DRSC/TRiP Functional Genomics Resources

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Protein Alignment loco and RGS14

DIOPT Version :10

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_047272594.1 Gene:RGS14 / 10636 HGNCID:9996 Length:619 Species:Homo sapiens


Alignment Length:686 Identity:185/686 - (26%)
Similarity:273/686 - (39%) Gaps:195/686 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   775 DSDLKSSRSQH--------QLSLLQVPKVLTTPAP----PSAITASVAAEGAAQDHGCPSSWAGS 827
            |.:|.|:....        .||:..:|...::|.|    |.|                  |||.|
Human    21 DGELSSTTGPQGQGEGRGSSLSIHSLPSGPSSPFPTEEQPVA------------------SWALS 67

  Fly   828 FERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLL-ESEADRVAQ-AREIFAKHLANNSSD 890
            |||:|||..|:..|:|||||||||||:.||.||||::.: .|:..::|| ||.|:.:.|::.:..
Human    68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALS 132

  Fly   891 PVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYS 955
            |||:|.|| .|.||.||:..||:|...|.|||:|||||||.||::|.||:.|:.||.:.:||...
Human   133 PVNIDRQA-WLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLREP 196

  Fly   956 GLDLDELLKTNFHLGAFSKLKK--SASNAEDRRRKSLLPWHRKTRSKSRDRT---EIMADMQHAL 1015
            |         :..||:....:|  .......|.|.|..|..|...|..|..:   .....:..:.
Human   197 G---------SSRLGSPDATRKVRGTGRGTGRGRGSCGPRARGDASGCRSASLCPRSACGLGPSP 252

  Fly  1016 MPAPPVPQNAPLTSASLKLVCGQNSLSDL-------------------------------HSSRS 1049
            :||||:....|.......|..|...|..|                               ..|.:
Human   253 VPAPPLYPQKPKLKPGKSLPLGVEELGQLPPVEGPGGRPLRKSFRRELGGTANAALRRESQGSLN 317

  Fly  1050 SLSSFDAG----------------TATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELV 1098
            |.:|.|.|                .:|.|:..|....|  |.|.|.||..::...|||.|:.:::
Human   318 SSASLDLGFLAFVSSKSESHRKSLGSTEGESESRPGKY--CCVYLPDGTASLALARPGLTIRDML 380

  Fly  1099 ERLLEKRNLVYPYYDIVFQGS-TKSIDVQQPSQILAGKEVVIERRVAFKLDLPD-PKVISVKSKP 1161
            ..:.|||.|..|...:...|: .|::.:.|...:||.:||.:|.|:.|:|:|.. .:|:.:.:||
Human   381 AGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFELELTALERVVRISAKP 445

  Fly  1162 KKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMP 1226
            .|:|.|.::|||.|:.....:|.:.....:.|:||.:.|:....|||                  
Human   446 TKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRL------------------ 492

  Fly  1227 PKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRR 1291
                         .||.|                                               
Human   493 -------------VLDTL----------------------------------------------- 497

  Fly  1292 QQRDGGNIPASKLPKLKKKSTSSSQ----QSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAE 1352
                    |..|:.|.:.||...||    ::::.||....|.|...:.....|..|.|..:    
Human   498 --------PGVKISKARDKSPCRSQGCPPRTQDKATHPPPASPSSLVKVPSSATGKRQTCD---- 550

  Fly  1353 HQDELLEGLKRAQLARLEDQRGTEINFD--LPDFLK 1386
             .:.|:|.|.|.|.:...||||.....|  ||:||:
Human   551 -IEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFLQ 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_RGS12-like 70..145 CDD:467194
PTB_RGS12 251..391 CDD:269984
RGS_R12-like 828..941 CDD:188661 62/114 (54%)
RBD1_RGS12_like 1072..1141 CDD:340515 21/69 (30%)
RBD2_RGS12_like 1142..1212 CDD:340587 22/70 (31%)
GoLoco 1354..1375 CDD:214645 8/20 (40%)
RGS14XP_047272594.1 RGS_RGS14 58..186 CDD:188697 69/146 (47%)
RBD1_RGS14 354..424 CDD:340657 22/71 (31%)
RBD2_RGS14 425..496 CDD:340659 23/101 (23%)
GoLoco 552..573 CDD:460481 9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

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