DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mRRF2 and gfm2

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001071013.1	Gene:	gfm2 / 558184	ZFINID:	ZDB-GENE-060201-3	Length:	762	Species:	Danio rerio

Alignment Length:	759	Identity:	325/759 - (42%)
Similarity:	474/759 - (62%)	Gaps:	51/759 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QSNRWLWHLSNQIWKRSYS-----------------SKIRNIGILAHIDAGKTTTTERMLFYAGK 59
            |:.||     ...||||||                 ||||||||:|||||||||||||||:|:|.
Zfish    23 QAPRW-----RVTWKRSYSLLQDEVKSLRTVVNPDISKIRNIGIMAHIDAGKTTTTERMLYYSGY 82

  Fly    60 TRALGEVHRGNTVTDYLTQERERGITICSSAVTFSWNDHRINLLDTPGHIDFTMEVEQSLYAVDG 124
            |||||:|..|:|||||:.|||||||||.|:||||.|.|:||||:|||||:|||:|||::|..:||
Zfish    83 TRALGDVDDGDTVTDYMAQERERGITIQSAAVTFDWKDYRINLIDTPGHVDFTLEVERALRVLDG 147

  Fly   125 VVVVLDGTAGVEAQTVTVWSQADKHKLPRLIFVNKMDRPDADFEKCVSDLKDKLETQPVCLQYPV 189
            .|.|.|.:|||||||:|||.||:||::|.:.|:||||:|.|.....:..:|.||:..||.||.|:
Zfish   148 AVAVFDASAGVEAQTMTVWRQAEKHQIPCVCFLNKMDKPAASLRYSLDSIKAKLKANPVLLQIPI 212

  Fly   190 KNEDGVLAINDVITLERLSWQQKDL---GRSYRNVKLEPSDD---LRLLQEKRNELIDQLSGLDD 248
            .:......:.|:||.:::.||...|   |||:....|:||||   |..:.|.|..||:|::.|||
Zfish   213 GSGKSFTGLVDLITRQKMMWQGNALTNDGRSFEINSLQPSDDPNVLLAVSEARAALIEQVADLDD 277

  Fly   249 ELADVVIST--ESFDNVDNALIERALRRATTQQKVVPVLLGSAYKNVGIQRLMDAVNAYLPAPEE 311
            |.|::::..  |:||.|....::.|:||.|..:|.||||.||:.||.|:|.|:||:.||||||.|
Zfish   278 EFAELLLGEYGENFDAVPAVKLQEAVRRVTLARKGVPVLCGSSLKNKGVQPLLDAITAYLPAPNE 342

  Fly   312 RN-QIYDCFGTEVAGKVFKIVHDKQRGPLTLVRILRGEIKRGMRLISA-RGQAEVVSKLYEPLAD 374
            || .:...:..::....||:|||||||||..|||..|.:|....:.:. |.:.|.:|:|..|.||
Zfish   343 RNHDLVRWYKNDLCALAFKVVHDKQRGPLVFVRIYSGSMKAQSSVHNINRNETEKMSRLLLPFAD 407

  Fly   375 EYREVSAVQSGDVVICAGLKSTVTGDLLTSSQSALKNAQKRYKQSLGNTAAKVEEDDELDESDEL 439
            :..|:.::.:|::.:..|||.|||||.:.||:::...|.:|.:          .|.:.:..|...
Zfish   408 QQIEIPSLSAGNIALTVGLKQTVTGDTIVSSKASAAAAIRRAQ----------AEAESMSNSHSA 462

  Fly   440 FAIDPQIPDAVYFCSIEPPSVSSQTAMEQALKQLQREDPSLRVSYDSVTGQTVLGGMGELHMDII 504
            .....::|:.|:|||||||:::.|..:|.||..||||||||:|..|..:|||||.||||||::||
Zfish   463 ALAGVEVPEPVFFCSIEPPTMAKQADLEHALNCLQREDPSLKVRIDPDSGQTVLCGMGELHIEII 527

  Fly   505 KSRILSEYKIDVDLGPLQIAYKETIEAPALTTLSVEKEIAGSKQ---SVSITLEVVKNQAELFSL 566
            ..||..||||:..|||||:||:||| ..::|...:...|.|.|:   ||.:|:..:|..:.. |.
Zfish   528 HDRIKREYKIETHLGPLQVAYRETI-LQSVTAKDLLDRILGEKRHVVSVELTVHPLKENSSA-SC 590

  Fly   567 DKSPDNLPNLNTLRPR-ILQVLRKGSISALERGPRVGGQVVETQIRLHNATIGRGTADSFVMATA 630
            |.:.:.  ::..:.|. :.:.:..|..||..:||.:|..|...|..:.:..:..||:.:.|.|..
Zfish   591 DITFEE--DVKAMLPADVREAVENGVQSAYLQGPVLGFPVQGVQTVIQDVRLESGTSAAMVSACV 653

  Fly   631 AQCVQKLLSTSGTRLLEPIMALQIVAPSERISGIMADLSRRRALINDVLPKGERNKMILVNAPLA 695
            ::|:.|.|..:|.::|||:|||::....|.:|.::||||:||..|.|:..: :.||::|.:.|||
Zfish   654 SRCMLKALKQAGGQVLEPVMALEVTVGEEHLSSVLADLSQRRGTICDIQSR-QDNKILLADVPLA 717

  Fly   696 ELSGYSSALRTISSGTASMTMQPCGFSSMNSVDESLAERRAQGL 739
            |:.|||:.|||::||.|:.:::...:..|||.|:::...:..||
Zfish   718 EMMGYSTVLRTLTSGNATFSLELSSYEPMNSQDQNILLNKMAGL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	314/715 (44%)
gfm2	NP_001071013.1	PRK12739	52..760	CDD:237185	314/722 (43%)
		EF-G	58..340	CDD:206673	151/281 (54%)
		mtEFG2_II_like	355..437	CDD:293909	33/81 (41%)
		EFG_III	470..545	CDD:293919	45/74 (61%)
		mtEFG2_like_IV	546..665	CDD:238842	31/122 (25%)
		EFG_mtEFG_C	670..746	CDD:239683	31/76 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574861
Domainoid	1	1.000	301	1.000	Domainoid score	I1389
eggNOG	1	0.900	-	-		E1_COG4108
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6238
Inparanoid	1	1.050	575	1.000	Inparanoid score	I1010
OMA	1	1.010	-	-		QHG53906
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	1	1.000	-	-		FOG0005123
OrthoInspector	1	1.000	-	-		oto40316
orthoMCL	1	0.900	-	-		OOG6_103657
Panther	1	1.100	-	-	LDO	PTHR43261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1212
SonicParanoid	1	1.000	-	-		X4147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800