DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and rgs14

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_004912911.2	Gene:	rgs14 / 100490892	XenbaseID:	XB-GENE-5831784	Length:	731	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	201/743 - (27%)
Similarity:	317/743 - (42%)	Gaps:	154/743 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 SQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKK 847
            |.|.|:.|           ||.....:|.|.:.      :|||.||||:|||..|::.|:|||||
Frog    55 SNHSLNSL-----------PSVQIGGLAPEKSV------ASWAVSFERLLQDPLGVEYFTEFLKK 102

  Fly   848 EFSAENIYFWTACERYRLLES-EADRVAQ-AREIFAKHLANNSSDPVNVDSQARSLTEEKLADAA 910
            |:||||||||.|||:::.:.: :::::.| :..|:.::|:::|..|||:|.|| .:||:.|...:
Frog   103 EYSAENIYFWKACEKFQSISNDDSEKLLQESHRIYNEYLSSSSLCPVNIDQQA-LITEDMLETPS 166

  Fly   911 PDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNF-------- 967
            ||:|...|.|||:|||||||.||::|.||:.|:.||.:.:|||          ..||
Frog   167 PDLFKAQQLQIFNLMKFDSYARFVKSSLYQECMLAEVEGRPLP----------NLNFSPTNPVAG 221

  Fly   968 ---HL-GAFSKLKKSASN--------------AEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHA 1014
               |. ||..|.|..|..              |:...|:|.....||..||.        |:.
Frog   222 CSAHASGAVKKKKLRAGKSLPVGVEGAGIETVADKSHRRSFKKKDRKGHSKE--------DLD-- 276

  Fly  1015 LMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSSL---SSFDAG---TATG---GQGASTESV 1070
                                   .|.||....||.||   :|.:.|   |.|.   .:||||.:.
Frog   277 -----------------------SNGLSSRRESRISLNSNTSLELGLNSTPTSKSENEGASTGNA 318

  Fly  1071 --------YSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGS-TKSIDVQ 1126
                    ...|.|.|.||..::...:.|.|:.:::..:.|||........:...|: .|.:.:.
Frog   319 DPEADSKSIKYCCVYLPDGTASLTAVKQGLTIRDMLAGVCEKRGYCLTDVKVFLVGNEQKPLALD 383

  Fly  1127 QPSQILAGKEVVIERRVAFKLDL-PDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDT 1190
            |...:|..:||.:|.|::|.|.: |..|.:.:.|||.|.:.|.:.|||.||..:..|..|:.:..
Frog   384 QECLVLTEQEVRLENRISFDLQMNPINKSVRIVSKPTKTIGEALLPILKKYGLENHQHIVLTKVG 448

  Fly  1191 QV-PIDLNQPVTMADGQRLRIVMVN-SDFQ--VGGGSSMPPKQSKPMKPLPQGHLDE---LTNKV 1248
            |. .:|....|....||:|.:.:|| ||.:  ||     |..:....|...:.|.::   |..:.
Frog   449 QSHALDHKSSVNEVAGQKLELEVVNFSDSKKVVG-----PTAEHHTKKDSTKEHREDKDILMTET 508

  Fly  1249 FNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTS 1313
            :|.:           |..|.::..:.|..:.:|......:...:...|.:.|.:::|..|.|..:
Frog   509 YNRV-----------KKEPQNVNQVSSEHSHAEAPHGKHKPHAETPHGKHKPHAEVPHGKHKPHA 562

  Fly  1314 SSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDEL----LEG----LKRAQLARLE 1370
            .:...:.....:|.....||.........|........:|:..|    :||    |.:.|.:|.:
Frog   563 EAPHGKHKPHAEAPHGKHKPHAEAPHGKHKPHAEASHGKHKPHLHKHDIEGLVELLNKVQSSRAD 627

  Fly  1371 DQRGTEINFD--LPDFLK---NKENLSAAVSKLRKVRASLSPVSKVP-------ATPTEIPQPAP 1423
            ||||.....|  ||||||   :||.....::...|   |....:|||       |:.:.......
Frog   628 DQRGLLCKEDLVLPDFLKVPTDKECNHCCMTSADK---SAVITTKVPGCLDLSQASESYCEHNCS 689

  Fly  1424 RLSITRSQQPVSPMKVDQEPETDLPAAT 1451
            ..|:...:...:.:...:|||..:..:|
Frog   690 TNSLCLEESQANTVNNGKEPEIIISDST 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	57/114 (50%)
		RGS12_RBD	1073..1145	CDD:176412	18/72 (25%)
		RBD	1144..1213	CDD:128731	22/70 (31%)
rgs14	XP_004912911.2	RGS_RGS14	73..201	CDD:188697	63/134 (47%)
		RGS12_us1	203..299	CDD:406910	27/138 (20%)
		RBD1_RGS14	328..398	CDD:340657	16/69 (23%)
		Ubiquitin_like_fold	399..472	CDD:421700	23/72 (32%)
		PspC_subgroup_2	<421..>608	CDD:411408	41/202 (20%)
		GoLoco	611..633	CDD:214645	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5727
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144440at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48556
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010