DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF2 and GFM2

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001268231.1	Gene:	GFM2 / 84340	HGNCID:	29682	Length:	811	Species:	Homo sapiens

Alignment Length:	734	Identity:	308/734 - (41%)
Similarity:	465/734 - (63%)	Gaps:	48/734 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SKIRNIGILAHIDAGKTTTTERMLFYAGKTRALGEVHRGNTVTDYLTQERERGITICSSAVTFSW 95
            :|||||||:|||||||||||||:|:|:|.||:||:|..|:||||::.|||||||||.|:||||.|
Human   100 AKIRNIGIMAHIDAGKTTTTERILYYSGYTRSLGDVDDGDTVTDFMAQERERGITIQSAAVTFDW 164

  Fly    96 NDHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVWSQADKHKLPRLIFVNKM 160
            ..:|:||:|||||:|||:|||:.|..:||.|.|.|.:|||||||:|||.|||||.:||:.|:|||
Human   165 KGYRVNLIDTPGHVDFTLEVERCLRVLDGAVAVFDASAGVEAQTLTVWRQADKHNIPRICFLNKM 229

  Fly   161 DRPDADFEKCVSDLKDKLETQPVCLQYPVKNEDGVLAINDVITLERLSWQ-QKDLGRSYRNVKLE 224
            |:..|.|:..|..:::||:.:|:.||.|:........:.||:..|:|.|. ..:.|:.:....|.
Human   230 DKTGASFKYAVESIREKLKAKPLLLQLPIGEAKTFKGVVDVVMKEKLLWNCNSNDGKDFERKPLL 294

  Fly   225 PSDDLRLLQ---EKRNELIDQLSGLDDELADVVIS--TESFDNVDNALIERALRRATTQQKVVPV 284
            ..:|..||:   |.||.||:|::.||||.||:|:.  :|:||.:....::.|:.|.|..|..|||
Human   295 EMNDPELLKETTEARNALIEQVADLDDEFADLVLEEFSENFDLLPAEKLQTAIHRVTLAQTAVPV 359

  Fly   285 LLGSAYKNVGIQRLMDAVNAYLPAPEERN-QIYDCFGTEVAGKVFKIVHDKQRGPLTLVRILRGE 348
            |.|||.||.|||.|:|||..|||:||||| :....:..::....||::||||||||..:||..|.
Human   360 LCGSALKNKGIQPLLDAVTMYLPSPEERNYEFLQWYKDDLCALAFKVLHDKQRGPLVFMRIYSGT 424

  Fly   349 IKRGMRLISARGQ-AEVVSKLYEPLADEYREVSAVQSGDVVICAGLKSTVTGDLLTSSQS----- 407
            ||..:.:.:..|. .|.:|:|..|.||::.|:.::.:|::.:..|||.|.|||.:.||:|
Human   425 IKPQLAIHNINGNCTERISRLLLPFADQHVEIPSLTAGNIALTVGLKHTATGDTIVSSKSSALAA 489

  Fly   408 ---ALKNAQKRYKQSLGNTAAKVEEDDELDESDELFAIDPQIPDAVYFCSIEPPSVSSQTAMEQA 469
               |.:..:|:::|:              :|::.|.....:||:.|:||:|||||:|.|..:|.|
Human   490 ARRAEREGEKKHRQN--------------NEAERLLLAGVEIPEPVFFCTIEPPSLSKQPDLEHA 540

  Fly   470 LKQLQREDPSLRVSYDSVTGQTVLGGMGELHMDIIKSRILSEYKIDVDLGPLQIAYKETIEAPAL 534
            ||.||||||||:|..|..:|||||.||||||::||..||..||.::..|||||:||:|||.....
Human   541 LKCLQREDPSLKVRLDPDSGQTVLCGMGELHIEIIHDRIKREYGLETYLGPLQVAYRETILNSVR 605

  Fly   535 TTLSVEKEIAGSKQSVSITLEVVKNQAELFSLDKSPDNLPNL-----NTLRPRILQV----LRKG 590
            .|.::::.: |.|:.: :|:||.....|..|:      :|.:     .::...:|:|    :..|
Human   606 ATDTLDRTL-GDKRHL-VTVEVEARPIETSSV------MPVIEFEYAESINEGLLKVSQEAIENG 662

  Fly   591 SISALERGPRVGGQVVETQIRLHNATIGRGTADSFVMATAAQCVQKLLSTSGTRLLEPIMALQIV 655
            ..||..:||.:|..:.:..|.||:.||..||:.:.:.|..::||||.|..:..::|||:|.|::.
Human   663 IHSACLQGPLLGSPIQDVAITLHSLTIHPGTSTTMISACVSRCVQKALKKADKQVLEPLMNLEVT 727

  Fly   656 APSERISGIMADLSRRRALINDVLPKGERNKMILVNAPLAELSGYSSALRTISSGTASMTMQPCG 720
            ...:.:|.::|||::||..|.::..: :.||:::...||||:.|||:.|||::||:|:..::...
Human   728 VARDYLSPVLADLAQRRGNIQEIQTR-QDNKVVIGFVPLAEIMGYSTVLRTLTSGSATFALELST 791

  Fly   721 FSSMNSVDESLAERRAQGL 739
            :.:||..|::....|..||
Human   792 YQAMNPQDQNTLLNRRSGL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	305/726 (42%)
GFM2	NP_001268231.1	PRK12739	98..809	CDD:237185	306/731 (42%)
		EF-G	104..384	CDD:206673	145/279 (52%)
		mtEFG2_II_like	399..480	CDD:293909	31/80 (39%)
		EFG_III	518..593	CDD:293919	45/74 (61%)
		mtEFG2_like_IV	594..714	CDD:238842	35/127 (28%)
		EFG_mtEFG_C	719..795	CDD:239683	26/76 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141953
Domainoid	1	1.000	291	1.000	Domainoid score	I1545
eggNOG	1	0.900	-	-		E1_COG4108
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6238
Inparanoid	1	1.050	558	1.000	Inparanoid score	I1104
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53906
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	1	1.000	-	-		FOG0005123
OrthoInspector	1	1.000	-	-		oto91741
orthoMCL	1	0.900	-	-		OOG6_103657
Panther	1	1.100	-	-	LDO	PTHR43261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1212
SonicParanoid	1	1.000	-	-		X4147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800