DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mRRF2 and mEFG1

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	224/780 - (28%)
Similarity:	374/780 - (47%)	Gaps:	134/780 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KRSYSS-----------KIRNIGILAHIDAGKTTTTERMLFYAGKTRALGEVHRGNTV---TDYL 76
            |..|||           :||||||.||||:||||.|||:|||.|:...:.||...:.|   .|.:
  Fly    24 KAGYSSHAKFSEHKPIERIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSM 88

  Fly    77 TQERERGITICSSAVTFSWNDHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVT 141
            ..||:|||||.|:|....|.|..||::|||||:|||:|||::|..:||.|:||....||::||:|
  Fly    89 ELERQRGITIQSAATYTLWKDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLT 153

  Fly   142 VWSQADKHKLPRLIFVNKMDRPDADFEKCVSDLKDKLETQPVCLQYPVKNEDGVLAINDVITLER 206
            |..|..::.:|.|.|:||:||..::..:.:|.::.|:......:|.|:..|.....|.|::..:.
  Fly   154 VNRQMKRYNVPCLAFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKA 218

  Fly   207 LSWQQKDLGRSYRNVKL-EPSDDLRLLQ-EKRNELIDQLSGLDDELADVVISTESFDNVDNALIE 269
            :.::    |....:::| |...|:|:.. |:|.|||:.||..|:.|.::.:..:.|...|   |:
  Fly   219 IYFE----GEHGMDIRLDEIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDD---IK 276

  Fly   270 RALRRATTQQKVVPVLLGSAYKNVGIQRLMDAVNAYLPAPEERNQIYDCFGTEVAGKVFKIVHDK 334
            .||||....:...|||:|:|.||.|:|.|:|||..|||.|.|         .|..|.:.|...|.
  Fly   277 AALRRTCINRTFTPVLVGTALKNKGVQPLLDAVLDYLPNPGE---------VENLGFIEKEGQDP 332

  Fly   335 QR-------------------------GPLTLVRILRGEIKRGMRLISARGQAEV-VSKLYEPLA 373
            ::                         |.||.:|..:|.:::|..:.:||...:| :::|....:
  Fly   333 EKVVLNPARDGKDPFVGLAFKLEAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRIARLVRLHS 397

  Fly   374 DEYREVSAVQSGDVVICAGLKSTVTGDLLTSSQSALKNAQKRYKQSLGNTAAKVEEDDELDESDE 438
            ::..:|:.|.:||:....|: ...:||..|::.          |.:|              ..:.
  Fly   398 NQMEDVNEVYAGDIFALFGV-DCASGDTFTTNP----------KNNL--------------SMES 437

  Fly   439 LFAIDPQIPDAVYFCSIEPPSVSSQTAMEQALKQLQREDPSLRVSYDSVTGQTVLGGMGELHMDI 503
            :|     :|:.|...:|:|.:...:....:|:.:..:|||:....:|:...:|::.||||||::|
  Fly   438 IF-----VPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGELHLEI 497

  Fly   504 IKSRILSEYKIDVDLGPLQIAYKETIEAPALTTLSVEKEIAGSKQSVSITLEVVKNQAELFSLDK 568
            ...|:..||...|.||..::|::||:..|.......:|:..||.|...|          :..::.
  Fly   498 YAQRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGSGQYARI----------IGVMEP 552

  Fly   569 SPDNLPNLNTL------------RPRILQVLRKGSISALERGPRVGGQVVETQIRLHNATIGRGT 621
            .|   ||.|||            ..:.:..:.||.....|:|...|.::...:.||.:.  |...
  Fly   553 LP---PNQNTLLEFVDETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRFRLQDG--GHHI 612

  Fly   622 ADS----FVMATAAQCVQKLLSTSGTRLLEPIMALQIVAPSERISGIMADLSRRRALINDVLPKG 682
            .||    |::| |...::::......::|||||.:::.||.|....:|..||:|..:|...  :|
  Fly   613 VDSSELAFMLA-AHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGT--EG 674

  Fly   683 ERNKM-ILVNAPLAELSGYSSALRTISSGTASMTMQ-----PCGFSSMNSVDESLAE--RRAQGL 739
            ..... :....||.::.||:..||:.:.|....||:     ||    :..|.:.:..  :.:|||
  Fly   675 TEGWFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPC----LPDVQDQIVRQYQESQGL 735

Fly 740 739
Fly 736 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	218/765 (28%)
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	111/278 (40%)
		PRK12740	48..727	CDD:237186	211/746 (28%)
		mtEFG1_II_like	347..427	CDD:293908	17/80 (21%)
		EFG_III	441..516	CDD:293919	23/74 (31%)
		EFG_mtEFG1_IV	519..636	CDD:238715	27/132 (20%)
		mtEFG1_C	641..718	CDD:239764	24/82 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850