Protein Alignment loco and PATJ

DIOPT Version :9

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_011538764.1
• Gene: PATJ / 10207
• HGNCID: 28881
• Length: 1937
• Species: Homo sapiens
• Alignment Length: 1621
• Identity: 279/1621 - (17%)
• Similarity: 495/1621 - (30%)
• Gaps: 623/1621 - (38%)

  Fly    69 IRTVEVRRGYNGFGFTISGQQPCR--LSCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPHETVV 130
            :..||:....:|.||.|.|.:...  :..|:....|::.| |::||.::.:.|.||..:..|.|.
Human   246 VEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310

  Fly   131 QLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKL 195
            |::.|...|:||.:|.:...|.|....|.|.|
Human   311 QVLRNCGNSVRMLVARDPAGDISVTPPAPAAL--------------------------------- 342

  Fly   196 NPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGT 260
              |.|:....||.             |...::|.:..:|    .:||..|. :|..| ||||:||
Human   343 --PVALPTVASKG-------------PGSDSSLFETYNV----ELVRKDGQ-SLGIR-IVGYVGT 386

  Fly   261 IEMPK-------------------QISHSSKLQTV----------RSCIRKLRQEKRQPTIVLM- 295
            ....:                   .|..:.|:..|          ...:..||...:...:.|:
Human   387 SHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451

  Fly   296 ---CITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSA 357
               ..:...|...|..|.|:.......| |::.:.|:|....|      .:.:|:|.
Human   452 RKTSSSTSPLEPPSDRGTVVEPLKPPAL-FLTGAVETETNVDG------EDEEIKER-------- 501

  Fly   358 AAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMY 422
                            |||...::.|.|::..                :.|::.|   |.::|.:
Human   502 ----------------IDTLKNDNIQALEKLE----------------KVPDSPE---NELKSRW 531

  Fly   423 TMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISD 487
            . .:|.|       |||          .:.|....|.::.:|:...:
Human   532 E-NLLGP-------DYE----------VMVATLDTQIADDAELQKYS------------------ 560

  Fly   488 RILVVDFLAAGAGA---------AAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRS 543
            ::|.:..|..|...         ::....|      |...||::...|..|.|..|..:....|.
Human   561 KLLPIHTLRLGVEVDSFDGHHYISSIVSGG------PVDTLGLLQPEDELLEVNGMQLYGKSRRE 619

  Fly   544 PPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMD-DISLHSAAPS 607
              |.|.|:.         :..|.|.:...|..||..:  ||:..||..::...: |.::......
Human   620 --AVSFLKE---------VPPPFTLVCCRRLFDDEAS--VDEPRRTETSLPETEVDHNMDVNTEE 671

  Fly   608 LDEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAID------------S 660
            .|:|               .|||.:|..  |:...|....|    |||..:|            .
Human   672 DDDG---------------ELALWSPEV--KIVELVKDCKG----LGFSILDYQDPLDPTRSVIV 715

  Fly   661 VQS--------------------SVSGACMDQTMDTWA--------------------------- 678
            ::|                    ||:..|:|.|....|
Human   716 IRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEE 780

  Fly   679 SLQNLH-KSHKDRTSMSAS---SSSHCLLEATN-------------SEP--DLGN--RALPANAS 722
            |...|| .|::|:|..|.:   .:|..:|||..             .||  |||.  .:......
Human   781 SCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIE 845

  Fly   723 PFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQL 787
            ..:.||....|.|||..::.:|::.|..            .:.::|       .|...|...:.|
Human   846 QSKEAWEMHEFLTPRLQEMDEEREILVD------------EEYELY-------QDPSPSMELYPL 891

  Fly   788 SLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAE 852
            |.:|.    .||.|                                                |..
Human   892 SHIQE----ATPVP------------------------------------------------SVN 904

  Fly   853 NIYFWTACERYRLLE----SEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDI 913
            .::|.|     :.|.    ||:......|.::::........|.||      :.|..:.::.|.:
Human   905 ELHFGT-----QWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENV------MKENFVMESLPSV 958

  Fly   914 FAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKS 978
              |:.:......:||..:                          :|:.|.||:..||......:.
Human   959 --PSTEGNSQQGRFDDLE--------------------------NLNSLAKTSLDLGMIPNDVQG 995

  Fly   979 ASNAED------RRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCG 1037
            .|...|      ||.:..||.:                 ||                .:.:::..
Human   996 PSLLIDLPVVAQRREQEDLPLY-----------------QH----------------QATRVISK 1027

  Fly  1038 QNSLSDLHSSRSSLSSFDAGTATGGQGASTES--------VYSLCR-------VILTDGATTIVQ 1087
            .::.:.:.|||.:..:.:......|:|..|.:        :..:.|       :.:..|.|.|.:
Human  1028 ASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKR 1092

  Fly  1088 TRPGETV-GELVERLLE-----KRNLVYPYYDIVFQGSTKSIDVQQPSQI-------LAGKEVVI 1139
            .:.||.: |..::::||     |.|.:.....|:   ....:|:|..|..       .||..||.
Human  1093 LKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL---EVSGVDLQNASHSEAVEAIKNAGNPVVF 1154

  Fly  1140 ERRVAFKLDLPDPKVISVKSKPK--KQLHEVIRPILSKYNYKMEQVQVIMRDTQVP--------- 1193
                         .|.|:.|.|:  ..:|.....|....|...::.:...:.|..|
Human  1155 -------------IVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206

  Fly  1194 -----IDLNQPVTMADGQRLR-----------IVMVNSDFQVGGGSSMPPKQSKPMKPL------ 1236
                 .|.|:.......|::|           |:.:..| :.|.|.|:...:.:....:
Human  1207 ALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKD-KNGLGLSLAGNKDRSRMSIFVVGIN 1270

  Fly  1237 PQGHL---------DELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQ 1292
            |:|..         |||. ::.|::|..::...||        ..:|:  |||:...:|.|
Human  1271 PEGPAAADGRMRIGDELL-EINNQILYGRSHQNAS--------AIIKT--APSKVKLVFIR---- 1320

  Fly  1293 QRDGGN--------IPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTER 1349
            ..|..|        :|:|....::.:|.:....|||..:              ::.|:| |:.|.
Human  1321 NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGS--------------VEVGIK-QLPES 1370

  Fly  1350 VAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRKVRASLSPVSKVPAT 1414
            .:...:::.:.:.:..:|  :.|:..|..   ||         .|||::::        .|.|.
Human  1371 ESFKLEDMSQVIGQGMVA--DQQKALEYP---PD---------NAVSQMKQ--------QKYPT- 1412

  Fly  1415 PTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTEFAKAPPPLPPKPKVLPIKP 1475
                     ::|.:..:.|::|.......:.|.       |.:.....||...|...||.|
Human  1413 ---------KVSFSSQEIPLAPASSYHSTDADF-------TGYGGFQAPLSVDPATCPIVP 1457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	23/78 (29%)
		PTB_RGS12	251..391	CDD:269984	29/172 (17%)
		RGS_R12-like	828..941	CDD:188661	15/116 (13%)
		RGS12_RBD	1073..1145	CDD:176412	19/91 (21%)
		RBD	1144..1213	CDD:128731	14/95 (15%)
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	246..325	CDD:238492	23/78 (29%)
		PDZ_signaling	366..450	CDD:238492	17/89 (19%)
		PDZ_signaling	570..634	CDD:238492	15/80 (19%)
		PDZ	683..772	CDD:214570	14/94 (15%)
		PDZ_signaling	1066..1157	CDD:238492	19/106 (18%)
		PDZ	1236..1321	CDD:214570	20/100 (20%)
		PDZ	1459..1574	CDD:214570
		PDZ_signaling	1586..1666	CDD:238492
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900