DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF2 and Y119D3B.14

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_497345.2	Gene:	Y119D3B.14 / 191043	WormBaseID:	WBGene00022491	Length:	731	Species:	Caenorhabditis elegans

Alignment Length:	740	Identity:	267/740 - (36%)
Similarity:	415/740 - (56%)	Gaps:	46/740 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KRSYS--------SKIRNIGILAHIDAGKTTTTERMLFYAGKTRALGEVHRGNTVTDYLTQERER 82
            :|.||        ||:||||::||:||||||.|||:|:.||.....|.|.:||||||:|..||||
Worm    10 RRCYSTPPPPPAPSKLRNIGVIAHVDAGKTTVTERLLYLAGAIHVAGHVDKGNTVTDFLDIERER 74

  Fly    83 GITICSSAVTFSWNDHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVWSQAD 147
            |||:.|:||...|..|||||:|||||:||.:|||:.:..:||:|||:||:|||:.||:|||.|:.
Worm    75 GITVQSAAVNLDWKGHRINLIDTPGHVDFRVEVERCVRVLDGIVVVIDGSAGVQPQTLTVWRQSS 139

  Fly   148 KHKLPRLIFVNKMDRPDADFEKCVSDLKDKLETQPVCLQYPVKNEDGV-LAINDVITLERLSWQQ 211
            |.|||...|:||||:..|:||..|..::.||..:.|.|..|:....|. ....|::..:.|....
Worm   140 KFKLPAHFFINKMDKLAANFENSVDSVEQKLGVRAVKLVVPLPENRGFNRGFLDILHSKMLPGNS 204

  Fly   212 KDLGRSYRNVKLEPSDDLRLLQEKRNELIDQLSGLDDELADVVIS-TESFD----NVDNALIERA 271
            |:.....:|     |.:..||.|.::||...|:   |..||.... .:.||    .:|...::..
Worm   205 KNWQNPPKN-----SPEAELLAEHKSELCFTLA---DSHADFQSKFLDEFDGNSEKIDVIEMKSV 261

  Fly   272 LRRATTQQKVVPVLLGSAYKNVG-IQRLMDAVNAYLPAPEERNQIY-DCFGTEVAGKVFKIVHDK 334
            ||..|...|:..:..|||.|||. ::.::|||..:.||||.||:.: |.||.:::|.||||.|||
Worm   262 LRELTCASKIATISCGSAVKNVHCVKPVLDAVVDFFPAPEMRNREFRDVFGEDLSGLVFKITHDK 326

  Fly   335 QRGPLTLVRILRGEIKRGMRLI-SARGQAEVVSKLYEPLADEYREVSAVQSGDVVICAGLKSTVT 398
            :||.|:.:||..|.:.....:. :::..:|...||:.|.|||.|.|..|.:|::.:.|||::|||
Worm   327 RRGQLSYMRIYTGSLHNNSTIFNTSQMTSEGPLKLFTPYADELRLVEQVSAGNITVVAGLQTTVT 391

  Fly   399 GDLLTSSQSALKNAQKRYKQSLGNTAAKVEEDDELDESDELFAIDPQIPDAVYFCSIEPPSVSSQ 463
            ||.:.:|.:   :|:|..::..|:.::.:...|    .:.:.....:.||||:||.|||||....
Worm   392 GDTVVASSA---SAEKACQKLAGSESSLLSPKD----GNSVVFSGIESPDAVFFCCIEPPSNRQL 449

  Fly   464 TAMEQALKQLQREDPSLRVSYDSVTGQTVLGGMGELHMDIIKSRILSEYKIDVDLGPLQIAYKET 528
            ....:||::|.|||||:::.:|..||||::...||||::.||.|:...||:||.:|.||:||:|.
Worm   450 NQFNKALEELTREDPSMKIRFDRDTGQTIVETQGELHLEAIKDRLKRNYKLDVFIGKLQVAYREM 514

  Fly   529 IEAPALTTLSVEKEIAGSK--QSVSITLEVVKNQAELFSLDKSPDNLPNLNTLRPRIL---QVLR 588
            :......|..||..::..|  :.|.:|:.:...||.: ...|....||  .|.||..|   :.:.
Worm   515 LTEELSYTAKVEDGLSEKKRPEFVQLTMRLEPTQAHI-PFKKIELELP--QTARPVRLDWQKAVN 576

  Fly   589 KGSISALERGPRVGGQVVETQIRLHNATIGRGTADSFVMATAAQ-CVQKLLSTSGTRLLEPIMAL 652
            :|..:||:.||.....|...::.|....:..|..:..:::..|| ||.:.||:....|.||:|.:
Worm   577 EGCSNALQNGPLASYPVHAVRVVLTECIVSGGKINPALLSACAQKCVSEALSSGEMVLTEPVMEV 641

  Fly   653 QI-VAPSERISGIMADLSRRRALI--NDVLPKGERNKMILVNAPLAELSGYSSALRTISSGTASM 714
            || :...:....|:.:|.||||..  :|.....|..::..: .||:|....|..:||::||...:
Worm   642 QIEIRNDDPTQPILNELLRRRAHFEHSDATESTEIRRICAI-LPLSETENLSKTVRTLTSGFGDI 705

  Fly   715 TMQPCGFSSMNSVDE-SLAERRAQG 738
            ::|..|:..:...:: .:.::||.|
Worm   706 SVQFRGYQQVTEHEKMEILKKRATG 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	261/720 (36%)
Y119D3B.14	NP_497345.2	FusA	23..727	CDD:223556	261/722 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156688
Domainoid	1	1.000	208	1.000	Domainoid score	I1672
eggNOG	1	0.900	-	-		E1_COG4108
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6238
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1026
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53906
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	1	1.000	-	-		FOG0005123
OrthoInspector	1	1.000	-	-		oto17810
orthoMCL	1	0.900	-	-		OOG6_103657
Panther	1	1.100	-	-	LDO	PTHR43261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1212
SonicParanoid	1	1.000	-	-		X4147
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800