDGI---------------- 343

  Fly  1103 EKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPD-------PKVISVKSK 1160
                   |.|.|..|...   ::|:..|:..            ::.||.       ||.|.|  :
Mouse   344 -------PPYRIRKQHRR---EMQESIQVNG------------RVPLPHIPRTYRMPKEIRV--E 384

  Fly  1161 PKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSM 1225
            |:|...|:|        :::|.|| ..|:.:..::          :||:.|.:..:   |....|
Mouse   385 PQKFAEELI--------HRLEAVQ-RTREAEEKLE----------ERLKRVRMEEE---GEDGEM 427

  Fly  1226 P--PKQSKPMKPLPQGH-------------------------LDELTNKVFN------------- 1250
            |  |..|..:..:|..|                         |||...:|..
Mouse   428 PSGPMASHKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRS 492

  Fly  1251 -----------------------ELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQ 1292
                                   ..|..|.|.|.....|.|......::..|.|.... |..||.
Mouse   493 PDSGHVAKTAVLGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEA-EVARRV 556

  Fly  1293 QRD-------------------------------GGNIPASKLPKLKKKSTSSSQQSEEAATTQA 1326
            |..                               ||...|......||..:..:..:|..:||:.
Mouse   557 QSSFSWGPETHGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTED 621

  Fly  1327 VADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENL 1391
             |:..:.|:..:..|.|.....|.|.|..   .||::.|..  |..|        |..::....:
Mouse   622 -AEKNQKIMQWIIEGEKEISRHRKAGHGS---SGLRKQQAH--ESSR--------PLSIERPGAV 672

  Fly  1392 SAAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTE 1456
            ...||  .::|.|:.|.......||..|.|||                  .|.|.|..|.:...|
Mouse   673 HPWVS--AQLRNSVQPSHLFIQDPTMPPNPAP------------------NPLTQLEEARRRLEE 717

  Fly  1457 FAKAPPPLPPKPK 1469
            ..|....||.|.:
Mouse   718 EEKRANKLPSKQR 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	38/133 (29%)
		RGS12_RBD	1073..1145	CDD:176412	9/71 (13%)
		RBD	1144..1213	CDD:128731	17/75 (23%)
Axin1	NP_001381310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		7/30 (23%)
		Axin_TNKS_binding	11..80	CDD:211424	7/29 (24%)
		Tankyrase-binding motif	20..29
		RGS_Axin	89..209	CDD:188662	38/122 (31%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:15526030	209..338		33/187 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..240		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..268		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..344		14/82 (17%)
		Interaction with GSK3B. /evidence=ECO:0000250	348..432		24/122 (20%)
		Interaction with beta-catenin. /evidence=ECO:0000250	433..501		7/67 (10%)
		Axin_b-cat_bind	464..495	CDD:400956	4/30 (13%)
		Interaction with RNF111. /evidence=ECO:0000250	505..758		53/261 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..624		17/96 (18%)
		Interaction with PPP2CA. /evidence=ECO:0000250	572..790		41/193 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..664		8/34 (24%)
		Interaction with HIPK2. /evidence=ECO:0000269\|PubMed:15526030	678..753		18/71 (25%)
		DIX	783..860	CDD:395628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810