DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Il16

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_006229550.1 Gene:Il16 / 116996 RGDID:1583872 Length:1425 Species:Rattus norvegicus


Alignment Length:1607 Identity:306/1607 - (19%)
Similarity:478/1607 - (29%) Gaps:614/1607 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 HHHPPLPITGASGST-------------AVGTGAAAAEDASPAANSGPAPISTSTTPSGSNS--- 51
            |.|...|:.|..|:.             |..|.||||:.:|...:. |.|........|..|   
  Rat    39 HIHRRTPLLGCQGTAPPPCCSWHLLPGQANRTHAAAAKPSSSTTHR-PRPGEQERKKRGLTSSLR 102

  Fly    52 -QQHQRRRKKRANYNYNGIRTVEVRRGYNGFGFTISGQQPCRLSCII--------SSSPAE---- 103
             :.|....|.|.:..:..|..                      |.|:        ||||.|    
  Rat   103 MEPHSHSGKSRKSTKFRSISR----------------------SLILCNAKTSDDSSSPDEKYPD 145

  Fly   104 --QAGL---RSGDF-----LISVNGLNVSKLP------HETVVQLIGNSFGS-IRMQIAENYYSD 151
              :..|   :.|.|     |...:...:|.:|      ....:|..|:..|. .|........|.
  Rat   146 PFETSLCQDKEGFFHSSMQLADTSEAGLSNIPDLALASEAAQLQAAGSDRGKHCRKMFFLKESST 210

  Fly   152 SSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVE---PHKSKSSP--- 210
            :|.:|.|     |:..|.|    ..||..|| .|:...|....:||..|.|   |...||:.   
  Rat   211 TSSKEKA-----GKSEAQS----SNFLFPKA-CHQRTRSNSTSVNPYSAREMDFPMTKKSAAPTD 265

  Fly   211 -----------------DHP---TLKPVLEDPPLTANLS-----------KAADVANVSAM---- 240
                             |:|   |.:|       |.:||           :|:.::|:..|    
  Rat   266 RQPYSLCSNRKSLSQQLDYPVSGTARP-------TRSLSTAQLGQLSGGLQASVISNIVLMKGQA 323

  Fly   241 ------------------------VRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIR 281
                                    :.|.|:||.:.|:..|    .|:.:....|....|.:..::
  Rat   324 KGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEG----DEILELNGESIAGLTHQDALQ 384

  Fly   282 KLRQEKR---QPTIVLMCITPDSL----------SLQSSSGGVLATYSSARLNFVSSSSESENRF 333
            |.:|.|:   ..|:.....||.||          ||.||:.|   ...|:..:..|.:|.:.   
  Rat   385 KFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCG---AQDSSPFSLESPASPAS--- 443

  Fly   334 FGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISH-SC--HVFV----------IDTKL------I 379
               .....:...:|...:..||.....|..||.: .|  .||:          :|.:|      :
  Rat   444 ---TAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGVFIHTLSPGSVAHLDGRLRCGDEIV 505

  Fly   380 E------HAQHLQRAHEFRLQCTRDPISNLCLEFPNN-------SEYVVNLVRSMYTMRILPPAS 431
            |      |...|...:.....|...|:..:....|:.       .|.|...|..:..      ..
  Rat   506 EINDSPVHCMTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVEGVKF------GK 564

  Fly   432 RSHQADYEAGAGAAAAGGA------VAAAHSPQPSNHSEISTTTSNSD----SGIGFNNDCTNIS 486
            ..||...|......::...      ....||..|...::.....|:||    ||....:.|:   
  Rat   565 ERHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSSSDSSYMSGSPGGSPCS--- 626

  Fly   487 DRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLG-----IVGIPDNRLTVRAMPDHSALLRSPPA 546
                        |||......|..:..:|:.|.|     ..|:|..        .|.   .|||.
  Rat   627 ------------AGAELQPSEGEGSTHSPSLPPGEEQEPCPGVPSR--------PHQ---ESPPL 668

  Fly   547 SSSLRRPN-----LLASFN-LIQSPATNLTSTRSCDDVLNLFVDDS--PRTLAAVASMDDISLHS 603
            |.||.|.:     |..||. |::.|    |||:........|.:||  .:.|.....:.|.|.|:
  Rat   669 SESLERDSHPPLKLKNSFEILVRKP----TSTKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHT 729

  Fly   604 AAPSLDE--------------GHTFAHPACVP-------------RKMRRSLALETPTTPHK--- 638
            ......|              |.|....||.|             .:.|||.:.|||.:|.|   
  Rat   730 LPTCSQETRELLPLLLQEDTAGRTLCTAACCPGPAASTQTSSSTEGEPRRSASPETPASPGKHPL 794

  Fly   639 LSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLL 703
            |..|      :|....|::              .|.|.|..:.:..|:.  .:.:.:.:.||..|
  Rat   795 LKRQ------ARMDYSFDS--------------TTEDPWVRISDCIKNL--FSPIMSENHSHMPL 837

  Fly   704 ---------EATNSEPDLG-NRALPANASP--FRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRR 756
                     :.|...|:.| ::...||.:|  |:.|.|.:..:.|   .||.:.....||     
  Rat   838 QPNASLGEEDGTQGHPEGGLSKMDTANGAPRIFKSADGSTVKKGP---PVAPKPAWFRQS----- 894

  Fly   757 TASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCP 821
                                 ||..|:       :||:....|...|||..:    ..::|...|
  Rat   895 ---------------------LKGLRN-------RVPETRRAPEVASAIQTT----PVSRDASGP 927

  Fly   822 SSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADR------VAQAREIF 880
            .|.|.| ..:.|..:..:.|......:...:.:...........|..:.|.      .||..::.
  Rat   928 QSQASS-SSIRQRISSFENFGSSQLPDRGVQRLSLQPTSGETTRLPGKQDEGRFSGLPAQGTKVT 991

  Fly   881 AKHLAN----------NSS---DP----------------VNVDSQARSLTEEKLADAAPDIFAP 916
            |||...          |||   ||                ::.|...|.||.:......|....|
  Rat   992 AKHRQTEVEPPSTTFPNSSEVGDPDMSESPPPGQRPNPKALSPDPLLRLLTTQTEDTQGPGFKMP 1056

  Fly   917 AQK-QIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSAS 980
            :|: :.|.|.:..||:..:                        |||         ..|||...:|
  Rat  1057 SQRARSFPLTRTQSYETKL------------------------LDE---------KSSKLYSISS 1088

  Fly   981 NAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLH 1045
            .......||||                       .:|          :|||    |||  ::.:.
  Rat  1089 QLSSAVMKSLL-----------------------CLP----------SSAS----CGQ--ITCIP 1114

  Fly  1046 SSRSSLSS--FDAGTATG-GQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNL 1107
            ..|.|..|  .::..|.| |:..::::.:||....|.:.:..:  |.||||         |.|| 
  Rat  1115 KERVSPKSPCNNSAAAEGFGEAVASDTGFSLNLSELREYSEGL--TEPGET---------EDRN- 1167

  Fly  1108 VYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPI 1172
                              ...||  ||:                 .|||:.|  .::|.::|   
  Rat  1168 ------------------HCSSQ--AGQ-----------------SVISLLS--AEELKKLI--- 1190

  Fly  1173 LSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSD------FQVGGGSSMPPKQSK 1231
                    |:|:|:...|...:|           .:.:.:::.:      |.:.||:.:..|...
  Rat  1191 --------EEVRVLDEATLKQLD-----------SIHVTVLHKEEGAGLGFSLAGGADLENKVIT 1236

  Fly  1232 PMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDG 1296
            ..:..|.|             |||:....            .|.||..|                
  Rat  1237 VHRVFPNG-------------LASQEGTI------------QKGNEVLS---------------- 1260

  Fly  1297 GNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVK 1343
                      :..||...:..::..|..:...||::.:|...||.|:
  Rat  1261 ----------INGKSLKGATHNDALAILRQARDPRQAVIVTRKAIVE 1297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 18/104 (17%)
PTB_RGS12 251..391 CDD:269984 35/177 (20%)
RGS_R12-like 828..941 CDD:188661 25/148 (17%)
RGS12_RBD 1073..1145 CDD:176412 14/71 (20%)
RBD 1144..1213 CDD:128731 11/68 (16%)
Il16XP_006229550.1 PDZ_signaling 316..391 CDD:238492 12/78 (15%)
PDZ_signaling 454..536 CDD:238492 16/81 (20%)
PDZ_signaling 1207..1284 CDD:238492 16/127 (13%)
PDZ 1329..1413 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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