Protein Alignment loco and PARD3B

DIOPT Version :9

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_011508854.1
• Gene: PARD3B / 117583
• HGNCID: 14446
• Length: 1213
• Species: Homo sapiens
• Alignment Length: 1165
• Identity: 218/1165 - (18%)
• Similarity: 345/1165 - (29%)
• Gaps: 479/1165 - (41%)

  Fly     7 PLPITGASG-STAVGTGAAAAE-DASPAANS---------GPAPISTSTTP-SGSNSQQHQRRRK 59
            |.|:.|.|| .||..||..:.| |||.:...         |..|.|.|.:| .|..|.::.::.|
Human   327 PPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 391

  Fly    60 KRANYNYNGIRTVEVRRGYNGFGFT-------ISGQQPCRLSCIISSSPAEQAG-LRSGDFLISV 116
                        :::::|..|.|||       |.|..|..:..|:....|.:.| |:|||.::.|
Human   392 ------------IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 444

  Fly   117 NGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASL---RHKPRFL 178
            ||.:|:....|.:|.::                         .:|.:|:  .|||   |.:..||
Human   445 NGRDVTGRTQEELVAML-------------------------RSTKQGE--TASLVIARQEGHFL 482

  Fly   179 HHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRA 243
                                    |.:.|..||...|           :|..:..:
Human   483 ------------------------PRELKGEPDCCAL-----------SLETSEQL--------- 503

  Fly   244 VGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSS 308
                            |.|:|...|.|:.|..      .|:..|.:.|...:.|...|:    ..
Human   504 ----------------TFEIPLNDSGSAGLGV------SLKGNKSRETGTDLGIFIKSI----IH 542

  Fly   309 GGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFV 373
            ||  |.:...||..                    |.|:          .|..|...:..|.|
Human   543 GG--AAFKDGRLRM--------------------NDQL----------IAVNGESLLGKSNH--- 572

  Fly   374 IDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADY 438
                  |..:.|:|:                :....|       :|.|..:.||....|..:...
Human   573 ------EAMETLRRS----------------MSMEGN-------IRGMIQLVILRRPERPMEDPA 608

  Fly   439 EAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDR----ILVVDFLAAGA 499
            |.||.:           .|...|.....||:..:|:.|.......:..|:    :|..|
Human   609 ECGAFS-----------KPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPND------ 656

  Fly   500 GAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLI-- 562
               ..|.:..|..|.|...||:           .:.|:|   .|....|::..|:...:|..:
Human   657 ---GWAESEVPPSPTPHSALGL-----------GLEDYS---HSSGVDSAVYFPDQHINFRSVTP 704

  Fly   563 --QSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAA------PSLDEGHTFAHPAC 619
              |..:.||.:::|.|.|                 .|:..:||.|      ||.|.|.|..
Human   705 ARQPESINLKASKSMDLV-----------------PDESKVHSLAGQKSESPSKDFGPTLG---- 748

  Fly   620 VPRKMRRSLALETPTTPHKLSAQV------FGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWA 678
                :::|.:||:..|   ..|:|      |.:|......|....:|.:     |.:|::.|...
Human   749 ----LKKSSSLESLQT---AVAEVRKNDLPFHRPRPHMVRGRGCNESFR-----AAIDKSYDGPE 801

  Fly   679 SLQNLHKSHKDRTSMSASSSSHCLLEAT---NSE-PDLGNRALPA-------------------- 719
            .::  .....|::|.|...:.:|  |:.   ||| .|:.|:|...
Human   802 EIE--ADGLSDKSSHSGQGALNC--ESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEK 862

  Fly   720 -----NASPFR----RAWG-----------------------QSSFRTPRSDKVAKEQQQLGQSS 752
                 |..|.|    :.:|                       ....|....:|:.:|::::|...
Human   863 KRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKH 927

  Fly   753 PVRR--------------TASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPS 803
            ...|              ..|:...|:|        :.|...:|..|.........|..:|:||.
Human   928 QELREKQARGLLDYATGAIGSVYDMDDD--------EMDPNYARVNHFREPCTSANVFRSPSPPR 984

  Fly   804 AITASVAAEG----AAQDH--------------------GCPSSWAGSFERMLQDAAGMQTFSEF 844
            |.......:|    ..:||                    |.|:  .||.:|:           :.
Human   985 AGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPT--GGSTDRI-----------QK 1036

  Fly   845 LKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDP-------VNVDSQARSLT 902
            |:||      |:....|.:.|.|.:..| |:..|.....:.....|.       ..::.|..||.
Human  1037 LRKE------YYQARREGFPLYEDDEGR-ARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLP 1094

  Fly   903 EEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNF 967
            ....||  |..:.||..:                .||        |.:.|||
Human  1095 RGGPAD--PVDYLPAAPR----------------GLY--------KERELPY------------- 1120

  Fly   968 HLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADM---QHALMPAPPVPQN 1024
            :.||.                   |.|....|..|.....:||:   ||  .|.||.||:
Human  1121 YPGAH-------------------PMHPPKGSYPRPTELRVADLRYPQH--YPPPPAPQH 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	21/83 (25%)
		PTB_RGS12	251..391	CDD:269984	25/139 (18%)
		RGS_R12-like	828..941	CDD:188661	22/119 (18%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873
		PDZ_signaling	209..296	CDD:238492
		PDZ_signaling	395..475	CDD:238492	26/106 (25%)
		PDZ_signaling	509..597	CDD:238492	25/161 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810