DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mRRF2 and waw

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	161/762 - (21%)
Similarity:	271/762 - (35%)	Gaps:	282/762 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GPKQSNRWLWHLSNQIWKRSYSS--------------------------KIRNIGILAHIDAGKT 47
            |.|:.:.||...|..:..|:.|:                          :|||..|:||:|.||:
  Fly    49 GDKRHSAWLVARSKSLLVRNLSTTNQVKGETEEPSQADLLREFAHMPVERIRNFSIIAHVDHGKS 113

  Fly    48 TTTERMLFYAGKTRALGEVHRGNTVTDYLTQERERGITICSSAVTFSWNDHR-----INLLDTPG 107
            |..:|:|...|.....|..|:   |.|.|..|||||||:.:...:. ::.|:     :||:||||
  Fly   114 TLADRLLELTGAIARNGGQHQ---VLDNLQVERERGITVKAQTASI-FHRHKGQLYLLNLIDTPG 174

  Fly   108 HIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVWSQADKHKLPRLIFVNKMDRPDADFEKCVS 172
            |:||:.||.:||.|.||||:::|...||:||||..:..|.:.:|..:..:||:|...|:.::...
  Fly   175 HVDFSNEVSRSLAACDGVVLLVDACHGVQAQTVANYHLAKQRQLAVVPVLNKIDIKHANPDQVCQ 239

  Fly   173 DLKDKLETQPVCLQYPVKNEDGVLAINDVITLERLSWQQKDLGRSYRNVKLEPSDDLRLLQEKRN 237
            |||
  Fly   240 DLK-------------------------------------------------------------- 242

  Fly   238 ELIDQLSGLD-DELADVVISTESFDNVDNALIERALRRATTQQKVVPVLLGSAYKNVGIQRLMDA 301
                .|.|:| ||                                  ||..||....|:..:::.
  Fly   243 ----LLFGIDPDE----------------------------------VLRVSAKLGTGVSEVLER 269

  Fly   302 VNAYLPAPEERNQIYDCFGTEVAGKVFKIVHDKQRGPLTLVRILRGEIKRGMRLISARGQAEVVS 366
            |...:|.|:.:..      ::....:|....||.||.|.|:.:|.|::::...:     |:....
  Fly   270 VIETVPPPQVQRD------SDFRALIFDSWFDKYRGALNLIYVLNGKLEQNQDI-----QSLATK 323

  Fly   367 KLY--------EPLADEYREVSAVQSGDVVIC--AGLKSTVTGDLLTSSQSALKNAQKRYKQSLG 421
            |:|        .|......:|||.|.| ::.|  ...|.::.||.:.....|:. |...|:
  Fly   324 KVYSVKSISVLRPAECPVPDVSAGQVG-LIACNMRNSKESIVGDTIHLKNQAVA-AAGSYR---- 382

  Fly   422 NTAAKVEEDDELDESDELFAIDPQIPDAVYFCSIEPPSVSSQTAMEQALKQLQREDPSLRVSYDS 486
                                  ||.|  :.|..:.|...|...|:..|:.::...|.::.|..||
  Fly   383 ----------------------PQQP--LVFAGVFPADQSKHVALRSAIDKMVLNDSAVTVKIDS 423

  Fly   487 --VTGQ-TVLGGMGELHMDIIKSRILSEYKIDVDLGPLQIAYKETIEAPALT---TLSVEKEIAG 545
              ..|| ..||.:|.|||::...|:..|:..:    |:       |.||::|   .||..|.|
  Fly   424 SPALGQGWRLGFLGLLHMEVFCQRLEQEHGAE----PI-------ITAPSVTYRLVLSNPKMI-- 475

  Fly   546 SKQSVSITLEVVKNQAELFSLDKSPDNLPNLNTLRPRILQVLRKGSISALERGPRVGGQVVETQI 610
             ||....|:::  :.|.||         |..::::
  Fly   476 -KQQGRDTMDI--SNAALF---------PEPHSIK------------------------------ 498

  Fly   611 RLHNATIGRGTADSFVMATAAQCVQKLLSTSGTRLLEPIMALQIVAPSERISGIMADLSRRRALI 675
                                             ...||::...|:.|:|.:..:::....||.|.
  Fly   499 ---------------------------------EYYEPLVLGTIITPTEYVGQVISLCVERRGLQ 530

  Fly   676 NDVLPKGERNKMILVNAPLAE-LSGYSSALRTISSGTASMTMQPCGF 721
            ...:...:...::....||:| :..:...|:::|||.||.:.:..|:
  Fly   531 QSSVNIDDTRVLMKYVLPLSEIILDFHDRLKSLSSGYASFSYEDHGY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	154/740 (21%)
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	154/717 (21%)
		LepA	100..277	CDD:206677	71/280 (25%)
		EF4_II	285..370	CDD:293900	22/90 (24%)
		EF4_III	386..461	CDD:293917	22/87 (25%)
		lepA_C	502..581	CDD:239680	18/76 (24%)
		LepA_C	589..695	CDD:283959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840