DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and USH1C

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_016872564.1	Gene:	USH1C / 10083	HGNCID:	12597	Length:	956	Species:	Homo sapiens

Alignment Length:	459	Identity:	81/459 - (17%)
Similarity:	150/459 - (32%)	Gaps:	164/459 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1164 QLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDL----NQPVTMADGQRLRIVMVNSDFQVGGGSS 1224
            |:.||.....|..::| |.|.|:.....:.|.:    .:.:.|.|.:||              :.
Human   257 QIVEVNGVDFSNLDHK-EAVNVLKSSRSLTISIVAAAGRELFMTDRERL--------------AE 306

  Fly  1225 MPPKQSKPMKPLPQGHLDELTNKVFNEL----------LASKADAAASEKSRPVDLCSMKSNEAP 1279
            ...::.:..:.|.|..|...:||:..|.          :|.|| |..:|:.|       |..|..
Human   307 ARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKA-AEENERYR-------KEMEQI 363

  Fly  1280 SETSSLFERMRRQQRDGGN----------------IPA-------------SKLPKLKKKSTSSS 1315
            .|....|:  ::.:.|.|:                :|.             .|.|.::||  ...
Human   364 VEEEEKFK--KQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKK--GKD 424

  Fly  1316 QQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEINFD 1380
            ::..:..:.|.:...||          :|:..:::.:.::|:||..|:.::.||    ..|::..
Human   425 KKKAKYGSLQDLRKNKK----------ELEFEQKLYKEKEEMLEKEKQLKINRL----AQEVSET 475

  Fly  1381 LPDFLKNKENLSAAV-----SKLRKVRASLSPVSKVPATPTEIPQPAPRLS-------------- 1426
            ..:.|:..|.:...|     ::|.::.::.:.:|::...|   |.|.|.:|
Human   476 EREDLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGP---PPPPPSVSPLAPPLRRFAGGLH 537

  Fly  1427 ------------------ITRSQQPVSPMKVDQEPETDLPA----------ATQDQTEFAKAPP- 1462
                              .|.|..||.|......|...:||          :........:.||
Human   538 LHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPP 602

  Fly  1463 -PLPPKPKV-----LPIKP-----------------------SNWGVAQPTGNYCNKYSPSKQVP 1498
             |:||.|.|     .|.:|                       .:|.....:|...|...|.:..|
Human   603 IPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFP 667

  Fly  1499 TSPK 1502
            .:||
Human   668 PTPK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731	13/52 (25%)
USH1C	XP_016872564.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900