DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and Slc9a3r2

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_446263.2	Gene:	Slc9a3r2 / 116501	RGDID:	620380	Length:	337	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	78/310 - (25%)
Similarity:	121/310 - (39%)	Gaps:	81/310 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 RTVEVRRGYNGFGFTISGQQPCR---LSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQ 131
            |...:.||..|:||.:.|::..|   :..:...||||.|.||:||.|:.|||:||....|..|||
  Rat    10 RLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQ 74

  Fly   132 LIGNSFGSIRMQIAENYYSD-------SSDEENAHATL----------------------RGQLL 167
            .|....|..::.:.:....:       :..||.||..|                      .||
  Rat    75 RIKAVEGQTQLLVVDKETDEELCRRQLTCTEEMAHRGLPPAHNPWEPKPDWACSGSLGSDTGQ-- 137

  Fly   168 AASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLS--K 230
             ..:...||.|  :.:|..||..||     ......|..||.|.. .::.|  ||...|:||  :
  Rat   138 -KDVNGPPREL--RPRLCHLRRGPQ-----GYGFNLHSDKSRPGQ-YIRSV--DPGSPASLSGLR 191

  Fly   231 AAD--------------VANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIR 281
            |.|              .|.|.|.::|...   |.|::|     :: |:...|..:|:.|.:
  Rat   192 AQDRLIEVNGQNVEGLRHAEVVARIKAQED---EARLLV-----VD-PETDEHFKRLRVVPT--- 244

  Fly   282 KLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESEN 331
            :...|...|:.|     .:..||...:||   :..|:|.:...|..::|:
  Rat   245 EDHVEGPLPSPV-----TNGTSLAQLNGG---SVCSSRSDLPGSEKDNED 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	29/77 (38%)
		PTB_RGS12	251..391	CDD:269984	17/81 (21%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Slc9a3r2	NP_446263.2	PDZ_signaling	9..88	CDD:238492	29/77 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		3/21 (14%)
		PDZ_signaling	149..228	CDD:238492	24/94 (26%)
		EBP50_C	232..337	CDD:401087	14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..337		11/49 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900