DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and pdzd7a

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001177686.1	Gene:	pdzd7a / 100332580	ZFINID:	ZDB-GENE-090313-191	Length:	954	Species:	Danio rerio

Alignment Length:	883	Identity:	168/883 - (19%)
Similarity:	286/883 - (32%)	Gaps:	308/883 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 SMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPH----KLSAQVFGQPGSRHSLGF 655
            |.:||: ||.|..:.:.||  |.....::..|..|.:.....:    ||:..  |||.|  |.|.
Zfish   250 SFEDIT-HSNAVEVLKSHT--HVMLTIKEAGRYPAYKEMVAEYSWLNKLANG--GQPSS--SQGS 307

  Fly   656 EAIDSVQSSVSGACMDQTMDTWASLQNLHK----------------SHKDRTSMSASSSSHCLLE 704
            ::..|..|..||..:       :||..|.:                |.:||:...:|......::
Zfish   308 DSYSSTSSLSSGTPV-------SSLSGLSQVTFPPAFGSEMVDVCISTEDRSRRPSSERIETAIQ 365

  Fly   705 ATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYI 769
            ....:||..:|.....::...|..|::         |..:...:.:.:...||.:.:|.|.:
Zfish   366 TDPQDPDTISRTSRVMSTETSRMVGET---------VLLKDTVIRRGTAHSRTRTFSAGDKE--- 418

  Fly   770 KTLMLDSDLKSSRSQHQLSLLQVPK---VLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERM 831
               .|||                ||   ::....|..||..|       |.|
Zfish   419 ---TLDS----------------PKTAVLMALSKPRKAIRRS-------QSH------------- 444

  Fly   832 LQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQA-REIFAKHLANNSSDPVNVD 895
                   .|.||            ||.|.||...|.....|..|. ::...||...      .|:
Zfish   445 -------ITVSE------------FWFATERASCLCGCTSRSRQEDKQKKRKHQKG------KVE 484

  Fly   896 SQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLD 960
            ::..:|...|               .|..:.|.|.:|..||                  |..|..
Zfish   485 TEGSTLQRSK---------------TFVTLPFKSGRRRERS------------------SSRDRK 516

  Fly   961 ELLKTNFHLGAFSKLKKSASNAEDRRRK----SLLPWHRKTRSKSRDRTEIMADMQHALMPAPPV 1021
            :..:.:.|.|. ||..|...|...:.|.    :||...|:||:..|:::              |:
Zfish   517 DTGREDGHKGR-SKSPKHLDNEPGKERGRPIINLLSSPRETRAGLREQS--------------PM 566

  Fly  1022 PQNAPLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIV 1086
            |  :|.|.|.|:.|           :|..|:..:..           :|...|:..|.|   .:|
Zfish   567 P--SPETMALLEDV-----------ARKLLNEDEVA-----------AVMRHCKRFLVD---RVV 604

  Fly  1087 Q--TRPGETVGELVERLLEKR---------------NLVYPY----YDIVFQGSTKSIDVQQPSQ 1130
            :  .||...:.:..|:||..|               ::|.|:    |||:...|.:|..::.|..
Zfish   605 EDLVRPLLAILDKPEKLLLLREVRMIIPATDLGRFDSMVLPFELEAYDILKSRSVRSPVLRSPRH 669

  Fly  1131 ILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILS-KYNYKMEQVQVIMRDTQVPI 1194
                                       ...|::.|   |.||.. :..:.::.||.:.|:.|:..
Zfish   670 ---------------------------GGTPRRHL---ITPIPDYRGGFHLQPVQDLERERQLIE 704

  Fly  1195 DLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDE-LTNKVFNELLASKAD 1258
            ||         :|:|:..:.:      |...||:...|:..:|   :|. :|:.:.|..| |.|.
Zfish   705 DL---------ERMRLAGLPT------GRLPPPRAFTPLLDVP---VDTYITDSLRNRSL-SPAR 750

  Fly  1259 AAASEKSRPVDLCSMKSNEAP-------------SETSSLFERMRRQQRDGGNIPASKL--PKLK 1308
            :..|....|..  :.::..:|             |...|:.||.|...|:|..:...|.  .|..
Zfish   751 SGFSHSESPYS--TERTGRSPLRRDNGFPHDSLSSRGDSVPERGRSPYRNGHRMKTDKSLNGKEV 813

  Fly  1309 KKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQR 1373
            |.:..|:.:......:|..|...:                   :|..|.:.|       ..:.|.
Zfish   814 KYTVMSAHRRSRTPLSQVFAPSPE-------------------QHWKEPVNG-------HSDSQD 852

  Fly  1374 GTEINFDLPDFLKNKENLSAAVSKLRKVRASLSPVSKV 1411
            .||.::.|.....:|...|..:|....:.:.:.|:.|:
Zfish   853 RTEQDYVLTTVTISKTKQSLGISISGGIESKVQPMVKI 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	22/113 (19%)
		RGS12_RBD	1073..1145	CDD:176412	18/92 (20%)
		RBD	1144..1213	CDD:128731	13/69 (19%)
pdzd7a	NP_001177686.1	PDZ_signaling	69..149	CDD:238492
		PDZ_signaling	194..274	CDD:238492	9/26 (35%)
		HN_PDZD7_like	568..645	CDD:259824	19/101 (19%)
		PDZ_signaling	860..948	CDD:238492	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910