DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and RGS14

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_024310096.1	Gene:	RGS14 / 10636	HGNCID:	9996	Length:	593	Species:	Homo sapiens

Alignment Length:	660	Identity:	190/660 - (28%)
Similarity:	282/660 - (42%)	Gaps:	169/660 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   775 DSDLKSSRSQH--------QLSLLQVPKVLTTPAP----PSAITASVAAEGAAQDHGCPSSWAGS 827
            |.:|.|:....        .||:..:|...::|.|    |.|                  |||.|
Human    21 DGELSSTTGPQGQGEGRGSSLSIHSLPSGPSSPFPTEEQPVA------------------SWALS 67

  Fly   828 FERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLL-ESEADRVAQ-AREIFAKHLANNSSD 890
            |||:|||..|:..|:|||||||||||:.||.||||::.: .|:..::|| ||.|:.:.|::.:..
Human    68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALS 132

  Fly   891 PVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYS 955
            |||:|.|| .|.||.||:..||:|...|.|||:|||||||.||::|.||:.|:.||.:.:||...
Human   133 PVNIDRQA-WLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLREP 196

  Fly   956 GLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPP 1020
            |                    .|...:.|..||         :.|.:....:...::. |...||
Human   197 G--------------------SSRLGSPDATRK---------KPKLKPGKSLPLGVEE-LGQLPP 231

  Fly  1021 V--PQNAPL-------------------------TSASLKL--VCGQNSLSDLHSSRSSLSSFDA 1056
            |  |...||                         :||||.|  :...:|.|:.|  |.||.|
Human   232 VEGPGGRPLRKSFRRELGGTANAALRRESQGSLNSSASLDLGFLAFVSSKSESH--RKSLGS--- 291

  Fly  1057 GTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGS-T 1120
               |.|:..|....|  |.|.|.||..::...|||.|:.:::..:.|||.|..|...:...|: .
Human   292 ---TEGESESRPGKY--CCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQ 351

  Fly  1121 KSIDVQQPSQILAGKEVVIERRVAFKLDLPD-PKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQ 1184
            |::.:.|...:||.:||.:|.|:.|:|:|.. .:|:.:.:||.|:|.|.::|||.|:.....:|.
Human   352 KALVLDQDCTVLADQEVRLENRITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVV 416

  Fly  1185 VIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVF 1249
            :.....:.|:||.:.|:....|||                                       |.
Human   417 LHRPGEKQPLDLGKLVSSVAAQRL---------------------------------------VL 442

  Fly  1250 NELLASKADAAASEKSRPVDLCSMKSNEAPSETSSL-FERMRRQQRDGGNIPASKLPKLKKKSTS 1313
            :.|...|.     .|:|....|..:.:|....:|:| |     ...|.|:.|        |.|..
Human   443 DTLPGVKI-----SKARDKSPCRSQVSERRVASSTLCF-----SPPDFGSDP--------KFSQG 489

  Fly  1314 SSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEIN 1378
            ...::::.||....|.|...:.....|..|.|..:     .:.|:|.|.|.|.:...||||....
Human   490 CPPRTQDKATHPPPASPSSLVKVPSSATGKRQTCD-----IEGLVELLNRVQSSGAHDQRGLLRK 549

  Fly  1379 FD--LPDFLK 1386
            .|  ||:||:
Human   550 EDLVLPEFLQ 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	62/114 (54%)
		RGS12_RBD	1073..1145	CDD:176412	23/72 (32%)
		RBD	1144..1213	CDD:128731	21/69 (30%)
RGS14	XP_024310096.1	RGS_RGS14	58..186	CDD:188697	69/146 (47%)
		RGS12_us1	189..273	CDD:318754	19/113 (17%)
		RGS12_RBD	303..376	CDD:176412	24/74 (32%)
		RBD	376..445	CDD:128731	22/107 (21%)
		GoLoco	525..547	CDD:214645	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5760
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144440at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880