DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Rgs14

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_446216.1	Gene:	Rgs14 / 114705	RGDID:	620003	Length:	544	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	179/557 - (32%)
Similarity:	269/557 - (48%)	Gaps:	97/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   775 DSDLKS-SRSQHQ-------LSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERM 831
            |.:|.| |.||.|       ||:..:|   :.|:.|           .:.|....:|||.||||:
  Rat    21 DGELTSTSGSQAQGEGRGSSLSIHSLP---SGPSSP-----------FSTDEQPVASWAQSFERL 71

  Fly   832 LQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLL-ESEADRVAQ-AREIFAKHLANNSSDPVNV 894
            |||..|:..|:|||||||||||:.||.||||::.: .|:..::|| |..|:.:.|::.:..|||:
  Rat    72 LQDPRGLAYFTEFLKKEFSAENVTFWQACERFQQIPASDTKQLAQEAHNIYHEFLSSQALSPVNI 136

  Fly   895 DSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDL 959
            |.|| .|:||.||...||:|...|.|||:|||||||.||::|.||:.|:.||.:.:||...|
  Rat   137 DRQA-WLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLREPG--- 197

  Fly   960 DELLKTNFHLGA------FSKLKKSAS---NAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHAL 1015
                  :.|||:      ..|||...|   ..|:..:..|.......:|..|:
  Rat   198 ------SSHLGSPDTARKKPKLKPGKSLPLGVEELGQLPLAEGRPLRKSFRRE------------ 244

  Fly  1016 MPAPPV-------PQNAPLTSASLKL--VCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVY 1071
            ||...|       .|.:..:||||.|  :...:|.|:.|  |.||.|        |:|.|.....
  Rat   245 MPGGAVNSALRRESQGSLNSSASLDLGFLAFVSSKSESH--RKSLGS--------GEGESESRPG 299

  Fly  1072 SLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQG-STKSIDVQQPSQILAGK 1135
            ..|.|.|.||..::...|||.|:.:::..:.|||.|..|...:...| ..|::.:.|...:||.:
  Rat   300 KYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGKEQKALVLDQDCTVLADQ 364

  Fly  1136 EVVIERRVAFKLDLPD-PKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQP 1199
            ||.:|.|:.|:|:|.. .:|:.:.:||.|:|.|.::|||:|:...::||.:.....:..:||...
  Rat   365 EVRLENRITFQLELVGLERVVRISAKPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQLVDLENL 429

  Fly  1200 VTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQ---GHLDELTNKVFNELLASKADAAA 1261
            |:....|.| ::....|.:....||:||.:|:...|..|   .||..|::.:      |..||:.
  Rat   430 VSSVASQTL-VLDTLPDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSL------SVEDASG 487

  Fly  1262 SEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGN 1298
            |...|  ..|.::         .|.|.:.|.|..|.:
  Rat   488 STGKR--QTCDIE---------GLVELLNRVQSSGAH 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	61/114 (54%)
		RGS12_RBD	1073..1145	CDD:176412	23/72 (32%)
		RBD	1144..1213	CDD:128731	20/69 (29%)
Rgs14	NP_446216.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..59		13/51 (25%)
		RGS_RGS14	58..186	CDD:188697	66/128 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..220		10/37 (27%)
		Necessary for interaction with RABGEF1. /evidence=ECO:0000250	297..424		38/126 (30%)
		RGS12_RBD	301..374	CDD:176412	23/72 (32%)
		UBQ	382..443	CDD:294102	17/61 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..493		15/51 (29%)
		GoLoco	497..519	CDD:214645	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5761
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144440at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45478
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880