DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and rgs14b

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_017208541.1	Gene:	rgs14b / 100003648	ZFINID:	ZDB-GENE-101006-2	Length:	573	Species:	Danio rerio

Alignment Length:	649	Identity:	174/649 - (26%)
Similarity:	266/649 - (40%)	Gaps:	168/649 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 SMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSS 823
            ::..||.::   .:|.|....:..|....||..||              |..:.|..|    .:|
Zfish    16 TLTVSDGEL---NVMSDEHAATHHSSSNSSLPTVP--------------SEGSRGVGQ----VAS 59

  Fly   824 WAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLES-EADRV-AQAREIFAKHLAN 886
            ||.||||:|:|..|:..|:.|||.|.|||||.||:|||::|.:.. :.::: .:|..|:...|::
Zfish    60 WAVSFERLLEDPVGVCYFTAFLKSEVSAENILFWSACEKFRKIPGHQTEQLKREALSIYNTFLSS 124

  Fly   887 NSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQP 951
            |::.|:|:|.:.| :.|:.:.:...|||..||:|||.|||||||.||:||.||:||:.|..:.:|
Zfish   125 NATSPINIDDRVR-VEEKDVQNPHADIFQKAQQQIFKLMKFDSYTRFVRSQLYQSCMLANVEGRP 188

  Fly   952 LPYSGLDLDELLKTNFHLGAFSKLKKSASNAE----DRRRKSLLPWHRKTRSKSRDRTEIMADMQ 1012
            ||        ||.:.....|.||...|.|..|    ||.::.|     |.:..:.|..:::...:
Zfish   189 LP--------LLDSRGKPLALSKQTNSNSPREQAKFDRTKERL-----KAKPSAADAEDVVERRK 240

  Fly  1013 HALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSS-RSSLSSFDAGTATGGQ------GASTESV 1070
                             .:|:.:.|::...:...| ..|..||..|.....:      .::...|
Zfish   241 -----------------VNLQGMMGKDKRKEKRGSWGESPISFKTGLVKSSEVEKLVSRSADGKV 288

  Fly  1071 YSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIV--FQGSTKS-IDVQQPSQIL 1132
            ...|.|.|.||..::...|||.||..::..|.|||.|  |..||:  .||..|. :.:.|.|.:|
Zfish   289 DKYCCVFLPDGTASLTPARPGLTVRNMLTGLCEKRRL--PLSDIIIYLQGKDKQPLSLDQDSSVL 351

  Fly  1133 AGKEVVIERRVAFKLDLP-DPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDL 1196
            ..::|.:|.||.|.:.:. ..|.::|..|..|.|.|.:..:|:||..:..:..|.|||:...|.|
Zfish   352 QDQQVTLELRVTFAVKVAFTGKTVAVVVKSNKTLQEALAAMLNKYRLRSHEATVTMRDSGQKISL 416

  Fly  1197 NQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAA 1261
            |.|||.                                         |.||..  :|....|.|:
Zfish   417 NTPVTF-----------------------------------------LANKAL--ILDKGVDEAS 438

  Fly  1262 SEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQA 1326
            |.|                                ||.            :..|.|....|....
Zfish   439 SSK--------------------------------GNF------------SPPSFQDRRGAVDAN 459

  Fly  1327 VADP--KKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRG--TEINFDLPDFLK 1386
            :..|  .:|.:.:...|:      |.....:.|:|.|.|||....:||||  .:.:..||.||:
Zfish   460 MFSPGMSRPNVRQRNPGL------RRTYDMEGLVELLNRAQCCSADDQRGLLKKEHLMLPQFLQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	52/114 (46%)
		RGS12_RBD	1073..1145	CDD:176412	28/74 (38%)
		RBD	1144..1213	CDD:128731	20/69 (29%)
rgs14b	XP_017208541.1	RGS_R12-like	64..178	CDD:188661	52/114 (46%)
		UBQ	291..364	CDD:320785	28/74 (38%)
		TGS	365..432	CDD:330245	23/109 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6078
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144440at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24643
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920