DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF2 and MEF2

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_012433.1	Gene:	MEF2 / 853342	SGDID:	S000003638	Length:	819	Species:	Saccharomyces cerevisiae

Alignment Length:	833	Identity:	256/833 - (30%)
Similarity:	397/833 - (47%)	Gaps:	192/833 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RSYSSKIRNIGILAHIDAGKTTTTERMLFYAGKTRALGEVHRGNTVTDYLTQERERGITICSSAV 91
            ||..||:|||||:|||||||||||||||:|||.::.:|:|..|:|:||:|.|||.|||||.|:|:
Yeast    35 RSPLSKVRNIGIIAHIDAGKTTTTERMLYYAGISKHIGDVDTGDTITDFLEQERSRGITIQSAAI 99

  Fly    92 TFSW-NDHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVWSQADKHKLPRLI 155
            :|.| |...|||:|||||||||.||.::|..:|..||:||..|||||||..||.|: |.| |::.
Yeast   100 SFPWRNTFAINLIDTPGHIDFTFEVIRALKVIDSCVVILDAVAGVEAQTEKVWKQS-KSK-PKIC 162

  Fly   156 FVNKMDRPDADFEKCVSDLKDKL----ETQPVCL------QYPVKNEDGVLAINDVITLERLSWQ 210
            |:|||||..|.|...|:||.:|.    .|:||.:      :.|..|:.....:.||:..:||:|.
Yeast   163 FINKMDRMGASFNHTVNDLINKFMRGTTTKPVLVNIPYYRKQPTSNDYVFQGVIDVVNGKRLTWN 227

  Fly   211 QKDLGRSYRNVKLEPSDDLRLLQ--EKRNELIDQLSGLDDELADVVI--STESFDNVDNALIERA 271
            .::..    .:.::..|...|.|  ..|..:|:.|:..|::|....:  :...:..|....:..:
Yeast   228 PENPD----EIIVDELDGTSLEQCNRCRESMIETLTEYDEDLVQHFLEEAEGDYSKVSAQFLNAS 288

  Fly   272 LRRATTQQKVVPVLLGSAYKNVGIQRLMDAVNAYLPAPEERN----------QIYD--------- 317
            :|:.|.:..:||||.|:::||:|:|.|:||:..|||:|.|..          ..||
Yeast   289 IRKLTMKNMIVPVLCGASFKNIGVQPLLDAIVNYLPSPIEAELPELNDKTVPMKYDPKVGCLVNN 353

  Fly   318 ----CFGTEVAGKVFKIVHDKQRGPLTLVRILRGEIKRGMRLI-SARGQAEVVSKLYEPLADEYR 377
                |...     .||::.|..||....:||..|.:..|..:. |..|:...:.||..|.|...:
Yeast   354 NKNLCIAL-----AFKVITDPIRGKQIFIRIYSGTLNSGNTVYNSTTGEKFKLGKLLIPHAGTSQ 413

  Fly   378 EVSAVQSGDVVICAGLKSTV-----TGDLL---TSSQSALKNAQKRYKQSLGNTAAKVEEDDELD 434
            .|:.:.:|.:.:..|  |||     |||.|   :|.:..||:..|:.:.:|
Yeast   414 PVNILTAGQIGLLTG--STVENNISTGDTLITHSSKKDGLKSLDKKKELTL-------------- 462

  Fly   435 ESDELFAIDPQIPDAVYFCSIEPPSVSSQTAMEQALKQLQREDPSLRVSYDSVTGQTVLGGMGEL 499
            :.:.:|     ||..|:..||||.::|::.:||:||..|..|||||.:|.:..||||||.|||||
Yeast   463 KINSIF-----IPPPVFGVSIEPRTLSNKKSMEEALNTLITEDPSLSISQNDETGQTVLNGMGEL 522

  Fly   500 HMDIIKSRILSEYKIDVDLGPLQIAYKETIEAPALTTLSVEKEIAGSKQSVSITLEVVKNQAELF 564
            |::|.|.|::::.|.||:.|.|.::|||||.:.  |.:...:...|.:.|:|:.
Yeast   523 HLEIAKDRLVNDLKADVEFGQLMVSYKETINSE--TNIETYESDDGYRFSLSLL----------- 574

  Fly   565 SLDKSPDNLPNL---------NTL-----------------RPRILQVLRKGSISALERGPRVGG 603
               .:.|.|||.         |.|                 ...||..:....|..|:||.::..
Yeast   575 ---PNSDALPNCLAYPLGVNENFLIMEKNGNWDKEWKYQVSFESILNSIIASCIVGLQRGGKIAN 636

  Fly   604 -QVVETQIRLHNATIGRGTADSFVMATAAQCVQKLLSTSGT--------------RLLEPIMALQ 653
             .:....|::::         .:.:....:..|::|..:..              .||||||.|.
Yeast   637 FPLYACSIKINS---------DWSVPPDIETPQEILKITRNLIFKALNDLKPEKYNLLEPIMNLD 692

  Fly   654 IVAPSERISGIMADLS-RRRALINDV------------------------LP----------KGE 683
            :..|...:..::.||: .|:|.|..:                        :|          |.:
Yeast   693 LTIPQSDVGTVLQDLTGARKAQILSIEDESSVSNSGASTCNSPENSNRIYIPSDAVTTLHATKDK 757

  Fly   684 RN---------KMILVNAPLAELSGYSSALRTISSGTASMTMQPCGFSSMNSV 727
            :|         |:|....||.|::.|::.||::|.|.....::   :|.|..|
Yeast   758 KNTQETSSNVKKIIKAKVPLREITTYTNKLRSLSQGRGEFNIE---YSDMEKV 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	254/829 (31%)
MEF2	NP_012433.1	FusA	37..817	CDD:223556	254/831 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341682
Domainoid	1	1.000	219	1.000	Domainoid score	I464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6238
Inparanoid	1	1.050	317	1.000	Inparanoid score	I461
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53906
OrthoFinder	1	1.000	-	-		FOG0005123
OrthoInspector	1	1.000	-	-		oto100349
orthoMCL	1	0.900	-	-		OOG6_103657
Panther	1	1.100	-	-	LDO	PTHR43261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1212
SonicParanoid	1	1.000	-	-		X4147
TreeFam	1	0.960	-	-
	14	13.890