DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF2 and eRF3

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	87/459 - (18%)
Similarity:	155/459 - (33%)	Gaps:	160/459 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QSGPKQSNRWLWHLSNQIWKRSYSSKIRNIGILAHIDAGKTTTTERMLFYAGKT--RALGEVHRG 69
            ::.||.|.:.:..:.....||.:.    |:..:.|:||||:|...:::...|..  |.|.:..|.
  Fly   173 EATPKVSKKKVVKVEENRSKREHV----NVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYERE 233

  Fly    70 -----------NTVTDYLTQERERGITICSSAVTFSWNDHRINLLDTPGHIDFTMEVEQSLYAVD 123
                       :...|...:||::|.|:......|..:.....:||.|||..|...:.......|
  Fly   234 AREKSRESWYLSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQAD 298

  Fly   124 GVVVVLDGTAG----------------VEAQTVTVWSQADKHKLPRLIFVNKMDRPDADFEKC-V 171
            ..|:|:....|                :.|:|..|     ||   .::.|||||.|..::::. .
  Fly   299 LAVLVISARKGEFETGFDRGGQTREHAMLAKTAGV-----KH---LVVLVNKMDDPTVNWDQTRY 355

  Fly   172 SDLKDKLETQPVCLQYPVKNEDGVLAINDVITLERLSWQQKDLGRSYRNVKLEPSDDLRLLQEKR 236
            ::.|||:      |.|                       .|.||       ..|:.||..:.
  Fly   356 NECKDKI------LPY-----------------------LKKLG-------FNPAKDLTFMP--- 381

  Fly   237 NELIDQLS--GLDDELADVVI----STESFDNVDNALIERALRRATTQQKVVPVLLGSAYKNVGI 295
               ...||  ||.|::.:.:.    .......:|..   .:|.|.:....::|::  ..||::
  Fly   382 ---CSGLSGYGLKDQIPETLCPWYRGPAFIPFIDEL---PSLNRKSDGPFIMPIV--DKYKDM-- 436

  Fly   296 QRLMDAVNAYLPAPEERNQIYDCFGTEVAGKVFKIVHDKQRGPLTLVRILRGEIKRGMRLISARG 360
                                    ||.|.|||..                 |..::|..|:....
  Fly   437 ------------------------GTVVMGKVES-----------------GTARKGQNLLVMPN 460

  Fly   361 QAEV-VSKLYEPLADEYREVSAVQSGD-----------------VVICAGLKSTVTGDLLTSSQS 407
            :.:| |.:|:   :|:: ||::|..|:                 .|:|.......||.:..:...
  Fly   461 RTQVAVDQLF---SDDF-EVTSVGPGENVKIKLKGIEEEDVSPGFVLCDAANPIKTGKIFDAQVV 521

  Fly   408 ALKN 411
            .|::
  Fly   522 ILEH 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	82/435 (19%)
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	84/441 (19%)
		EF1_alpha	197..416	CDD:206670	55/271 (20%)
		eRF3_II	424..505	CDD:293906	21/129 (16%)
		eRF3_C_III	511..617	CDD:294003	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930